Hypothermia in VGKC antibody-associated limbic encephalitis

Jacob, S.; Irani, S. R.; Rajabally, Y. A.; Grubneac, A.; Walters, R. J.; Yazaki, M.; Clover, L.; Vincent, A.
February 2008
Journal of Neurology, Neurosurgery & Psychiatry;Feb2008, Vol. 79 Issue 2, p202
Academic Journal
Voltage-gated potassium channel antibody (VGKC-Ab)-associated limbic encephalitis (LE) is a recently described syndrome that broadens the spectrum of immunotherapy- responsive central nervous system disorders. Limbic encephalitis is typically characterised by a sub-acute onset of disorientation, amnesia and seizures, but the clinical spectrum is not yet fully defined and the syndrome could be under-diagnosed. We here describe the clinical profile of four patients with VGKC-Ab-associated LE who had intermittent, episodic hypothermia. One of the patients also described a prodrome of severe neuropathic pain preceding the development of limbic symptoms. Both of these novel symptoms responded well to immuno-suppressive therapy, with concurrent amelioration of amnesia/seizures.


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