Role of obesity in GORD-related disorders

El-Serag, Hashem
March 2008
Gut;Mar2008, Vol. 57 Issue 3, p281
Academic Journal
Obesity satisfies several criteria for a causal association with GORD and its complications including generally consistent association and some dose--response relationship. Abdominal obesity seems to explain a considerable part of this association operating mostly by increasing intragastric pressure, gastroesophageal gradient, TLOSR, and oesophageal acid exposure. Additional humoral mechanisms may be important in Barrett's oesophagus and oesophageal adenocarcinoma but this remains poorly examined. Maintaining normal weight may reduce the likelihood of developing GOAD and its potential complications.


Related Articles

  • Obesity Prevention and National Food Security: A Food Systems Approach. Rutten, Lila Finney; Yaroch, Amy Lazarus; Patrick, Heather; Story, Mary // ISRN Public Health;2012, p1 

    Interventions that cultivate sustainable food systems to promote health, prevent obesity, and improve food security have the potential for many large-scale and long-lasting benefits including improvements in social, environmental, health, and economic outcomes. We briefly summarize findings from...

  • It's Never Too Early to Prevent Obesity. Sloviter, Vikki // Pediatrics for Parents;Nov/Dec2011, Vol. 27 Issue 11/12, p29 

    The article discusses a study that determines the critical period when children experience a significant body mass index (BMI) gain. The author provides an overview on the use of body mass index to determine the weight status of a child. She also emphasizes that early elementary school may be an...

  • Accuracy and usefulness of BMI measures based on self-reported weight and height: findings from the NHANES & NHIS 2001-2006. Stommel, Manfred; Schoenborn, Charlotte A. // BMC Public Health;2009, Vol. 9, p421 

    Background: The Body Mass Index (BMI) based on self-reported height and weight ("self-reported BMI") in epidemiologic studies is subject to measurement error. However, because of the ease and efficiency in gathering height and weight information through interviews, it remains important to assess...

  • Obesity Paradox should not interfere with public health efforts. Stevens, J; Bradshaw, P T; Truesdale, K P; Jensen, M D // International Journal of Obesity;Jan2015, Vol. 39 Issue 1, p80 

    The Obesity Paradox could result in confusing messages that derail beneficial environmental changes and lead to reduced efforts by physicians to provide healthy lifestyle treatment plans to their obese patients. The Obesity Paradox applies in the main to individuals who have a disease, and...

  • Designing Insurance to Promote Use of Childhood Obesity Prevention Services. Rask, Kimberly J.; Gazmararian, Julie A.; Kohler, Susan S.; Hawley, Jonathan N.; Bogard, Jenny; Brown, Victoria A. // Journal of Obesity;2013, Vol. 2013, p1 

    Childhood obesity is a recognized public health crisis.This paper reviews the lessons learned from a voluntary initiative to expand insurance coverage for childhood obesity prevention and treatment services in the United States. In-depth telephone interviews were conducted with key informants...

  • Tracking of overweight from early childhood to adolescence in cohorts born 1988 and 1994: overweight in a high birth weight population. Johannsson, E.; Arngrimsson, S. A.; Thorsdottir, I.; Sveinsson, T. // International Journal of Obesity;Aug2006, Vol. 30 Issue 8, p1265 

    Objective:To investigate the prevalence and tracking of overweight and obesity in childhood cohorts born 1988 and 1994 in a population of high birth weight.Subjects:Icelandic cohorts born in 1988 and 1994.Materials and methods:Out of 1328, 9- and 15-year-old children from 18 randomly selected...

  • Rethinking Obesity Counseling: Having the French Fry Discussion. Bonnet, Jonathan; George, Aaron; Evans, Pippa; Silberberg, Mina; Dolinsky, Diana // Journal of Obesity;2014, p1 

    Childhood obesity is a complex problem that warrants early intervention. General recommendations for obesity prevention and nutrition counseling exist. However, these are notably imprecise with regard to early and targeted interventions to prevent and treat obesity in pediatric populations. This...

  • Is the Metabolically Healthy Obesity Phenotype an Irrelevant Artifact for Public Health? Rey-López, Juan Pablo; Fornias de Rezende, Leandro; Hérick de Sá, Thiago; Stamatakis, Emmanuel // American Journal of Epidemiology;11/1/2015, Vol. 182 Issue 9, p737 

    Some obese persons do not develop (at least in the short term) the metabolic complications of obesity that are thought to be causally linked to cardiovascular events or premature mortality. This phenomenon has been termed "metabolically healthy obesity" (MHO), and it has received much attention...

  • First lessons from the Kiel Obesity Prevention Study (KOPS). Danielzik, S.; Pust, S.; Landsberg, B.; Müller, M. J. // International Journal of Obesity;Sep2005 Supplement 2, Vol. 29, pS78 

    Aims:Prevention of obesity is a public health agenda. There are only few longitudinal studies on prevention of overweight in children. The Kiel Obesity Prevention Study (KOPS) intends to characterise the determinants of childhood overweight and the effect of preventive measures within schools as...


Read the Article


Sign out of this library

Other Topics