TITLE

Suppression of the Invasive Capacity of Human Breast Cancer Cells by Inhibition of Urokinase Plasminogen Activator via Amiloride and B428

AUTHOR(S)
Evans, Douglas M.; Sloan-Stakleff, Kimberly
PUB. DATE
May 2000
SOURCE
American Surgeon;May2000, Vol. 66 Issue 5, p460
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Inhibition of urokinase plasminogen activator (uPA) has been shown to suppress cancer cell invasion and metastasis in the laboratory setting by numerous investigators. Most studies have used murine cell lines implanted in syngeneic rodents or transfected human cell lines grown in immunocompromised laboratory hosts. In this study using Matrigel invasion chambers and two separate uPA inhibitors, amiloride and B428, the invasive capacity of unaltered human breast cancer cells was significantly suppressed. Cell proliferation was also suppressed to a lesser degree. These findings suggest that uPA inhibition may be a valid clinical approach to the control of the invasion and metastasis of human cancers.
ACCESSION #
3086415

 

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