TITLE

Celiac disease

AUTHOR(S)
Holtmeier, Wolfgang; Caspary, Wolfgang F.
PUB. DATE
January 2006
SOURCE
Orphanet Journal of Rare Diseases;2006, Vol. 1, p3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Celiac disease is a chronic intestinal disease caused by intolerance to gluten. It is characterized by immune-mediated enteropathy, associated with maldigestion and malabsorption of most nutrients and vitamins. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. The main symptoms are: stomach pain, gas, and bloating, diarrhea, weight loss, anemia, edema, bone or joint pain. Prevalence for clinically overt celiac disease varies from 1:270 in Finland to 1:5000 in North America. Since celiac disease can be asymptomatic, most subjects are not diagnosed or they can present with atypical symptoms. Furthermore, severe inflammation of the small bowel can be present without any gastrointestinal symptoms. The diagnosis should be made early since celiac disease causes growth retardation in untreated children and atypical symptoms like infertility or neurological symptoms. Diagnosis requires endoscopy with jejunal biopsy. In addition, tissue-transglutaminase antibodies are important to confirm the diagnosis since there are other diseases which can mimic celiac disease. The exact cause of celiac disease is unknown but is thought to be primarily immune mediated (tissue-transglutaminase autoantigen); often the disease is inherited. Management consists in life long withdrawal of dietary gluten, which leads to significant clinical and histological improvement. However, complete normalization of histology can take years.
ACCESSION #
30093995

 

Related Articles

  • Activation and Inhibition of Transglutaminase 2 in Mice. Dafik, Laila; Albertelli, Megan; Stamnaes, Jorunn; Sollid, Ludvig M.; Khosla, Chaitan // PLoS ONE;Feb2012, Vol. 7 Issue 2, p1 

    Transglutaminase 2 (TG2) is an allosterically regulated enzyme with transamidating, deamidating and cell signaling activities. It is thought to catalyze sequence-specific deamidation of dietary gluten peptides in the small intestines of celiac disease patients. Because this modification has...

  • La enfermedad celiaca en los niños. Sotelo-Cruz, Norberto; Calderón de la Barca, Ana María // Revista Mexicana de Pediatria;nov/dic2012, Vol. 79 Issue 6, p281 

    Celiac disease is it an autoimmune disease caused by a permanent sensibility at gluten of wheat proteins and others like proteins, contents in rye, barley and oats, is necessary a genetic susceptibility. The clinical manifestation occurs during gluten introduction in the diet and includes:...

  • Activation and Inhibition of Transglutaminase 2 in Mice. Dafik, Laila; Albertelli, Megan; Stamnaes, Jorunn; Sollid, Ludvig M.; Khosla, Chaitan // PLoS ONE;Feb2012, Vol. 7 Issue 2, p1 

    Transglutaminase 2 (TG2) is an allosterically regulated enzyme with transamidating, deamidating and cell signaling activities. It is thought to catalyze sequence-specific deamidation of dietary gluten peptides in the small intestines of celiac disease patients. Because this modification has...

  • The Natural History of Gluten Sensitivity: Report of Two New Celiac Disease Patients Resulting From a Long-Term Follow-up of Nonatrophic, First-Degree Relatives. Niveloni, Sonia; Pedreira, Silvia; Sugai, Emilia; Vasquez, Horacio; Smecuol, Edgardo; Fiorini, Alcira; Cabanne, Ana; Dezi, Ruben; Valero, Jorge; Kogan, Zulema; Maurino, Eduardo; Bai, Julio C. // American Journal of Gastroenterology;Feb2000, Vol. 95 Issue 2, p463 

    OBJECTIVE: Early studies revealed that up to 50% of nonatrophic, first-degree relatives of celiac disease patients exhibit features of gluten sensitivity. However, whether these features progress to a fully expressed celiac disease remain partially known. Our aim was to report two new patients...

  • Refractory Coeliac Disease; Role of Nigella sativa as Immunomodulator. Osman, Muhamed T.; Al-Duboni, Ghada; Taha, Balsam I.; Muhamed, Luay A. // British Journal of Medicine & Medical Research;2012, Vol. 2 Issue 4, p527 

    Aim: The aim of this study was to assess the immunological and histological profiles of adult coeliac patients after commencing Nigella sativa (NS) oil with gluten free diet (GFD) for a period of 1 year ± 1month to prove its validity in treatment of refractory coeliac disease (CD)....

  • Role of transglutaminase 2 in celiac disease pathogenesis. Klöck, Cornelius; DiRaimondo, Thomas; Khosla, Chaitan // Seminars in Immunopathology;Jul2012, Vol. 34 Issue 4, p513 

    A number of lines of evidence suggest that transglutaminase 2 (TG2) may be one of the earliest disease-relevant proteins to encounter immunotoxic gluten in the celiac gut. These and other investigations also suggest that the reaction catalyzed by TG2 on dietary gluten peptides is essential for...

  • An ELIME assay for the rapid diagnosis of coeliac disease. Adornetto, Gianluca; Volpe, Giulia; Stefano, Alessia; Martini, Sonia; Gallucci, Giuseppina; Manzoni, Angelo; Bernardini, Sergio; Mascini, Marco; Moscone, Danila // Analytical & Bioanalytical Chemistry;Aug2012, Vol. 403 Issue 4, p1191 

    Coeliac disease (CD) is a gluten-induced autoimmune enteropathy found in genetically susceptible subjects. Because of the high number of undetected cases, rapid and cheaper screening methods are needed. Currently, the CD diagnosis involves the detection of anti-transglutaminase IgA antibodies...

  • Modeling of celiac disease immune response and the therapeutic effect of potential drugs. Demin, Oleg O.; Smirnov, Sergey V.; Sokolov, Victor V.; Cucurull-Sanchez, Lourdes; Pichardo-Almarza, Cesar; Victoria Flores, M.; Benson, Neil; Demin, Oleg V. // BMC Systems Biology;2013, Vol. 7 Issue 1, p1 

    Background: Celiac disease (CD) is an autoimmune disorder that occurs in genetically predisposed people and is caused by a reaction to the gluten protein found in wheat, which leads to intestinal villous atrophy. Currently there is no drug for treatment of CD. The only known treatment is...

  • Uveitis in celiac disease with an excellent response to gluten-free diet: third case described. Klack, Karin; Pereira, Rosa Maria Rodrigues; de Carvalho, Jozélio Freire // Rheumatology International;Mar2011, Vol. 31 Issue 3, p399 

    To describe the case of a patient with celiac disease who achieved a complete response to a gluten-free diet. A 28-year-old woman presented with diarrhea, oral ulcers, and refractory uveitis of 2.5-years duration. She was treated with prednisone, mydriatic drops, and infliximab with no response....

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics