Processing, characterisation, and biocompatibility of zinc modified metaphosphate based glasses for biomedical applications

Abou Neel, Ensanya A.; O'Dell, Luke A.; Smith, Mark E.; Knowles, Jonathan C.
April 2008
Journal of Materials Science: Materials in Medicine;Apr2008, Vol. 19 Issue 4, p1669
Academic Journal
Bulk and structural properties of zinc oxide (0 up to 20 mol%) containing phosphate glasses, developed for biomedical applications, were investigated throughout this study using differential thermal analysis (DTA), differential scanning calorimetry, X-ray powder diffraction and 31P and 23Na MAS NMR. Surface wettability and MG63 viability were also considered for surface characterisation of these glasses. The results indicated that incorporation of zinc oxide as a dopant into phosphate glasses produced a significant increase in density; however, the thermal properties presented in glass transition, and melting temperatures were reduced. NaZn(PO3)3 was detected in the X-Ray Powder Diffraction Analysis (XRD) trace of zinc containing glasses, and the proportion of this phase increased with increasing zinc oxide content. NaCa(PO3)3 as a second main phase and CaP2O6 in minor amounts were also detected. The 31P and 23Na MAS NMR results suggested that the relative abundances of the Q1 and Q2 phosphorus sites, and the local sodium environment were unaffected as CaO was replaced by ZnO in this system. The replacement of CaO with ZnO did seem to have the effect of increasing the local disorder of the Q2 metaphosphate chains, but less so for the Q1 chain-terminating sites which were already relatively disordered due to the proximity of modifying cations. Glasses with zinc oxide less than 5 mol% showed higher surface wettability, while those with 5 up to 20 mol% showed comparable wettability as zinc oxide free glasses. Regardless of the high hydrophilicity and surface reactivity of these zinc oxide containing glasses, they had lower biocompatibility, in particular 10–20 mol% ZnO, compared to both zinc free glasses and Thermanox®. This may be associated with the release of significant amount of Zn2+ enough to be toxic to MG63.


Related Articles

  • Physical and biocompatibility studies of novel titanium dioxide doped phosphate-based glasses for bone tissue engineering applications. Abou Neel, E. A.; Knowles, J. C. // Journal of Materials Science: Materials in Medicine;Jan2008, Vol. 19 Issue 1, p377 

    This study investigated doping titanium dioxide (TiO2) into phosphate glasses, 50 P2O5–30 CaO–20 Na2O, to control their degradation rate and enhance their biological response to be suitable scaffolds for bone tissue engineering applications. The thermal and structural properties...

  • Thermal studies of ZnO-BO-PO-TeO glasses. Mošner, P.; Vosejpková, K.; Koudelka, L.; Beneš, L. // Journal of Thermal Analysis & Calorimetry;Mar2012, Vol. 107 Issue 3, p1129 

    The effect of TeO additions on the thermal behaviour of zinc borophosphate glasses were studied in the compositional series (100 − x)[0.5ZnO-0.1BO-0.4PO]- xTeO by differential scanning calorimetry, thermodilatometry and heating microscopy thermal analysis. The addition of TeO to the...

  • Thermal analysis, spectral characterization and refractive index studies of lithium doped PbO-ZnO-B2O3 glass. Rajaramakrishna, R.; Lakshmikantha, R.; Anavekar, R. V. // AIP Conference Proceedings;6/5/2012, Vol. 1447 Issue 1, p541 

    Lithium containing lead zinc borate glasseshave been prepared by melt quenching technique. X-ray diffraction reveals the amorphous nature of the glass. Differential scanning calorimeter (DSC) study was carried out in the temperature range RT to 600°C temperature and found glass transition...

  • Dynamic Mechanical Behavior and Thermal Characterization of Biofilms Based on Starch Modified by Fungi Isolates. Rodriguez, Arturo; Ghosh, Subrata; Jeng, Robert; Sain, Mohini // Journal of Polymers & the Environment;Sep2010, Vol. 18 Issue 3, p430 

    Starches modified by Ophiostoma spp . have been investigated to develop bio-materials with enhanced mechanical and physical properties for thermoplastic applications. In this study, glass transition temperature (T) of modified starches was investigated in both dynamic mechanical analyzer (DMA)...

  • Kinetics of phase transition and thermal stability in SeTeZn ( x = 2, 4, 6, 8, and 10) glasses. Naqvi, S.; Saxena, N. // Journal of Thermal Analysis & Calorimetry;Jun2012, Vol. 108 Issue 3, p1161 

    SeTeZn ( x = 2, 4, 6, 8, and 10) glasses have been prepared using conventional melt quenching technique. The kinetics of phase transformations (glass transition and crystallization) have been studied using differential scanning calorimetry (DSC) under non-isothermal condition at five different...

  • Scientific approach.  // Engineer (00137758);1/28/2005, Vol. 293 Issue 7667, special section p7 

    Features the Biomaterials and Tissue Engineering center for industrial collaboration in England. Goal of helping companies understand the impact of emerging medical device technologies; Services offered; Access to revolutionary approaches to drug delivery.

  • Metastable Biocompatibility: A New Approach. Williams, David // Medical Device Technology;May/Jun2007, Vol. 18 Issue 3, p8 

    The article examines the performance of biomaterials by viewing their metastable concept not their stable state. The performance was further explored in the context of long-term implantable medical devices and biocompatibility failures. However, it was found out that controlling biocompatibility...

  • A new method for the preparation of bioactive calcium phosphate films hybridized with 1α,25-dihydroxyvitamin D3. Jae-Young Jung; Yun-Jung Hong; Yong Seok Choi; Sunjoo Jeong; Woo-Kul Lee // Journal of Materials Science: Materials in Medicine;Dec2009, Vol. 20 Issue 12, p2441 

    The primary goal of this investigation was to develop a calcium phosphate film hybridized with 1α,25-dihydroxyvitamin D3 for the improvement of osteoconductivity of bone substitutes. The hybrid films (hCaP) were prepared at the different concentrations of 1 × 10−10, 1 ×...

  • Mechanical properties of three different compositions of calcium phosphate bioceramic following immersion in Ringer’s solution and distilled water. Hsu, Y. H.; Turner, I. G.; Miles, A. W. // Journal of Materials Science: Materials in Medicine;Dec2009, Vol. 20 Issue 12, p2367 

    Dissolution tests were carried out to compare the mechanical properties of calcium phosphate based bioceramics with different compositions, before and after ageing for various time periods in Ringer’s solution (pH 7.2) or distilled water (pH 7.2 and 4.0) at 37°C. The results indicate...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics