Measuring the benefits of growth hormone therapy in children: a role for preference-based approaches?

Petrou, Stavros; McIntosh, Emma
February 2008
Archives of Disease in Childhood;Feb2008, Vol. 93 Issue 2, p95
Academic Journal
The article discusses the importance of growth hormones in addressing growth hormone deficiency in children in Great Britain. It revealed that recombinant human growth hormone revolutionised the management of children with hormonal growth deficiency, chronic renal insufficiency, Turner syndrome, Prader-Willi syndrome, small-forgestational-age status, idiopathic short stature and other growth disorders. Although such procedure produces some benefits including acceleration in linear growth, scientists found that it has its limitations as well. They found that they are unable to incorporate the several health changes that can result from growth hormone therapy including the increased risk of adverse effects including pigmentation and growth of nevi and gynecomastia.


Related Articles

  • Monitoring of concordance in growth hormone therapy. Kapoor, A. A.; Burke, S. A.; Sparrow, S. E.; Hughes, I. A.; Dunger, D. B.; Ong, K. K.; Acerini, C. L. // Archives of Disease in Childhood;Feb2008, Vol. 93 Issue 2, p147 

    Concordance with growth hormone (GH) therapy in 75 children was objectively assessed using data on GP prescriptions over 12 months. 23% missed >2 injections! week. Lower concordance was associated with longer duration on GH therapy (p<0.005), lack of choice of delivery device (p<0.005) and short...

  • Rapid recurrence of craniopharyngioma following recombinant human growth hormone replacement. Taguchi, Takafumi; Takao, Toshihiro; Iwasaki, Yasumasa; Pooh, Kyonghon; Okazaki, Mizuho; Hashimoto, Kozo; Terada, Yoshio // Journal of Neuro-Oncology;Nov2010, Vol. 100 Issue 2, p321 

    No abstract available.

  • Facilitating and understanding the family's choice of injection device for growth hormone therapy by using conjoint analysis. Ahmed, S. F.; Smith, W. A.; Blamires, C. // Archives of Disease in Childhood;Feb2008, Vol. 93 Issue 2, p110 

    Background: Conjoint analysis involves the measurement of consumer preferences between choice alternatives. Aims and objectives: To investigate the use of conjoint analysis in facilitating and understanding choice of growth hormone injection devices. Method and subjects: 56 patients and their...

  • The Efficacy of Growth Hormone Therapy on Children with Growth Hormone Deficiency Treated with Recombinant Human Growth Hormone. Essa, Kassim Rahi; Al-Jumaili, Ali Hasan; Ali Hasan, Waseem; Salih, Bushra Jaleel // Tikrit Medical Journal;Jun2010, Vol. 16 Issue 1, p184 

    The use of growth hormone (GH) in clinical endocrine practice is expanding and its role in the treatment of various clinical conditions is increasingly appreciated. Concurrently, concerns have been raised about the ethnical, economic, safety and efficacy of growth hormone and this study in this...

  • History of growth hormone therapy. Ayyar, Vageesh S. // Indian Journal of Endocrinology & Metabolism;Jul2011 Supplement 2, pS162 

    Although the importance of the pituitary gland for growth was recognized in late 19 century, Growth hormone (GH) therapy was made available for severely GH-deicient children and adolescents only in late 1950s. Use of GH for other conditions was limited because of the limited supply of human...

  • Treatment of Growth Hormone Deficiency in the Transition of Adolescence to Adulthood. Mauras, Nelly // Endocrine Today;10/25/2008 Growth & Growth Hormone, Vol. 6, p15 

    The article explores growth hormone (GH) deficiency treatments in adolescents as they mature into adulthood. It identifies the stage where GH deficiency persists and studies the efficacy of GH treatment during transition from adolescent to adulthood. It suggests to discontinue treatment for one...

  • "Anything you can do, I can do bigger?": the ethics and equity of growth hormone for small normal children. Gill, D. G. // Archives of Disease in Childhood;Mar2006, Vol. 91 Issue 3, p270 

    This paper argues against the use of growth hormone (GH) for small normal children (‘idiopathic’ short stature) with the following considerations: ethical (philosophical) grounds, cost-economic implications, and the rationale for treating normal physiological variation with a potent...

  • Growth hormone for adults. Hadden, David R. // Journal of the Royal Society of Medicine;Mar1997, Vol. 90 Issue 3, p122 

    The article discusses the role of the human pituitary growth hormone on growth promotion in growth-hormone deficient children and adults. Several experimental and clinical studies indicate that growth hormone is necessary for muscle regulation as well as bone and lipid metabolism. In Great...

  • Maintaining persistence and adherence with subcutaneous growth-hormone therapy in children: comparing jet-delivery and needle-based devices. Spoudeas, Helen A.; Bajaj, Priti; Sommerford, Nathan // Patient Preference & Adherence;2014, Vol. 8, p1255 

    Purpose: Persistence and adherence with subcutaneous growth hormone (GH; somatropin) therapy in children is widely acknowledged to be suboptimal. This study aimed to investigate how the use of a jet-delivery device, ZomaJet&≥174;, impacts on medication-taking behaviors compared to...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics