Structural characterization of trimethylsilyl methyl glycosides derivatives by high-resolution mass spectrometry, linked scans and MIKE experiments

Loutelier-Bourhis, Corinne; Bardor, Muriel; Lange, Catherine M.
April 2008
Analytical & Bioanalytical Chemistry;Apr2008, Vol. 390 Issue 7, p1853
Academic Journal
Gas chromatography–mass spectrometry investigations have been carried out for the structural analysis of trimethylsilyl methyl derivatives of keto-deoxy sugars and sialic acids studied under electron ionization. Fragmentation patterns were determined. The three derivatives undergo some common fragmentation pathways. Formation of fragment ions possessing cyclic resonance-stabilized structures was demonstrated. As the sialic acid derivative contained a N-acetyl substituent, some additional fragmentations occurred and were also elucidated. Thus, the mechanism of fragmentation was revealed for these derivatives and new findings concerning some series of fragment ions are presented.


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