The efficacy and safety of intensive statin therapy: a meta-analysis of randomized trials

Josan, Kiranbir; Majumdar, Sumit R.; McAlister, Finlay A.
February 2008
CMAJ: Canadian Medical Association Journal;2/26/2008, Vol. 178 Issue 5, p576
Academic Journal
The article investigates the efficacy and safety of different intensities of statin therapy in adults with coronary artery disease, using data from electronic databases, like MEDLINE, EMBASE and Web of Science. Findings reveal that intensive statin regimens lessen the patients' low-density lipoprotein level and reduces risk for myocardial infarction and stroke as well as patients' all-cause mortality, compared to lower intensity regimens. Results suggest that more intensive statin regimens should be used in patient with established coronary artery disease.


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