Mycobacterial T Cell Responses in HIV-Infected Patients with Advanced Immunosuppression

Hammond, Abdulrahman S.; McConkey, Samuel J.; Hill, Philip C.; Crazier, Sarah; Klein, Michèl R.; Adegbola, Richard A.; Rowland-Jones, Sarah; Brookes, Roger H.; Whittle, Hilton; Jaye, Assan
January 2008
Journal of Infectious Diseases;1/15/2008, Vol. 197 Issue 2, p295
Academic Journal
Antimycobacterial T cell reactivity at different stages of HIV infection was investigated. Subjects were screened with purified protein derivative (PPD), early secreted antigenic target (ESAT)-6, and culture filtrate protein (CFP)-10 antigens for interferon (IFN)-7-producing effector T cell responses by direct cx vivo enzyme-linked immunospot (ELISpot) assay. The proportion of responders to PPD tuberculin decreased with a reduction in CD4 T cell count, whereas the proportion of responder to ESAT-6 and CFP-10 did not. The main sources of IFN-y secretion were CD4 cells, and the relative responses to ESAT-6 and CFP-10 significantly increased in HIV-infected patients with decreasing CD4 cell count. This may reflect early signs of reactivation, reinfection, or a restricted, inefficient immune response to Mycobacterium tuberculosis.


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