Hookworm Vaccines

Diemert, David J.; Bethony, Jeffrey M.; Hotez, Peter J.
January 2008
Clinical Infectious Diseases;1/15/2008, Vol. 46 Issue 2, p282
Academic Journal
Hookworm infection caused by the soil-transmitted nematodes Necator americanus and Ancylostoma duodenale is one of the most common parasitic infections worldwide. Although not directly responsible for substantial mortality, it' causes significant morbidity in the form of chronic anemia and protein malnutrition. Current global control efforts based on periodic mass anthelmintic administration are unsustainable, and new control strategies must be developed. This review describes progress in the development of vaccines against hookworm infection, including the preclinical and initial clinical testing of the N. americanus Ancylostoma Secreted Protein-2 Hookworm Vaccine. Plans call for eventual development of a vaccine that will combine at least 2 hookworm antigens—one targeting the larval stage of the life cycle and another targeting the adult worm living in the gastrointestinal tract.


Related Articles

  • hookworm infestation. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p385 

    An encyclopedia entry for the term "hookworm infestation" is presented. It refers to an infestation of the small intestine by bloodsucking worms of the Necator americanus or Ancylostoma duodenale species. This kind of infestation usually occurs in the tropics, especially in areas where...

  • X-ray structures of Na-GST-1 and Na-GST-2 two glutathione s-transferase from the human hookworm Necator americanus. Asojo, Oluwatoyin A.; Homma, Kohei; Sedlacek, Meghan; Ngamelue, Michelle; Goud, Gaddam N.; Zhan, Bin; Deumic, Vehid; Asojo, Oluyomi; Hotez, Peter J. // BMC Structural Biology;2007, Vol. 7, p1 

    Background: Human hookworm infection is a major cause of anemia and malnutrition of adults and children in the developing world. As part of on-going efforts to control hookworm infection, The Human Hookworm Vaccine Initiative has identified candidate vaccine antigens from the infective L3 larval...

  • HOOKWORM DISEASE. Stiles, C. H. Wardell; Altman, W. L. // Public Health Reports;Jan2006 Supplement 1, Vol. 121, p59 

    Discusses the results of a study on the presence of Necator americanus and Ancylostoma duodenale in hookworm infection and its treatment conducted in the U.S. Number of male and female hookworms discovered in cases of Ancylostoma duodenale; Effect of thymol treatment on hookworm infection;...

  • Identification of Ancylostoma ceylanicum in children from a tribal community in Tamil Nadu, India using a semi-nested PCR-RFLP tool. Geldhof, Peter; Vercruysse, Jozef; Levecke, Bruno; George, Santosh; Kaliappan, Saravanakumar Puthupalayam; Kattula, Deepthi; Roy, Sheela; Kang, Gagandeep // Transactions of the Royal Society of Tropical Medicine & Hygiene;Apr2015, Vol. 109 Issue 4, p283 

    Background: It is generally assumed that hookworm infections in humans are caused by Necator americanus and Ancylostoma duodenale. However, previous studies have also reported the presence of the animal hookworm A. ceylanicum in human stools. Methods: We determined hookworm infections in...

  • Relative Prevalence of the Human Hookworm Species, Necator americanus and Ancylostoma duodenale in Jos-North Local Government Area of Plateau State. Bala, A. Y. // Research Journal of Parasitology;2010, Vol. 5 Issue 1, p18 

    A study was conducted to determine the relative prevalence of the two species of hookworms (Necator americanus and Ancylostoma doudenale) in 144 hookworm-positive stool samples from 2,800 school children atteding 7 primary schools in Jos-North Local Government Area of Plateau State. Hookworm...

  • Discrimination of Gastrointestinal Nematode Eggs from Crude Fecal Egg Preparations by Inhibitor-Resistant Conventional and Real-Time PCR. Demeler, Janina; Ramünke, Sabrina; Wolken, Sonja; Ianiello, Davide; Rinaldi, Laura; Gahutu, Jean Bosco; Cringoli, Giuseppe; von Samson-Himmelstjerna, Georg; Krücken, Jürgen // PLoS ONE;Apr2013, Vol. 8 Issue 4, p1 

    Diagnosis of gastrointestinal nematodes relies predominantly on coproscopic methods such as flotation, Kato-Katz, McMaster or FLOTAC. Although FLOTAC allows accurate quantification, many nematode eggs can only be differentiated to genus or family level. Several molecular diagnostic tools...

  • Molecular Detection of Ancylostoma duodenale, Ancylostoma ceylanicum, and Necator americanus in Humans in Northeastern and Southern Thailand. Issarapong Phosuk; Pewpan M. Intapan; Tongjit Thanchomnang; Oranuch Sanpool; Penchom Janwan; Porntip Laummaunwai; Witthaya Aamnart; Nimit Morakote; Wanchai Maleewong // Korean Journal of Parasitology;Dec2013, Vol. 51 Issue 6, p747 

    The 2 principal species of hookworms infecting humans are Necator americanus and Ancylostoma duodenale. Case studies on zoonotic hookworm infections with Ancylostoma ceylanicum and/or Ancylostoma caninum are known mainly from Asian countries. Of these 2 zoonotic species, only A. ceylanicum can...

  • Understanding Heterogeneity in the Impact of National Neglected Tropical Disease Control Programmes: Evidence from School-Based Deworming in Kenya. Nikolay, Birgit; Mwandawiro, Charles S.; Kihara, Jimmy H.; Okoyo, Collins; Cano, Jorge; Mwanje, Mariam T.; Sultani, Hadley; Alusala, Dorcas; Turner, Hugo C.; Teti, Caroline; Garn, Josh; Freeman, Matthew C.; Allen, Elizabeth; Anderson, Roy M.; Pullan, Rachel L.; Njenga, Sammy M.; Brooker, Simon J. // PLoS Neglected Tropical Diseases;09/30/2015, Vol. 9 Issue 10, p1 

    Background: The implementation of soil-transmitted helminth (STH) treatment programmes occurs in varied environmental, social and economic contexts. Programme impact will be influenced by factors that affect the reduction in the prevalence and intensity of infections following treatment, as...

  • Real-time PCR Demonstrates Ancylostoma duodenale Is a Key Factor in the Etiology of Severe Anemia and Iron Deficiency in Malawian Pre-school Children. Jonker, Femkje A. M.; Calis, Job C. J.; Phiri, Kamija; Brienen, Eric A. T.; Khoffi, Harriet; Brabin, Bernard J.; Verweij, Jaco J.; Hensbroek, Michael Boele Van; Lieshout, Lisette Van // PLoS Neglected Tropical Diseases;Mar2012, Vol. 6 Issue 3, p1 

    Background: Hookworm infections are an important cause of (severe) anemia and iron deficiency in children in the tropics. Type of hookworm species (Ancylostoma duodenale or Necator americanus) and infection load are considered associated with disease burden, although these parameters are rarely...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics