Prochazka, Vit; Trneny, Marek; Pytlik, Robert; Vasova, Ingrid; Kral, Zdenek; Belada, David; Kozak, Tomas; Kubackova, Katerina; Siffnerova, Hana; Matuska, Milan; Lysy, Milan; Bolomska, Inge; Petrakova, Katarina; Otavova, Barbora; Pribylova, Jana; Svecova, Jirina; Papajik, Tomas; Hamouzova, Michaela; Petrova, Marketa; Zapletalova, Jana
June 2007
Biomedical Papers of the Medical Faculty of Palacky University i;2007, Vol. 151 Issue 1, p103
Academic Journal
Background: Peripheral T-cell lymphoma, unspecified (PTCL-US) is one of the entities from the infrequent family of nodal mature T-cell lymphomas. The clinical course is aggressive, and despite multiagent chemotherapy, the median survival is about 2 years. Published data are limited to restrospective, mostly single-center studies or reviews and usually include more lymphoma subtypes. Aim: To evaluate the current treatment modalities, clinical outcome and prognostic factors in unselected, new diagnosed patients with PTCL-US in the population of the central european region (Czech Republic). Method: Czech Lymphoma Study Group is a national scientific organization which provides an on-line database registry which collects a data about almost all new diagnosed lymphoma patients since year 2000. All diagnostic biopsies were reviewed by a reference pathologist. Results: We analyzed 63 patients with new diagnosis of PTCL-US. The median age was 59 years (25-81), chemotherapy (CHT) was administered in 56 of the 63 patients: anthracyclin-based CHT in 51 %, intensive CHT in 21 % and non-anthracyclin regimen was applied in 13 % of the patients. The overall response rate was 74.4 %, (CR in 57.4 %). After a median follow-up of 19.6 months, 41 % of the patients were in CR, 3.4 % in PR or stable disease and 55 % of the patients died. The estimated survival probability in 3 years was 36 %. Clinical stage (IV) and CR achievement were found to be independent survival predictors in a multivariate analysis. Conclusions: Although the current treatment modalities are mostly ineffective in PTCL-US, appropriate intesive treatment may lead to prolonged remission but not survival.


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