Accuracy of 16-channel multi-detector row chest computed tomography with thin sections in the detection of metastatic pulmonary nodules

Kang, Moon Chul; Kang, Chang Hyun; Lee, Hyun Ju; Goo, Jin Mo; Kim, Young Tae; Kim, Joo Hyun
March 2008
European Journal of Cardio-Thoracic Surgery;Mar2008, Vol. 33 Issue 3, p473
Academic Journal
Abstract: Objectives: The inaccuracy of conventional CT makes open thoracotomy and manual palpation inevitable in pulmonary metastasectomy. However, the introduction of multi-detector row CT technology made it possible to detect pulmonary nodules with a diameter of 1mm. The purpose of this study was to investigate the accuracy of 1mm thin-section 16-channel multi-detector row CT (TSMDCT) in the detection of metastatic pulmonary nodules. Methods: Twenty-seven patients who underwent pulmonary metastasectomy between November 2005 and September 2006 were included in the study. The primary tumors were colorectal cancer (n =11), renal cell carcinoma (n =5), osteosarcoma (n =3), hepatocellular carcinoma (n =3), thymic tumor (n =2), bladder cancer (n =1), thyroid cancer (n =1), and primitive neuroectodermal tumor (n =1). TSMDCT was performed in all patients in order to evaluate the location and number of metastatic nodules. The patients were divided into osteosarcoma and non-osteosarcoma groups, and the accuracy of TSMDCT was evaluated by comparison with the pathologic diagnosis of metastatic nodules. Results: A total of 117 nodules were detected preoperatively by TSMDCT scanning, and 198 nodules were resected during the operation. A total of 101 nodules were pathologically confirmed to be metastatic nodules. In the osteosarcoma group, the sensitivity, specificity, positive predictive value, and negative predictive value were 34%, 93%, 92%, and 38%, respectively. In the non-osteosarcoma group, the sensitivity, specificity, positive predictive value, and negative predictive value were 97%, 54%, 64%, and 96%, respectively. Subgroup analysis in the non-osteosarcoma group revealed that nodule size over 5mm, number of metastatic nodules less than five, and disease-free interval over 24 months showed 100% sensitivity by preoperative TSMDCT. Conclusions: TSMDCT with 1mm thickness image reconstruction showed high detection rate of metastatic pulmonary nodules in the patients with non-osteosarcoma. In highly selected subgroups, TSMDCT detected all the metastatic nodules which manual palpation could detect. Further study on the application of TSMDCT in thoracoscopic metastasectomy should be performed.


Related Articles

  • AIDS update.  // Men's Health;Nov93, Vol. 8 Issue 8, p24 

    Discusses several developments in AIDS research. Testing to determine if a fat-based coating can minimize potentially toxic side effects of two chemotherapy drugs used to treat Kaposi's sarcoma; Early progress toward an anti-HIV vaccine; Clinical trials of a novel three-drug therapy for...

  • Some aspects of the pathogenesis of HIV-1-associated kaposi's sarcoma. Gallo, Robert C. // JNCI: Journal of the National Cancer Institute;05/06/98 Supplement Monograph 23, Vol. 90 Issue 9, p55 

    Presents information on a study which focuses on kaposi's sarcoma. Investigation of the role of human immunodeficiency virus type 1 (HIV-1) infection; Discussion on whether KS is hyperplastic or neoplastic; Findings from the study.

  • Human herpesvirus 8--the first human Rhadinovirus. Neipel, Frank; Albrecht, Jens-Christian; Fleckenstein, Bernard // JNCI: Journal of the National Cancer Institute;05/06/98 Supplement Monograph 23, Vol. 90 Issue 9, p73 

    Presents information on a study which focuses on the human herpesvirus 8 (HHV-8) of kaposi's sarcoma (KS)-associated herpesvirus as the first known human member of the genus Rhadionvirus. Where is Rhadionvirus found in KS; Detailed information on Rhadionvirus; Reference to the cloning and...

  • Deletion and translocation involving chromosome 3(p14) in two tumorigenic Kaposi's Sarcoma cell... Popescu, Nicholas C.; Zimonjic, Drazen B. // JNCI: Journal of the National Cancer Institute;4/3/96, Vol. 88 Issue 7, p450 

    Investigates whether the chromosomal changes that occurred in neoplastic Kaposi's sarcoma (KS) cell lines were random or nonrandom. Description of materials and methods used in the study; Origin cell cultures; Cell culture conditions; Chromosome G-banding.

  • Watch where you walk. Glausiusz, Josie // Discover;Apr94, Vol. 15 Issue 4, p26 

    Gives details on Kaposi's Sarcoma, a form of cancer. Physical description; Comparison with acquired immunodeficiency syndrome-related Kaposi; Statistical information on Kaposi's in gay men.

  • Experimental treatments flourish for KS patients. Nelson, Nancy J. // JNCI: Journal of the National Cancer Institute;7/19/95, Vol. 87 Issue 14, p1052 

    Reports on developments in research knowledge on Kaposi's sarcoma (KS) discussed by clinical oncologists, scientists and AIDS activists during a meeting in Bethesda, Maryland. Vascular endothelial cells as the most likely cell of origin for KS; Development and testing of drugs against KS;...

  • Respiratory medicine.  // Clinical & Investigative Medicine;Aug97 Supplement, Vol. 20, pS97 

    Presents an abstract of the research manuscript `Pulmonary Kaposi's sarcoma (PKS),' by E. Mate et al.

  • SHORT TAKES: San Francisco, CA.  // Advocate;8/19/82, Issue 349, p23 

    Reports on the formation of the San Francisco, California-based Kaposi's Sarcoma Research and Education Foundation Inc. to support research and community education on disease related to immune system deficiencies.

  • Killing of Sarcoma Cells by Proapoptotic Bcl-XS: Role of the BH3 Domain and Regulation by Bcl-XL. Mitra, Raj S; Benedict, Mary A; Qian, Dalong; Foreman, Kimberly E; Ekhterae, Daryoush; Nickoloff, Brian J; Nu´┐Żez, Gabriel // Neoplasia;Sep2001, Vol. 3 Issue 5, p437 

    Kaposi's sarcoma (KS) is the most common tumor affecting AIDS patients with over 20% of these patients afflicted by this disease. Previous studies have demonstrated that KS tumor cells predominantly express the prosurvival protein Bcl-XL compared with Bcl-2. In the current study, we have used an...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics