TITLE

The effect of erythropoietin on healing of obstructive vs nonobstructive left colonic anastomosis: an experimental study

AUTHOR(S)
Moran, Munevver; Ozmen, M. Mahir; Duzgun, A. Polat; Gok, Riza; Renda, Nurten; Seckin, Selda; Coskun, Faruk
PUB. DATE
January 2007
SOURCE
World Journal of Emergency Surgery;2007, Vol. 2, p13
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Anastomotic leakage is an important problem following primary resection in the left colon and is even more prominent when obstruction is present. We aimed to evaluate the possible effects of erythropoietin on the healing of anastomosis under both obstructive and non-obstructive states. Methods: Forty male Wistar albino rats were divided into four groups. In group I, two cm left colonic resection and primary anastomosis were done. In group II, left colon were completely ligated and 24 hours later animals were re-operated for segmental resection. The same procedures were performed for rats in group III and IV in respect to group I and II and, 500 IU/kg a day erythropoietin were given in the latter two groups for seven days. For the quantative description of anastomotic healing mechanical, biochemical and histopathological parameters were employed on the seventh day and the animals were sacrificied. Results: Although erythropoietin had positive effects on bursting pressure in group IV when compared to group II, it has no effect in group III. Despite the increased tissue hydroxyproline levels in group IV, erythropoietin failed to show any effects in group III. Erythropoietin had positive effects on neovascularization, fibroblast proliferiation and storage of collagen in group IV. Conclusion: We failed to find any direct and evident effects of erythropoietin on healing of left colonic anastomosis. On the other hand, erythropoietin might prevent negative effects of obstruction on healing.
ACCESSION #
30095246

 

Related Articles

  • Jejunal diverticulosis with enterolith -- presenting as acute intestinal obstruction. Batra, Rajender Kumar; Sandhu, N. S. // Indian Journal of Surgery;Aug2005, Vol. 67 Issue 4, p219 

    The case of a 55-year male, who had acute small intestinal obstruction due to jejunal diverticuli and a large (5 × 4 cm) stone (enterolith) is presented here. The stone however could not be detected before surgery on plain X-ray abdomen. The patient was resuscitated and within a few hours...

  • Neostigmine.  // Reactions Weekly;6/15/2013, Issue 1457, p28 

    An abstract of the article "Colonic perforation following neostigmine administration," by D. S. H. Liu and colleagues is presented.

  • Mechanical Bowel Obstruction Due to Localized Extensive Amyloidotic Involvement in the Left Colon. Egeli, Tufan; Sokmen, Selman; Akarsu, Mesut; Gurel, Duygu // Indian Journal of Surgery;Apr2015 Supplement, Vol. 77, p94 

    Amyloidosis is a disorder caused by extracellular deposition of insoluble protein fibrils in various tissues. Colonic amyloidosis is a rare clinical manifestation which can mimic tumor, inflammatory bowel disease, or ischemic colitis. The most common symptoms of colonic amyloidosis include...

  • Recurrent Rectal Diverticulitis. Lundy, Jonathan B.; Edwards, Kurt D.; Parker, David M.; Rivera, David E. // American Surgeon;Jul2006, Vol. 72 Issue 7, p633 

    Diverticular involvement of the colon is very common in the United States. Patients present with asymptomatic diverticuli and may have complications of these, spanning the spectrum of uncomplicated diverticulitis to an acute surgical abdominal as a result of feculent peritonitis. We discuss a...

  • Experimental Study of the Diagnostic Potentialities of Bioimpedance Measurement in Acute Intestinal Obstruction. Rodin, A.; Pleshkov, V.; Leonov, S.; Bazhenov, S. // Bulletin of Experimental Biology & Medicine;Oct2013, Vol. 155 Issue 6, p810 

    The dynamics of impedance values of the small and large intestine, parietal peritoneum, and greater omentum was analyzed during different periods of experimental acute intestinal obstruction. The impedance was below the normal, which indicated progressive microcirculatory disorders and necrosis...

  • Complications of Meckel's diverticula in adults. Dumper, Jaymi; Mackenzie, Shawn; Mitchell, Philip; Sutherland, Francis; Quan, May Lynn; Mew, Daphne // Canadian Journal of Surgery;Oct2006, Vol. 49 Issue 5, p353 

    The article discusses the common complications of Meckel's diverticulum in adults. Meckel's diverticulum is a remnant of the vitelline duct and a normal anatomic variant found in 2% of the population. The most common complication in adult patients is intestinal obstruction, with incidence rate...

  • Unexpected cause of large bowel obstruction: Colonic bezoar. Bala, Miklosh; Appelbaum, Liat; Almogy, Gidon // Internet Journal of Gastroenterology;2008, Vol. 7 Issue 2, p3 

    Colonic bezoars as a cause of obstruction have not been widely described in the literature, so no conclusions can be drawn based on available data. We present a case of large bowel obstruction in an adult blind patient caused by a colonic mass suspicious for tumor or bezoar by its radiological...

  • Transverse colon volvulus in a 15 year old boy and the review of the literature. Rahbour, Goher; Ayantunde, Abraham; Ullah, Muhammad Rehan; Arshad, Sobia; Kerwat, Rajab // World Journal of Emergency Surgery;2010, Vol. 5, p19 

    We report a rare case of transverse colon volvulus in a fifteen year old boy with a review of the literature. This brings the total number of pediatric cases reported in the English literature to fifteen. This case is unusual in that no aetiological factor has been found, in contrast to the...

  • Volvulus of the Transverse Colon in a Child. Dadoo, R. C.; R. K. Keswani // Clinical Pediatrics;Aug1977, Vol. 16 Issue 8, p751 

    The article presents a case report on volvulus of the transverse colon in a child. A 12-year-old boy was hospitalized because of colicky abdominal pain for 5 days, constipation for 3 days and no vomiting. He had diarrhea for the 3 days preceding. There was no past history of any major illness or...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics