Applications of statins in cardiothoracic surgery: more than just lipid-lowering

Paraskevas, Kosmas I.
March 2008
European Journal of Cardio-Thoracic Surgery;Mar2008, Vol. 33 Issue 3, p377
Academic Journal
Summary: Statins exert several actions in cardiothoracic surgical procedures besides lipid-lowering. In patients undergoing coronary artery bypass grafting (CABG), statins improve bypass graft patency, perioperative as well as long-term mortality rates. In addition, statins reduce the number of postoperative complications and clinical events, revascularization rates and postoperative hospital stay (as well as associated costs). Furthermore, they are protective against de novo atrial fibrillation and renal dysfunction following CABG. In cardiac transplantation, statins decrease cardiac allograft vasculopathy and cardiac rejection rates. They are also associated with a significant reduction in mortality rates in cardiac transplant patients. According to the results of a meta-analysis, statins are associated with one life saved for every 8.5 heart transplant recipients treated for 1 year. Alternatively, routine statin treatment in cardiac transplant patients might have the potential to save 471 lives each year among the 4000 heart transplantation operations performed worldwide. The results from several studies suggest that statins may also play a role in heart valve surgery, lung transplantation, pulmonary resection and thoracic aortic aneurysm repair. Statin use is safe and cost-effective. Despite the multiple beneficial effects of statin therapy, there is evidence suggesting that a large percentage of cardiothoracic surgical patients are suboptimally treated with respect to statins. Risk management in these patients should be improved to reduce cardiovascular morbidity and mortality rates.


Related Articles

  • Add-on statin in postcode lottery row.  // Pulse;9/22/2003, Vol. 63 Issue 38, p4 

    Reports on the availability of add-on statin ezetimibe in Scotland. Details of an Executive decision to recommend the use of the drug in patient with high cholesterol levels; Issues related to statin prescribing.

  • BETTER THAN STATINS.  // Nutrition Action Health Letter;May2002, Vol. 29 Issue 4, p6 

    Reports on the results of a study on the use of statin drugs and a healthy diet to lower low-density lipoprotein cholesterol.

  • Statins and cardiac benefits.  // Medical Marketing & Media;Oct2001, Vol. 36 Issue 10, p19 

    Examines the drug properties of statins beyond diminishing cholesterol levels. Differences in the reactions of the drugs usage in terms of vascular disease; Reproduction of platelet activity and aggregation; Increase of bone formation and mineral density.

  • In This Issue.  // Clinical Pharmacology & Therapeutics;Apr2013, Vol. 93 Issue 4, p283 

    An introduction is presented in which the editor discusses various reports within the issue on topics including novel method of treatment of human disease, computational drug and statin allocation method.

  • Beware the Panacea. Slon, Steven // Saturday Evening Post;May/Jun2012, Vol. 284 Issue 3, p6 

    An introduction is presented to an article by Sharon Begley about statins in the current issue entitled "The Cholesterol Conundrum."

  • Choosing a statin. Glaser, Vicki // Patient Care for the Nurse Practitioner;Sep2000, Vol. 3 Issue 9, p70 

    Focuses on the factors to consider in choosing a statin. Guidelines on the use of statins for cholesterol-lowering therapy; Pharmacologic differences of statins; Chemical structure of statins; Information on statin metabolism; Adverse reactions to statins. INSET: Meeting the NCEP guidelines:...

  • Is The Lipid-Lowering Med Causing These Symptoms? Porterfiled, Linda M. // RN;Oct2003, Vol. 66 Issue 10, p91 

    Focuses on the possible side effects of statin drugs. Muscle weakness and painful joints experienced by a patient.

  • do you really need a cholesterol drug? Jaret, Peter // Health (Time Inc. Health);Oct2001, Vol. 15 Issue 8, p100 

    Provides information on lowering cholesterol levels. Advantage and disadvantages of the cholesterol-lowering drug statins; Benefits of a healthy diet and exercise as an alternative for such drugs; Recommendation for people at risk for heart disease. INSET: Margarine vs. butter: Spread softly.

  • Risks of a nonprescription lovastatin. Guharoy, Roy // American Journal of Health-System Pharmacy;7/15/2005, Vol. 62 Issue 14, p1444 

    Presents a letter to the editor on cholesterol-lowering drug lovastatin manufactured by Merck & Co. Inc.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics