TITLE

Comparison of an experimental bone cement with surgical Simplex® P, Spineplex® and Cortoss®

AUTHOR(S)
Boyd, D.; Towler, M. R.; Wren, A.; Clarkin, O. M.
PUB. DATE
April 2008
SOURCE
Journal of Materials Science: Materials in Medicine;Apr2008, Vol. 19 Issue 4, p1745
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Conventional polymethylmethacrylate (PMMA) cements and more recently Bisphenol-a-glycidyl dimethacrylate (BIS-GMA) composite cements are employed in procedures such as vertebroplasty. Unfortunately, such materials have inherent drawbacks including, a high curing exotherm, the incorporation of toxic components in their formulations, and critically, exhibit a modulus mismatch between cement and bone. The literature suggests that aluminium free, zinc based glass polyalkenoate cements (Zn-GPC) may be suitable alternative materials for consideration in such applications as vertebroplasty. This paper, examines one formulation of Zn-GPC and compares its strengths, modulus, and biocompatibility with three commercially available bone cements, Spineplex®, Simplex® P and Cortoss®. The setting times indicate that the current formulation of Zn-GPC sets in a time unsuitable for clinical deployment. However during setting, the peak exotherm was recorded to be 33°C, the lowest of all cements examined, and well below the threshold level for tissue necrosis to occur. The data obtained from mechanical testing shows the Zn-GPC has strengths of 63 MPa in compression and 30 MPa in biaxial flexure. Importantly these strengths remain stable with maturation; similar long term stability was exhibited by both Spineplex® and Simplex® P. Conversely, the strengths of Cortoss® were observed to rapidly diminish with time, a cause for clinical concern. In addition to strengths, the modulus of each material was determined. Only the Zn-GPC exhibited a modulus similar to vertebral trabecular bone, with all commercial materials exhibiting excessively high moduli. Such data indicates that the use of Zn-GPC may reduce adjacent fractures. The final investigation used the well established simulated body fluid (SBF) method to examine the ability of each material to bond with bone. The results indicate that the Zn-GPC is capable of producing a bone like apatite layer at its surface within 24 h which increased in coverage and density up to 7 days. Conversely, Spineplex®, and Simplex® P exhibit no apatite layer formation, while Cortoss® exhibits only minimal formation of an apatite layer after 7 days incubation in SBF. This paper shows that Zn-GPC, with optimised setting times, are suitable candidate materials for further development as bone cements.
ACCESSION #
31244623

 

Related Articles

  • A room-temperature autonomically-healing PMMA bone cement: influence of composition on fatigue crack propagation rate. Lewis, Gladius; Wellborn, Brandon; Jones II, LeRoy; Biggs, Patrick // Journal of Applied Biomaterials & Biomechanics;May2009, Vol. 7 Issue 2, p90 

    Purpose: To test two hypotheses. First, autonomic healing is achievable in a commercially available poly (methyl methacrylate) bone cement brand that is widely used to anchor total joint replacements. Secondly, in this self-healing cement, the fatigue crack propagation (FCP) rate is critically...

  • NEW MATERIAL FOR SOMATO-PROSTHESIS. BARNHART, GEORGE W.; ROBINSON, JOHN E. // Journal of Dental Research;Sep1958, Vol. 37 Issue 5, p948 

    This article discusses the results of a research study conducted to determine the efficacy of a material made in part of silicone rubber and and methyl methacrylate powders in the construction of somato-prostheses. Desirable qualities of the material are noted as including its flexibility,...

  • Potential Use of One-Phase Poly (methyl methacrylate) in Dental Implants. ZAKI, HUSSEIN S.; KAMEL, IHAB L. // Journal of Dental Research;Mar1976, Vol. 55 Issue 2, p272 

    Through compounding and molding techniques, variation of porosity and the resulting effect on the mechanical properties of one-phase poly(methyl methacrylate) (PMMA) were studied. Characterization of the composites developed was pursued by correlating the microstructure with the physical and...

  • On the mechanical properties of bovine serum albumin (BSA) adhesives. Berchane, N. S.; Andrews, M. J.; Kerr, S.; Slater, N. K. H.; Jebrail, F. F. // Journal of Materials Science: Materials in Medicine;Apr2008, Vol. 19 Issue 4, p1831 

    Biological adhesives, natural and synthetic, are of current active interest. These adhesives offer significant advantages over traditional sealant techniques, in particular, they are easier to use, and can play an integral part in the healing mechanism of tissue. Thus, biological adhesives can...

  • Propagation of fatigue cracks in acrylic bone cements containing different radiopaque agents. Manero, J. M.; Ginebra, M. P.; Gil, F. J.; Planell, J. A.; Delgado, J. A.; Morejon, L.; Artola, A.; Gurruchaga, M.; Goñ, I.; Goñi, I // Proceedings of the Institution of Mechanical Engineers -- Part H;May2004, Vol. 218 Issue 3, p167 

    In this work three iodine-containing monomers were proposed as new radiopaque agents for acrylic bone cements. In previous studies the addition of iodine-containing methacrylate monomers provided a statistically significant increase in tensile stress, fracture toughness and ductility, with...

  • Titanium back plate for a PMMA keratoprosthesis: clinical outcomes. Todani, Amit; Ciolino, Joseph; Ament, Jared; Colby, Kathryn; Pineda, Roberto; Belin, Michael; Aquavella, James; Chodosh, James; Dohlman, Claes // Graefe's Archive of Clinical & Experimental Ophthalmology;Oct2011, Vol. 249 Issue 10, p1515 

    Background/Purpose: To compare the rate of retroprosthetic membrane (RPM) formation in Boston Keratoprosthesis (BKPro) with polymethyl methacrylate (PMMA) versus titanium backplates. Design: Retrospective comparative chart review. Methods: Multicenter study population: a total of 78 eyes with...

  • In vitro investigation of heat transfer in calf spinal cord during polymethylmethacrylate application for vertebral body reconstruction. Aydın, Sabri; Bozdağ, Ergun; Sünbüloğlu, Emin; Ünalan, Halil; Hanci, Murat; Aydıngöz, Önder; Kuday, Cengiz; Aydin, Sabri; Bozdağ, Ergun; Sünbüloğlu, Emin; Unalan, Halil; Aydingöz, Onder // European Spine Journal;Mar2006, Vol. 15 Issue 3, p341 

    The objective of this experimental study was to investigate the temperature variations within the spinal cord of calf cadavers during polymethlymethacrylate (PMMA) application for vertebral body reconstruction. Cervical spines including the cervical spinal cord of ten fresh cadavers were used....

  • Incorporation of chitosan in acrylic bone cement: Effect on antibiotic release, bacterial biofilm formation and mechanical properties. Tunney, M. M.; Brady, A. J.; Buchanan, F.; Newe, C.; Dunne, N. J. // Journal of Materials Science: Materials in Medicine;Apr2008, Vol. 19 Issue 4, p1609 

    Bacterial infection remains a significant problem following total joint replacement. Efforts to prevent recurrent implant infection, including the use of antibiotic-loaded bone cement for implant fixation at the time of revision surgery, are not always successful. In this in vitro study, we...

  • Medical Applications of Plastics. LEONARD, FRED // Journal of Dental Research;Nov1966, Vol. 45 Issue 6, p1657 

    The article focuses on the medical applications of plastics in implants and tissue adhesives. It comments on biodegradable and biostable surgical repair polymers and surgical implants and on research into improving the stability of polymers against oxidative and hydrolytic responses. It mentions...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics