TITLE

Emergency Surgery of the Abdominal Aorta in a Porcine Model: Two Sequential Experiments

AUTHOR(S)
Lozano, Francisco S.; Rodríguez, José M.; García-Criado, Francisco J.; Gonzalez-Porras, Jose R.; Sanchez-Guijo, Fermin M.; Sanchez-Conde, Pilar; García-Sanchez, Jose E.
PUB. DATE
April 2008
SOURCE
World Journal of Surgery;Apr2008, Vol. 32 Issue 4, p642
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of this study was to design an aggressive nonlethal animal model that would simulate surgical treatment of the abdominal aorta with a view to studying the systemic inflammatory response. Fourteen pigs were subjected to two sequential experiments. Experiment A was performed to determine the response to two degrees of hemorrhage: (A1) 40% bleeding; and (A2) 60% bleeding over 15 minutes followed by midline laparotomy and aortic dissection. Experiment B included two methods of aortic repair: (B1) aortic resection and replacement with a prosthesis; and (B2) aortic bypass without aortic resection. In the latter two groups, suprarenal aortic cross-clamping was placed for 30 minutes after a 40% hemorrhage. We analyzed various inflammatory markers and mortality. The 40% bleeding (vs. 60%) elicited a smaller decrease in mean arterial pressure (110 ± 6 vs. 89 ± 9 mmHg) but did not cause irreversible shock or mortality. After the 40% hemorrhage, the B1 aortic repair caused two cases of paraplegia. We have developed a model to study the combined effect of bleeding and aortic cross-clamping.
ACCESSION #
31295195

 

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