- 'Seaweed' human islet clinical trials underway. // Australian Nursing Journal;Apr2006, Vol. 13 Issue 9, p37
The article reports on the emergence of clinical trials that aim to assist people with type 1 diabetes through islet transplantation. The goal for researchers is to transplant islets containing 13 cells from the pancreases of deceased donors to people with type 1 diabetes who require multiple...
- Transplants pave the way for freedom from insulin. // Nursing Standard;4/13/2005, Vol. 19 Issue 31, p18
This article reports that islet allografts from two to four donors have been used in clinical trials since 2000 to reverse type 1 diabetes. The procedure is safer and easier than transplanting an entire pancreas. Researchers from the United States conducted a two-year clinical trial involving...
- CXCR1/2 inhibition enhances pancreatic islet survival after transplantation. Citro, Antonio; Cantarelli, Elisa; Maffi, Paola; Nano, Rita; Melzi, Raffaella; Mercalli, Alessia; Dugnani, Erica; Sordi, Valeria; Magistretti, Paola; Daffonchio, Luisa; Ruffini, Pier Adelchi; Allegretti, Marcello; Secchi, Antonio; Bonifacio, Ezio; Piemonti, Lorenzo // Journal of Clinical Investigation;Oct2012, Vol. 122 Issue 10, p1
Although long considered a promising treatment option for type 1 diabetes, pancreatic islet cell transformation has been hindered by immune system rejection of engrafted tissue. The identification of pathways that regulate post-transplant detrimental inflammatory events would improve management...
- Pancreatic islet cell tumor mimicking obstructive chronic pancreatitis: a case report. Wang, Xiaohong I.; Thomas MD, Jaiyeola; Adegboyega, Patrick; Zhang, Songlin // Internet Journal of Pathology;2010, Vol. 10 Issue 2, p7
Context: Pancreatic islet cell tumors are uncommon lesions, and nonfunctional islet cell tumors presenting with pancreatitis are extremely rare. Many patients with pancreatitis and islet cell tumors may initially present with acute attacks, which sometimes recur and the diagnosis of the tumors...
- In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. Ianus, Andreea; Holz, George G.; Theise, Neil D.; Hussain, Mehboob A. // Journal of Clinical Investigation;3/15/2003, Vol. 111 Issue 6, p843
Presents information on a study which demonstrated that bone marrow-derived cells populate pancreatic islets of Langerhans. Methodologies of the study; Results of the study; Discussion on the study.
- Xenotransplantation's benefits outweigh risks. Valdes Gonzalez, Rafael // Nature;11/21/2002, Vol. 420 Issue 6913, p268
Responds to comments about clinical trials of pancreatic islet xenotransplantation in Mexico. Existence of a general health law that regulates the conduct of all experimental investigations; Absence of an appropriate model for auto-immune diabetes in non-human primates.
- SPECIAL RESEARCH UPDATE: Islet Cell Transplantation. // Countdown;Fall2000, Vol. 21 Issue 4, p12
Updates on islet cell transplantation, which is considered as one of the most promising areas in research in the effort to cure diabetes. Complex challenges; Summaries of reports which reflect significant advances and promising new directions in islet cell transplantation research. INSETS: Ten...
- A Cure for Diabetes? // Prevention;Jan2002, Vol. 54 Issue 1, p116
Discusses how islet cell transplants can help cure type 1 diabetes.
- Researchers step toward diabetes cure. // Drug Store News;6/26/2000, Vol. 22 Issue 9, p114
Reports on the success of islet cell transplantation done to diabetics by the Islet Transplant Team at the University of Alberta. Process of the transplantation; Innovative use of conventional immunosuppressive drugs; Plans of the Juvenile Diabetes Foundation and the National Institutes of Health.