TITLE

Acetyl salicylic acid augments functional recovery following sciatic nerve crush in mice

AUTHOR(S)
Subbanna, Prasanna Kumar T.; Prasanna, C. G.; Gunale, Bhagawat K.; Tyagi, Manoj G.
PUB. DATE
January 2007
SOURCE
Journal of Brachial Plexus & Peripheral Nerve Injury;2007, Vol. 2, p3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cyclin-dependent kinase 5 (CDK-5) appears to play a significant role in peripheral nerve regeneration as CDK-5 inhibition retards nerve regeneration following nerve crush. Anti-inflammatory drug acetyl salicylic acid elevates CDK-5 and reduces ischemia - reperfusion injury in cultured neurons. In this study we have evaluated the effect of acetyl salicylic acid on functional recovery following sciatic nerve crush in mice. Eighteen Swiss albino mice underwent unilateral sciatic nerve crush. Test animals received acetyl salicylic acid (100 mg/kg/day, n = 6 or 50 mg/kg/day, n = 6) and control animals (n = 6) received normal saline for 14 days following surgery. Functional recovery was assessed with improvement in Sciatic Function Index, nociception and gait. In comparison with normal saline treatment, acetyl salicylic acid (100 mg/kg/day) significantly improved functional recovery following sciatic nerve crush. Anti-inflammatory drug acetyl salicylic acid appears to be a promising agent for treating peripheral nerve injuries and hence elucidation of its neuroprotective pathways is necessary.
ACCESSION #
30093716

 

Related Articles

  • Regenerating complex nerves.  // Industrial Engineer: IE;Nov2015, Vol. 47 Issue 11, p10 

    The article focuses on a study by professor Blake Johnson and researchers from the Johns Hopkins University, the University of Maryland and the University of Minnesota to repair complex human nerve injuries. As per the study, researchers have used bioimaging technique called structured light...

  • Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response. Lindblom, Rickard P. F.; Berg, Alexander; Ström, Mikael; Aeinehband, Shahin; Dominguez, Cecilia A.; Nimer, Faiez Al; Abdelmagid, Nada; Heinig, Matthias; Zelano, Johan; Harnesk, Karin; Hübner, Norbert; Nilsson, Bo; Ekdahl, Kristina Nilsson; Diez, Margarita; Cullheim, Staffan; Piehl, Fredrik; Al Nimer, Faiez // Journal of Neuroinflammation;10/26/2015, Vol. 12, p1 

    Background: Activation of the complement system has been implicated in both acute and chronic states of neurodegeneration. However, a detailed understanding of this complex network of interacting components is still lacking.Methods: Large-scale global expression...

  • Difference in intraosseous blood vessel volume and number in osteoporotic model mice induced by spinal cord injury and sciatic nerve resection. Ding, Wen-Ge; Yan, Wei-hong; Wei, Zhao-Xiang; Liu, Jin-Bo // Journal of Bone & Mineral Metabolism;Jul2012, Vol. 30 Issue 4, p400 

    In the present study, we examined intraosseous blood vessel parameters of the tibial metaphysis in mice using microcomputed tomography (µCT) to investigate the relationship between post-nerve-injury osteoporosis and local intraosseous blood vessel volume and number. Mice were randomly divided...

  • Axonal Regeneration after Sciatic Nerve Lesion Is Delayed but Complete in GFAP- and Vimentin-Deficient Mice. Berg, Alexander; Zelano, Johan; Pekna, Marcela; Wilhelmsson, Ulrika; Pekny, Milos; Cullheim, Staffan // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Peripheral axotomy of motoneurons triggers Wallerian degeneration of injured axons distal to the lesion, followed by axon regeneration. Centrally, axotomy induces loss of synapses (synaptic stripping) from the surface of lesioned motoneurons in the spinal cord. At the lesion site, reactive...

  • Preferential and Comprehensive Reconstitution of Severely Damaged Sciatic Nerve Using Murine Skeletal Muscle-Derived Multipotent Stem Cells. Tamaki, Tetsuro; Hirata, Maki; Soeda, Shuichi; Nakajima, Nobuyuki; Saito, Kosuke; Nakazato, Kenei; Okada, Yoshinori; Hashimoto, Hiroyuki; Uchiyama, Yoshiyasu; Mochida, Joji // PLoS ONE;Mar2014, Vol. 9 Issue 3, p1 

    Loss of vital functions in the somatic motor and sensory nervous systems can be induced by severe peripheral nerve transection with a long gap following trauma. In such cases, autologous nerve grafts have been used as the gold standard, with the expectation of activation and proliferation of...

  • Inflammation: Coordinating antimicrobial activity and wound repair. Minton, Kirsty // Nature Reviews Immunology;Aug2012, Vol. 12 Issue 8, p552 

    The article discusses the antimicrobial peptides and/or proteins (AMPs) production in wound repair. It references the study "The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury," by Y. Lai and colleagues in the June 21, 2012 issue of...

  • The Effect of Pentoxifylline on Global Ischemia/Reperfusion Induced Spatial Memory Impairment in Estrous Phase of Female Wistar Rat. Khezri, Nooshin Panahi; Movassaghi, Shabnam; Sharifi, Zahra Nadia; Shafaroodi, Hamed; Ansarian, Ghazal // New Indian Journal of Surgery;Jul-Sep2012, Vol. 3 Issue 3, p162 

    Background The short discontinuance of cerebral blood flow causes permanent brain injury and behavioral dysfunction. The hippocampus, specifically the CA1 pyramidal cell layer, is highly vulnerable to ischemic injuries. There is no effective pharmacological strategy for improving brain tissue...

  • Soluble Factors from Lactobacillus reuteri CRL1098 Have Anti-Inflammatory Effects in Acute Lung Injury Induced by Lipopolysaccharide in Mice. Griet, Milagros; Zelaya, Hortensia; Mateos, Melina Valeria; Salva, Susana; Juarez, Guillermo Esteban; de Valdez, Graciela Font; Villena, Julio; Salvador, Gabriela Alejandra; Rodriguez, Ana Virginia // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    We have previously demonstrated that Lactobacillus reuteri CRL1098 soluble factors were able to reduce TNF-α production by human peripheral blood mononuclear cells. The aims of this study were to determine whether L. reuteri CRL1098 soluble factors were able to modulate in vitro the...

  • The Effect of Ultrasound on Acceleration of Peripheral Nerve Injury. Jahromy, F. Zareayan; Behnam, H.; Mansuri, K.; Rahimi, A. A.; Mobarakeh, J. Izadi // Journal of Biomedical Physics & Engineering;Dec2012, Vol. 2 Issue 4, p147 

    Background: Many people suffer from nerve injury. The time consuming nature of the treatments makes the condition worse. Therefore, finding a way to accelerate the process of nerve repair is very important. Objective: To determine the effect of ultrasound on the acceleration of crushed...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics