TITLE

Mycobacterial T Cell Responses in HIV-Infected Patients with Advanced Immunosuppression

AUTHOR(S)
Hammond, Abdulrahman S.; McConkey, Samuel J.; Hill, Philip C.; Crazier, Sarah; Klein, Michèl R.; Adegbola, Richard A.; Rowland-Jones, Sarah; Brookes, Roger H.; Whittle, Hilton; Jaye, Assan
PUB. DATE
January 2008
SOURCE
Journal of Infectious Diseases;1/15/2008, Vol. 197 Issue 2, p295
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Antimycobacterial T cell reactivity at different stages of HIV infection was investigated. Subjects were screened with purified protein derivative (PPD), early secreted antigenic target (ESAT)-6, and culture filtrate protein (CFP)-10 antigens for interferon (IFN)-7-producing effector T cell responses by direct cx vivo enzyme-linked immunospot (ELISpot) assay. The proportion of responders to PPD tuberculin decreased with a reduction in CD4 T cell count, whereas the proportion of responder to ESAT-6 and CFP-10 did not. The main sources of IFN-y secretion were CD4 cells, and the relative responses to ESAT-6 and CFP-10 significantly increased in HIV-infected patients with decreasing CD4 cell count. This may reflect early signs of reactivation, reinfection, or a restricted, inefficient immune response to Mycobacterium tuberculosis.
ACCESSION #
31272841

 

Related Articles

  • Glutathione and Adaptive Immune Responses against Mycobacterium tuberculosis Infection in Healthy and HIV Infected Individuals. Guerra, Carlos; Morris, Devin; Sipin, Andrea; Kung, Steven; Franklin, Mesharee; Gray, Dennis; Tanzil, Michelle; Guilford, Frederick; Khasawneh, Fadi T.; Venketaraman, Vishwanath // PLoS ONE;2011, Vol. 6 Issue 12, p1 

    Glutathione (GSH), a tripeptide antioxidant, is essential for cellular homeostasis and plays a vital role in diverse cellular functions. Individuals who are infected with Human immuno deficiency virus (HIV) are known to be susceptible to Mycobacterium tuberculosis (M. tb) infection. We report...

  • Early Depletion of Mycobacterium tuberculosis-Specific T Helper 1 Cell Responses after HIV-1 Infection. Geldmacher, Christof; Schuetz, Alexandra; Ngwenyama, Njabulo; Casazza, Joseph P.; Sanga, Erica; Saathoff, Elmar; Boehme, Catharina; Geis, Steffen; Maboko, Leonard; Singh, Mahavir; Minja, Fred; Meyerhans, Andreas; Koup, Richard A.; Hoelscher, Michael // Journal of Infectious Diseases;12/1/2008, Vol. 198 Issue 11, p1590 

    Background. The acid-fast bacillus Mycobacterium tuberculosis is often the first manifestation of acquired immunodeficiency syndrome in patients infected with human immunodeficiency virus (HIV). This study was conducted to better understand the mechanism underlying M. tuberculosis-specific...

  • Depressed T-Cell Interferon-gamma Responses in Pulmonary Tuberculosis: Analysis of Underlying Mechanisms and Modulation with Therapy. Hirsch, Christina S.; Toossi, Zahra; Othieno, Catherine; Johnson, John L.; Schwander, Stephan K.; Robertson, Steven; Wallis, Robert S.; Edmonds, Kay; Okwera, Alphonse; Mugerwa, Roy; Peters, Pierre // Journal of Infectious Diseases;12/1/99, Vol. 180 Issue 6, p2069 

    Immunological and clinical profiles were evaluated in 2 groups: human immunodeficiency virus (HIV)-uninfected and HIV-infected patients, with newly diagnosed pulmonary tuber-culosis (TB), and tuberculin-skin-test-reactive healthy control subjects. HIV-uninfected patients with TB were also...

  • Association of Toll-Like Receptor 4 Asp299Gly and Thr399Ile Polymorphisms with Increased Infection Risk in Patients with Advanced HIV-1 Infection. Papadopoulos, Antonios I.; Ferwerda, Bart; Antoniadou, Anastasia; Sakka, Vissaria; Galani, Lambrini; Kavatha, Dimitra; Panagopoulos, Periklis; Poulakou, Garyphalia; Kanellakopoulou, Kyriaki; van der Meer, Jos W. M.; Giamarellos-Bourboulis, Evangelos J.; Netea, Mihai G. // Clinical Infectious Diseases;7/15/2010, Vol. 51 Issue 2, p242 

    Background. The Toll-like receptor 4 (TLR4) is an essential component of the innate immune response to various microorganisms. We investigated the association between TLR4 polymorphism and the risk of acquiring severe infections, in patients with human immunodeficiency virus (HIV)-1 infection....

  • The PGRS domain from PE_PGRS33 of Mycobacterium tuberculosis is target of humoral immune response in mice and humans. Cohen, Ingrid; Parada, Cristina; Acosta-Gío, Enrique; Espitia, Clara // Frontiers in Immunology;May2014, Vol. 5, p1 

    The PE_PGRS33 protein is a member of the PE family, which encompasses the PE and the PE_PGRS subfamilies. Among PE_PGRS's, this protein is one of the most studied antigens and its immunomodulatory properties are influence by both PE and PGRS domains. However, the contribution of these domains to...

  • Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting.  // BMC Infectious Diseases;2012, Vol. 12 Issue 1, p10 

    The article presents a study focusing on the potential of novel mycobacterium tuberculosis (M.tb) infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting. As stated, in response to the continued pressure mounted by host immune responses in the course of M.tb...

  • Tuberculosis testing among populations with high HIV risk in Tijuana, Baja California, Mexico. Velasquez, Michele G.; Laniado-Laborin, Rafael; Rodwell, Timothy C.; Cerecer, Paris; Lozada, Remedios; Cuevas-Mota, Jazmine; Burgos, Jose Luis; Garfein, Richard S. // Pan American Journal of Public Health;Jul2012, Vol. 32 Issue 1, p30 

    Objective. To assess the prevalence of prior tuberculin skin testing (TST) among populations at risk for HIV infection in Tijuana, Mexico, and to identify factors associated with TST. Methods. Sex workers, injection drug users, noninjecting drug users, and homeless persons ≥ 18 years old...

  • Immunophenotypic characterisation of peripheral T lymphocytes in pulmonary tuberculosis. Abba, Abdullah A. // Journal of Postgraduate Medicine;Jan-Mar2008, Vol. 54 Issue 1, p7 

    Background: The cellular immune response plays an important role in determining the outcome of infection and disease in Mycobacterium tuberculosis. Many studies of these disease interactions yield contradictory results. Aim: This study aims at determining the changes that take place in the...

  • Initiation and regulation of T-cell responses in tuberculosis. Urdahl, K. B.; Shafiani, S.; Ernst, J. D. // Mucosal Immunology (1933-0219);May2011, Vol. 4 Issue 3, p288 

    Tuberculosis (TB) poses a great challenge to immunologists, as it represents a chronic infection characterized by persistence of the pathogen despite development of antigen-specific immune responses. Among the characteristics of adaptive immune responses to Mycobacterium tuberculosis is a delay...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics