Extracellular ATP in asthma airway inflammation

Parekh, D.
February 2008
Thorax;Feb2008, Vol. 63 Issue 2, p140
Academic Journal
The article discusses the significance of extracellular ATP and purinergic signalling as mediators in asthma airway inflammation. Binding of ATP to purinergic receptors using experimental mice models push inflammatory chemotaxis and bronchospasm. Management of exogenous ATP among mice rises Th2-type sensitization in inhaled antigen, which shows that ATP can lead to the development of asthmatic sensitization through recruitment of Th2.


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