TITLE

HUNTINGTON'S DISEASE AND STEROID HORMONE RECEPTORS

AUTHOR(S)
Molikova, Radka; Bezdickova, Marcela; David, Ondrej; Bebarova, Linda
PUB. DATE
June 2007
SOURCE
Biomedical Papers of the Medical Faculty of Palacky University i;2007, Vol. 151 Issue 1, p53
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Steroid hormone receptors constitute a special group of receptors having a wide range of efficiency and distribution in the body. Androgen and estrogen receptors, and their expression in the body, are linked with attributes such as reproduction control and sexual behaviour, but their relation with behavioural models, perception, memory and stress remain unclear to date. Purpose: In this project we aim to focus on monitoring the expressive influence of steroid hormone receptors on embryonic tissues and subsequently, expand our study to include the expression on adult tissues such as the CNS and to monitor the developmental aspects and relations pertaining to neurodegenerative disorders, such as Huntington's disease. Material and Methods: We shall rely on immuno-histochemistry, immuno-fluorescence and RT-PCR methods for detecting steroid hormone receptors and Huntingtin-associated protein 1 in the embryonic and adult tissue. Conclusion: Mapping the expression of steroid receptors during development represents an essential step in the quest for further studies and monitoring of the expression in adult tissues.
ACCESSION #
31371728

 

Related Articles

  • DISTRIBUTION OF NUCLEAR RECEPTORS FOR STEROID HORMONES IN THE HUMAN BRAIN: A PRELIMINARY STUDY. Bezdickova, Marcela; Molikova, Radka; Bebarova, Linda; Kolar, Zdenek // Biomedical Papers of the Medical Faculty of Palacky University i;2007, Vol. 151 Issue 1, p69 

    Background: Expression of the nuclear steroid hormone receptors (SHR) within certain parts of the human brain has been described by many authors. However, a comprehensive analysis of SHR expression in the human brain still has not been performed. Aim: To investigate the expression of SHR in...

  • Membrane Localization of Estrogen Receptors. Marino, Maria; Galluzzo, Paola // Immunology, Endocrine & Metabolic Agents - Medicinal Chemistry;Sep2009, Vol. 9 Issue 3, p170 

    17�-Estradiol (E2) is a steroid hormone that regulates the expression of a variety of genes involved in distinct physiological processes, including development, metabolism, and reproduction. The effects start when the hormone binds to the specific intracellular receptors ERa and ER�,...

  • Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors. Ito, Fabio Augusto; Ito, Kazuhiro; Coletta, Ricardo Della; Vargas, Pablo Agustín; Lopes, Márcio Ajudarte // Brazilian Oral Research;Oct-Dec2009, Vol. 23 Issue 4, p393 

    The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands. A total of 41 pleomorphic adenomas, 30...

  • Clinical Studies on Hormonal Status in Breast Cancer and its Impact on Quality of Life (QOL). Jamil, Kaiser; Kumar, Kalyan; Fatima, S. Hajira; Rabbani, Syed; Kumar, Ravi; Perimi, Ramesh // Journal of Cancer Science & Therapy;Dec2009, Vol. 1 Issue 2, p1 

    Breast cancer is a steroid hormone-dependent tumor. Stratification of patients according to hormone (ER/ PR) receptor status and nodal metastasis is of great therapeutic importance. In this investigation, we could enroll 79 pre and post-menopausal breast cancer patients voluntarily. We...

  • Androgens and Sexual Behavior. Gorski, Roger A.; Lippe, Barbara M.; Green, Richard // Annals of Internal Medicine;Apr82, Vol. 96 Issue 4, p488 

    Focuses on studies on the relationship of androgens with sexual behavior. Function of androgens; Brain uptake of steroid hormones; Effects of androgen exposure on the perinatal animal brain; Comparative aspects of sexual differentiation of the brain.

  • A Novel Universal Primer-Multiplex-PCR Method with Sequencing Gel Electrophoresis Analysis. Wentao Xu; Zhifang Zhai; Kunlun Huang; Nan Zhang; Yanfang Yuan; Ying Shang; Yunbo Luo // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    In this study, a novel universal primer-multiplex-PCR (UP-M-PCR) method adding a universal primer (UP) in the multiplex PCR reaction system was described. A universal adapter was designed in the 5'-end of each specific primer pairs which matched with the specific DNA sequences for each template...

  • Estrogen receptor-associated expression of keratinocyte growth factor and its possible role in the inhibition of apoptosis in human breast cancer. Tamaru, Naóe; Hishikawa, Yoshitaka; Ejima, Kuniaki; Nagasue, Naofumi; Inoue, Satoshi; Muramatsu, Masami; Hayashi, Tomayoshi; Koji, Takehiko // Laboratory Investigation (00236837);Nov2004, Vol. 84 Issue 11, p1460 

    Although estrogen is known to play a crucial role in the pathogenesis of breast cancer, the molecular mechanisms underlying the action of estrogen remain elusive. In the present study, we focused on keratinocyte growth factor (KGF) and its receptor (KGFR) in the pathogenesis of breast cancer, as...

  • Are estrogen receptors alpha detectable in normal and abnormal thyroid tissue? Vaiman, Michael; Olevson, Youlian; Sandbank, Judith; Habler, Liliana; Zehavi, Sergei; Kessler, Alex // European Archives of Oto-Rhino-Laryngology;Nov2010, Vol. 267 Issue 11, p1753 

    The aims of this study is to evaluate the presence of estrogen receptors alpha (ERα) in thyroid lesions and to assess the practicality of this test in view of numerous disagreements on the subject. Immunohistochemical stains were performed for ERα, for the evaluation of immunoreactivity in...

  • Estrogen Regulation of Adipose Tissue Functions: Involvement of Estrogen Receptor Isoforms. Pallottini, V.; Bulzomi, P.; Galluzo, P.; Martini, C.; Marino, M. // Infectious Disorders - Drug Targets;Mar2008, Vol. 8 Issue 1, p52 

    Adipose tissue has recently been described as one of the major endocrine gland that plays a role in energy homeostasis, lipid metabolism, immune response, and reproduction. An excess of white adipose tissue, caused by a complex interaction between genetic, hormonal, behavioral, and environmental...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics