Role for Major Vault Protein in the innate immunity of respiratory epithelium

Jenkins, D.
February 2008
Thorax;Feb2008, Vol. 63 Issue 2, p107
Academic Journal
The article discusses the significance of Major Vault Protein (MVP) for innate immunity found in human respiratory epithelium. Insufficient MVP can increase weakness to infection. It recommends that cystic fibrosis transmembrane conductance regulator binding of bacterial lipopolysaccharide endorses recruitment of MVP to lipid rafts. As a result, it raises the epithelial internalization of P. aeruginosa.


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