TITLE

Statistical validation of the criteria for symptom remission in schizophrenia: Preliminary findings

AUTHOR(S)
Opler, Mark G. A.; Yang, Lawrence H.; Caleo, Sue; Alberti, Philip
PUB. DATE
January 2007
SOURCE
BMC Psychiatry;2007, Vol. 7, p35
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Published methods for assessing remission in schizophrenia are variable and none have been definitively validated or standardized. Andreasen et al (2005) suggest systematic operational criteria using eight PANSS items for which patients must score ≤ 3 (mild) for at least six months. Methods: Using data from a one year, multi-site clinical trial (n = 675) remission criteria were compared to total PANSS scores and other endpoints and demonstrate excellent agreement with overall clinical status. Results: Compared to total PANSS score of 60 points and other criteria, at time points > 6 months (8 and 12 months) the specificity of the remission criteria was 85%, i.e. of the patients who had a total score >60, 85% were classified as "not in remission." Sensitivity was also very high; 75% of patients with scores of <60 were classified as "in remission."Patients who dropped out of the trial were more likely not to be in remission prior to dropping out. Conclusion: These findings indicate that the remission criteria are both sensitive and specific indicators of clinical status. Additional analyses are required to determine if remission status predicts other outcomes, such as employment, independent living, and prognosis.
ACCESSION #
29962951

 

Related Articles

  • Computerised Tomography in Newly Diagnosed Schizophrenia and Schizophreniform Disorder. Rubin, Pia; Karle, Agnete; MøLler-Madsen, Susanne; Hertel, Charlotte; Povlsen, Uffe Juul; Noring, Ulla; Hemmingsen, Ralf // British Journal of Psychiatry;Nov93, Vol. 163, p604 

    Patients with newly diagnosed schizophrenia (n = 27) or schizophreniform disorder (n = 22) and 24 healthy volunteers were investigated by CT scan, the investigators being blind to subject status. The patients had never received medication or had been treated only briefly with neuroleptics. The...

  • Cognitive behavioural treatment of negative symptoms in schizophrenia patients: study design of the TONES study, feasibility and safety of treatment. Klingberg, Stefan; Wittorf, Andreas; Herrlich, Jutta; Wiedemann, Georg; Meisner, Christoph; Buchkremer, Gerhard; Frommann, Nicole; W�lwer, Wolfgang // European Archives of Psychiatry & Clinical Neuroscience;Nov2009 Supplement 2, Vol. 259, p149 

    Currently, there are no convincing treatment strategies for negative symptoms of schizophrenia. On this background, we are conducting the treatment of negative symptoms (TONES) study which addresses the question whether cognitive behavioural therapy (CBT) is efficacious for the reduction of...

  • History of alcohol abuse reduces response to antipsychotics in people with first episode psychosis. Green, A. I.; Tohen, M. F.; Hamer, R. M. // Evidence Based Mental Health;Aug2004, Vol. 7 Issue 3, p87 

    The article focuses on the prevalence of substance use disorder (SUD) among people with first episode psychosis, and their response to antipsychotic drugs. A randomized controlled trial was conducted and 262 people aged 16-40 years, with schizophrenia, schizophreniform and schizoaffective...

  • Family education for people with schizophrenia in Beijing, China. Zheng Li; Arthur, David // British Journal of Psychiatry;Oct2005, Vol. 187, p339 

    Background Much of China lacks well-developed services for people with schizophrenia and their families, and most of the existing services focus on hospitals. There is a need for culturally sensitive family treatments offered by nurses. Aims To conduct a longitudinal experimental study examining...

  • Interpretacja ustÄ™powania omamów sÅ‚uchowych przez chorego z przewlekÅ‚Ä… schizofreniÄ… - opis przypadku. Murawiec, Slawomir; Krzystoszek, Bogdan // Psychiatria Polska;2009, Vol. 43 Issue 2, p203 

    Aim. The aim of this case description is the analysis of psychotic symptoms resolution in the context of theory of psychosis as a state of aberrant salience. According to that theory both formation and treatment of psychotic symptoms can be seen in two interconnected dimensions: neurobiological...

  • Consistency of symptomatic dimensions of schizophrenia in a 12 year follow-up study. Cechnicki, Andrzej; Cichocki, Łukasz; Franczyk-Glita, Joanna // Archives of Psychiatry & Psychotherapy;Dec2010, Vol. 12 Issue 4, p29 

    Aim. The aim of the study was to identify syndromes measured by the BPRS -- E scale and to analyse changes in their consistency over the course of a 12 years prospective study. Material/method. A group of 80 patients with diagnosis of schizophrenia was followed up in 1, 3, 7 and 12 years after...

  • Ziprasidone good value for schizophrenia exacerbations.  // PharmacoEconomics & Outcomes News;8/25/2007, Issue 535, p1 

    The article focuses on an economic subanalysis of the Spanish ziprasidone vs haloperidol in sequential IM/Oral (ZIMO) treatment for schizophrenia exacerbations, conducted from a hospital perspective. The analysis included patients from the ZIMO database who had received sequential therapy with...

  • Employment Outcomes in a Randomized Trial of Second-Generation Antipsychotics and Perphenazine in the Treatment of Individuals with Schizophrenia. Resnick, Sandra G.; Rosenheck, Robert A.; Canive, Jose M.; De Souza, Cyril; Stroup, T. Scott; McEvoy, Joseph; Davis, Sonia; Keefe, Richard S. E.; Swartz, Marvin; Lieberman, Jeffrey // Journal of Behavioral Health Services & Research;Apr2008, Vol. 35 Issue 2, p215 

    Employment has been increasingly recognized as an important goal for individuals with schizophrenia. Previous research has shown mixed results on the relationship of specific antipsychotic medications to employment outcomes, with some studies finding greater benefits for second-generation...

  • Predictors of Remission and Recovery in a First-Episode Schizophrenia Spectrum Disorder Sample: 2-Year Follow-Up of the OPUS Trial. Petersen, Lone; Thorup, Anne; Øqhlenschlæger, Johan; Christensen, Torben Øqstergaard; Jeppesen, Pia; Krarup, Gertrud; Jørrgensen, Per; Mortensen, Erik Lykke; Nordentoft, Merete // Canadian Journal of Psychiatry;Oct2008, Vol. 53 Issue 10, p660 

    Objective: To examine the frequency and predictors of good outcome for patients with first-episode schizophrenia spectrum disorder (SSD). Method: We conducted a 2-year follow-up of a cohort of patients (n = 547) with first-episode SSD. We evaluated the patients on demographic variables,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics