TITLE

Prognostic factors in paediatric acute liver failure

AUTHOR(S)
Ciocca, M.; Ramonet, M.; Cuarterolo, M.; López, S.; Cernadas, C.; Álvarez, F.
PUB. DATE
January 2008
SOURCE
Archives of Disease in Childhood;Jan2008, Vol. 93 Issue 1, p48
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To study the aetiology, outcome and prognostic indicators in children with acute liver failure (ALF). Study design: Retrospective chart review of 210 patients (107 males/103 females; median age: 5.33 years, range: 1-17.4). Patients were followed until discharge (group 1), death (group 2) or liver transplantation (LT; group 3). Data from group 1 were compared to data from the other two groups and Kings College criteria were also assessed. Results: Final diagnoses were: 128 (61%) hepatitis A, 68 (32%) indeterminate and 14 (7%) others. The characteristics of patients who survived (n = 59), died (n = 61) and underwent LT (n = 90) were analysed. In multivariate analysis, prothrombin time and encephalopathy III/IV were the most significant parameters suggesting a high likelihood of death. When King's College criteria were applied on admission in patients with and without transplantation, the positive predictive values were 96% and 95%, and the negative predictive values were 82% and 82%, respectively. Conclusions: Hepatitis A is the main cause of ALE in children in Argentina. Advanced encephalopathy and prolonged prothrombin time were significantly associated with death or need for LT. King's College criteria for predicting the outcome of ALF are applicable in children, including those with ALF due to hepatitis A infection.
ACCESSION #
31220814

 

Related Articles

  • Clinical features of adult patients with secondary hemophagocytic lymphohistiocytosis from causes other than lymphoma: an analysis of treatment outcome and prognostic factors. Park, Han-Seung; Kim, Dae-Young; Lee, Je-Hwan; Lee, Jung-Hee; Kim, Sung-Doo; Park, Young-Hun; Lee, Jae; Kim, Bo; Jeon, Mijin; Kang, Young-Ah; Lee, Young-Shin; Seol, Miee; Lee, Yeon-Joo; Lim, Young-Suk; Jang, Seongsoo; Park, Chan-Jeoung; Chi, Hyun-Sook; Lee, Kyoo-Hyung // Annals of Hematology;Jun2012, Vol. 91 Issue 6, p897 

    Although hemophagocytic syndrome (HS) featuring secondary hemophagocytic lymphohistiocytosis (HLH) has a grave prognosis, little is known about the natural course of the disease. Patients who showed the clinical features of HLH as well as tissue-proven hemophagocytosis when seen at Asan Medical...

  • Task profile and risk of occupational hepatitis A infection in sewerage workers. Nuebling, Matthias; Hofmann, Friedrich // International Archives of Occupational & Environmental Health;Oct2001, Vol. 74 Issue 8, p589 

    Objective: The aim of the study was to assess to what extent parameters of task-related occupational exposure influence anti-hepatitis A virus (anti-HAV) seroprevalence in sewerage workers, using a new instrument for classification of exposure. Methods: A new instrument for the assessment of...

  • INFECTIOUS HEPATITIS. Weiss, Samuel // American Journal of Gastroenterology;May1954, Vol. 21 Issue 5, p411 

    Discusses about infectious hepatitis. Transmission of the virus; Roles of physicians and laboratories in the prevention and dissemination of the disease; Efficacy of the use of gamma globulin.

  • Guillain-Barré Syndrome Due to Hepatitis A. Çomoǧlu, Selçuk; Cesur, Mustafa // Turkish Journal of Medical Sciences;2006, Vol. 36 Issue 3, p185 

    Guillain-Barré syndrome (GBS) is reported frequently following hepatotrophic viruses, but its occurrence due to the hepatitis A virus has been rarely reported to date. We present a case of serologically positive acute hepatitis A infection associated with GBS. There was an increased protein...

  • Serum Immunoglobulin G Subclasses in Patients During Acute Hepatitis A. Muller, Christian; Godl, Irene; Leibl, Heinz; Eibi, Martha M. // Clinical Pediatrics;Aug1990, Vol. 29 Issue 8, p471 

    IgG subclasses were measured in sera of 47 patients with acute hepatitis A during the course of the disease. IgG1 and IgG3 serum levels were found to be elevated, whereas IgG2 and IgG4 subclass concentrations did not differ from that found in healthy control individuals. These findings indicate...

  • Semptomatik Hepatit A ve Hepatit A Komplikasyonu Olarak Kolestatik Hepatit. Kara, Ateş; Parlakay, Aslınur Özkaya; Akan, Ayşegül; Cengiz, A. Bülent; Ceyhan, Mehmet // Journal of Pediatric Infection / Cocuk Enfeksiyon Dergisi;Dec2009, Vol. 3 Issue 4, p165 

    Hepatitis A infection is an acute, self limitting disease due to infection of the liver by hepatitis A virus , an enterically trasmitted virus which is a member of the Picornaviridae family. The infection may be asymptomatic or cause an acute hepatitis syndrome of varying degrees of severity up...

  • Does Mutation of Hepatitis A Virus Exist in North India? Syed Husain; Syed Pasha; Ranjana Anand; Abdullah Chand; Sunil Polipalli; Shabeena Rehman; Premashis Kar // Digestive Diseases & Sciences;Feb2008, Vol. 53 Issue 2, p506 

    Abstract Background  Human hepatitis A, a widespread infectious disease that is hyperendemic in vast areas of the world, results in the infection of the liver. Different human HAV strains of diverse geographic origin are remarkably closely related. HAV exploits all known...

  • Serum Amyloid P-Component as a Marker of Liver Disease. Levo, Yoram; Shalit, Meir; Tur-Kaspa, Ran // American Journal of Gastroenterology;Jun1982, Vol. 77 Issue 6, p427 

    The P-component of amyloid is a normal serum protein designated SAP. In view of recent in vivo experiments that have suggested a possible role for the liver in the synthesis of SAP, we decided to evaluate the usefulness of its serum level as a marker of liver involvement. The study...

  • The ABC of Hepatitis. Liebke, Steve // Massage Australia;May2005, Issue 50, p20 

    Presents information on hepatitis A, B and C. Factors which cause hepatitis; Treatment for hepatitis; Transmission of hepatitis A.

Share

Read the Article

Other Topics