TITLE

Outcome Assessment in Clinical Trials of Fracture-Healing

AUTHOR(S)
Morshed, Saam; Corrales, Luis; Genant, Harry; Miclau, III, Theodore
PUB. DATE
February 2008
SOURCE
Journal of Bone & Joint Surgery, American Volume;Feb2008 Supplement 1, Vol. 90-A, p62
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Although there are numerous methods for defining fracture-healing in clinical studies, no consensus exists regarding the most valid and reliable manner for assessing union or for determining which outcomes are most important. This article summarizes and describes methods for the clinical assessment of fracture-healing and reports results from a systematic review of prevalent definitions currently used in published clinical studies. Conventional radiography and ad hoc clinical definitions continue to be the most commonly used means of assessing fracture-healing in clinical studies. Investigators must improve upon and apply more rigorous outcome assessment in clinical trials, emphasize patient-important outcomes, and report factors that may bias estimated effects.
ACCESSION #
29419484

 

Related Articles

  • Stimulation of Fracture-Healing with Systemic Intermittent Parathyroid Hormone Treatment. Barnes, George L.; Kakar, Sanjeev; Vora, Siddarth; Morgan, Elise F.; Gerstenfeld, Louis C.; Einhorn, Thomas A. // Journal of Bone & Joint Surgery, American Volume;Feb2008 Supplement 1, Vol. 90-A, p120 

    Over the past several years, there has been an increasing interest in the biology of bone repair and potential technologies for enhancing fracture-healing. Part of this interest is derived from the growing age of the population and the recognition that increased age carries an increased risk of...

  • Selection and Development of Preclinical Models in Fracture-Healing Research. O'Loughlin, Padhraig F.; Morr, Simon; Bogunovic, Ljiljana; Kim, Abraham D.; Park, Brian; Lane, Joseph M. // Journal of Bone & Joint Surgery, American Volume;Feb2008 Supplement 1, Vol. 90-A, p79 

    Animal fracture models have been extensively applied to preclinical research as a platform to identify and characterize normal and abnormal physiological processes and to develop specific maneuvers that alter the biology and biomechanics being examined. The choice of animal model employed in a...

  • Bone Builders. Grose, Thomas K. // ASEE Prism;Apr2009, Vol. 18 Issue 8, p16 

    The article provides information on regarding the biomedical development of ways for bone regeneration. It states that a fracture putty is being developed at the University of Texas Science Center in Houston to speed up the bone development of patients who suffered bone fracture made by bombs....

  • Angiotensin Converting Enzyme Inhibition: Therapeutic Implications in Fracture Healing. Medhi, Bikash; Prakash, Ajay; Kaur, Sharonjeet; Bhagwat, Kishan; Chaudhary, S.; Goni, Vijay // JK Science;Apr-Jun2011, Vol. 13 Issue 2, p107 

    The article discusses the therapeutic implications of Angoitensin Converting Enzyme (ACE) inhibition in fracture healing. It talks about the capacity of tissue renin angiotensin aldosterone system (RAAS) for both the local generation and action of Angiotensin-II (Ang II). It notes that ACE leads...

  • Upper and Lower Limb Reconstruction Following Trauma. Jordan, Daniel J.; Hindocha, Sandip // Open Orthopaedics Journal;2014 Supplement, Vol. 8, p397 

    An introduction to the journal is presented in which the editor discusses various reports within the issue on topics including common techniques in open fracture management, pilon fracture treatment, and deficiency of soft tissue.

  • Critical Analysis of the Evidence for Current Technologies in Bone-Healing and Repair. Novicoff, Wendy M.; Manaswi, Abhijit; Hogan, MaCalus V.; Brubaker, Shawri M.; Mihalko, William M.; Saleh, Khaled J. // Journal of Bone & Joint Surgery, American Volume;Feb2008 Supplement 1, Vol. 90-A, p85 

    Substances that enhance fracture-healing and bone regeneration have valuable clinical application and merit future research. Advances in these technologies will enhance our ability to heal fractures in a more effective and expedient manner. This review provides a brief description of the...

  • Fracture Repair: Successful Advances, Persistent Problems, and the Psychological Burden of Trauma. Starr, Adam J. // Journal of Bone & Joint Surgery, American Volume;Feb2008 Supplement 1, Vol. 90-A, p132 

    This article is intended to deliver three messages. First, minimally invasive methods of fracture repair are successful; when coupled with advances in implant design, these techniques yield higher union rates with fewer complications than prior methods of direct open fracture repair. Fracture...

  • The Emperor's new vertebroplasty?  // Clinical Cardiology Alert;Oct2009 Clinical Briefs, p20 

    The article discusses research on vertebroplasty. It references a study by R. Buchbinder and colleagues, published in the 2009 issue of the "New England Journal of Medicine." The study examined the use of vertebroplasty in 78 patients with painful osteoporotic fracture. It found that...

  • AOA initiative guides physicians, hospitals in bone health education and treatment. Rapp, Susan M. // Orthopedics Today;Mar2010, Vol. 30 Issue 3, p22 

    The article focuses on the Own the Bone quality improvement initiative launched by the American Orthopaedic Association to guide hospitals and practitioners in managing bone health and fragility fractures.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics