TITLE

Normal bone mineral content but unfavourable muscle/fat ratio in Klinefelter syndrome

AUTHOR(S)
Aksglaede, L.; Molgaard, C.; Skakkebæk, N. E.; Juul, A.
PUB. DATE
January 2008
SOURCE
Archives of Disease in Childhood;Jan2008, Vol. 93 Issue 1, p30
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To evaluate body composition and bone mineral content (BMC) in children and adolescents with Klinefelter syndrome (KS). Design: Retrospective cross-sectional study. Setting: Tertiary endocrine clinic at the University Hospital, Copenhagen. Patients: Eighteen untreated boys with KS and six boys with KS receiving androgen substitution with a median age of 11.0 years (range 4.3-18.6) participated in the study. Intervention: Dual energy x ray absorptiometry and anthropometric measurements were analysed. Main outcome measures: Lumbar and whole body BMC, lean body mass (LBM), body fat mass (BFM), body fat percentage (BF%), height and body mass index (BMI) were compared between treated and untreated boys with KS and compared to normal age-matched boys. Results: LBM (untreated -0.3 (-2.4 to +2.1) and treated +1.1 (-1.6 to +2.1)) was normal, while BFM (untreated +0.5 (-1.0 to +2.3), p = 0.02 and treated +1.6 (-0.2 to +2.4), p = 0.01) was significantly increased, all expressed as standard deviation scores. Lumbar bone mineral density (BMD; untreated -0.4 (-3.1 to +0.9) and treated +1.0 (-1.4 to +3.0)) and whole body BMC (untreated +0.1 (-1.8 to +3.3) and treated +1.5 (-1.1 to +2.5)) were normal. Conclusion: We found significantly increased BFM and BF% despite normal LBM, suggesting the presence of an unfavourable muscle/fat ratio. Lumbar BMD and whole body BMC were normal. These findings suggest that the unfavourable metabolic profile seen in adult KS may already be present in childhood as evidenced by the increased fat mass, whereas the reported low BMD seems to develop after puberty.
ACCESSION #
31220810

 

Related Articles

  • Comparing several equations that predict peak VO2 using the 20-m multistage-shuttle run-test in 8-10-year-old children. Melo, Xavier; Santa-Clara, Helena; Almeida, José; Carnero, Elvis; Sardinha, Luís; Bruno, Paula; Fernhall, Bo; Almeida, José Pedro; Carnero, Elvis Alvarez; Sardinha, Luís Bettencourt; Bruno, Paula Marta // European Journal of Applied Physiology;Mar2011, Vol. 111 Issue 5, p839 

    This study compared the validity of reported equations as predictors of peak VO(2) in 8-10-year-old children. Participants (90 boys and girls aged 8-10 years) performed the multistage-shuttle-run-test (MSRT) and peak VO(2) was measured in field using a portable gas analyser. The equations...

  • The TRENDS Project: development of a methodology to reliably monitor the obesity epidemic in childhood. Rudolf, M. C. J.; Levine, R.; Feltbower, R.; Connor, A.; Robinson, M. // Archives of Disease in Childhood;Apr2006, Vol. 91 Issue 4, p309 

    Aims: The government has set a target to halt the rise in childhood obesity in those aged under 11 by 2010, but no system is in place to ascertain if this has been achieved. We aimed to develop a simple and reproducible methodology to monitor trends in childhood obesity. Methods: A purposive...

  • Risk Factors for Childhood Overweight in Offspring of Type 1 Diabetic Women With Adequate Glycemic Control During Pregnancy. Rupert, Maarten; Evers, Inge M.; De Vroede, Monique A. M. J.; De Valk, Harold W.; Heijnen, Cobi J.; Visser, Gerard H. A. // Diabetes Care;Nov2009, Vol. 32 Issue 11, p2099 

    OBJECTIVE -- Pregnancy in type 1 diabetic women remains a high-risk situation for both mother and child. In this study, we investigated long-term effects on body composition, prevalence of overweight, and insulin resistance in children of type 1 diabetic women who had had adequate glycemic...

  • Assessment of Pubertal Development in Iranian Girls. Rabbani, Ali; Motlagh, Mohammad-Esmaeil; Mohammad, Kazem; Ardalan, Gelayol; Maftoon, Farzaneh; Shahryari, Safiyeh; Khodaei, Shahnaz; Sotoudeh, Aria; Mohammadi, Mohammad-Reza; Gharaei, Javad Mahmoudi; Ziaaldini, Hassan; Kamali, Kobra; Motaghian, Moluk; Hosseini, Kheironesa Mostakhdemin; Salavati, Ali; Rabbani, Ahmad; Parvaneh, Nima // Iranian Journal of Pediatrics;Jun2010, Vol. 20 Issue 2, p160 

    Objective: We estimated pubertal development of 7,493 normal Iranian girls aged 6 to 20 years in a cross-sectional study. Methods: Pubertal stages were assessed according to Tanner. The mean ages to achieve secondary sexual characteristics as well as the mean age at menarche were estimated....

  • Change of Body Composition and Adipokines and Their Relationship with Insulin Resistance across Pubertal Development in Obese and Nonobese Chinese Children: The BCAMS Study. Lu Xu; Ming Li; Jinhua Yin; Hong Cheng; Miao Yu; Xiaoyuan Zhao; Xinhua Xiao; Jie Mi // International Journal of Endocrinology;2012, p1 

    A transient increase in insulin resistance (IR) is a component of puberty. We investigated the impact of body composition and adipokines on IR during puberty in Chinese children. This study included 3223 schoolchildren aged 6-18 years. IR was calculated using homeostasis model assessment...

  • Altered Breast Development in Young Girls from an Agricultural Environment. Guillette, Elizabeth A.; Conard, Craig; Lares, Fernando; Aguilar, Maria Guadalupe; McLachlan, John; Guillette Jr., Louis J. // Environmental Health Perspectives;Mar2006, Vol. 114 Issue 3, p471 

    In several human populations, the age at which female breast development begins is reported to have declined over the last five decades. Much debate has occurred over whether this reported decline has actually occurred and what factors contribute to it. However, geographical patterns reflecting...

  • Composição corporal e maturação somática de meninas atletas e não-atletas de natação da cidade do Recife, Brasil. Dos Santos, Marcosandré Moura; Leandro, Carol Góis; De Sá^Guimarães, Fernando José // Revista Brasileira de Saude Materno Infantil;abr-jun2007, Vol. 7 Issue 2, p175 

    Objectives: to describe body composition alteration patterns (body weight, height, body mass index - BMI), percentage of body fat and skinfold thickness, and to compare menarche's age of athletes and non-athletes. Methods: we evaluated 165 girls (aged 9 to 17 years old) non-athletes and athletes...

  • Pubertal development in daughters of women with pre-eclampsia. Ogland, Bjorn; Nilsen, Stein T.; Forman, Michele R.; Vatten, Lars J. // Archives of Disease in Childhood;Aug2011, Vol. 96 Issue 8, p740 

    Objective To compare clinical signs of puberty onset in daughters of pre-eclampsia and normotensive pregnancies. Design Population based follow-up study. Methods In a cohort of 120 daughters of pre-eclampsia pregnancies and 203 daughters of pregnancies without pre-eclampsia, pubic hair growth...

  • PREDICTION OF BODY COMPOSITION BASED ON SELF-ESTIMATED BODY IMAGE AND ACTIVITY INDEX RESULTS. Alexandru, Straton // Ovidius University Annals, Series Physical Education & Sport/Sci;2009, Vol. 9 Issue 1, p88 

    Objective: The aim of this study was to examine, if there is a reliable prediction capacity of self-estimated body image and activity index (AI) results, for future changes in body composition (body fat percentage (BF), body mass index (BMI) and abdominal circumference (AC)), in Romanian...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics