Recombinant Human Platelet-Derived Growth Factor: Biology and Clinical Applications

Hollinger, Jeffrey O.; Hart, Charles E.; Hirsch, Steven N.; Lynch, Samuel; Friedlaender, Gary E.
February 2008
Journal of Bone & Joint Surgery, American Volume;Feb2008 Supplement 1, Vol. 90-A, p48
Academic Journal
The abilities of bone to remodel, fractures to repair, and bone grafts to incorporate are all fundamental reflections of the bone remodeling cycle. This process is characterized by the recruitment and differentiation of osteoblastic and osteoclastic cell populations, whose cellular activities are coordinated and regulated by an elaborate system of growth factors and cytokines. One of the crucial biological factors responsible for reparative osseous activity is platelet-derived growth factor (PDGF). The potent stimulatory effects of PDGF as a chemoattractant and mitogen for mesenchymal cells (including osteogenic cells), along with its ability to promote angiogenesis, have been demonstrated in a variety of preclinical models predicting maxillofacial, spine and appendicular skeletal, and soft-tissue applications. The biological profile of PDGF, including its ability to recruit osteoprogenitor cells, makes it particularly suited to address the skeletal defects that are seen with comorbid conditions such as osteoporosis, diabetes, and the effects of smoking. The clinical success and safety that have been demonstrated with use of recombinant human PDGF (rhPDGF) in the repair of periodontal defects have led to U.S. Food and Drug Administration (FDA) approval of rhPDGF for this indication. Ongoing pilot and pivotal trials in the United States and internationally will continue to clarify the promising role of PDGF in the treatment of challenging skeletal disorders.


Related Articles

  • Remodeling capacity and functional outcome of palmarly versus dorsally displaced pediatric radius fractures in the distal one-third. Zimmermann, Robert; Gschwentner, Martin; Pechlaner, Sigurd; Gabl, Markus // Archives of Orthopaedic & Trauma Surgery;Feb2004, Vol. 124 Issue 1, p42 

    Introduction. The purpose of this retrospective study was to compare the remodeling capacity and functional outcome of palmarly and dorsally displaced pediatric radius fractures in the distal one-third. Materials and methods. Fifty-three children with a residual dorsal angulation of 15°...

  • Reviewer’s comment. Jeanneret, B. // European Spine Journal;Feb2000, Vol. 9 Issue 1, p60 

    The article informs about the anterior screw fixation technique of the dens, which has changed the treatment of dens fractures type II. Minerva-casts or halo- braces no longer are needed. This technique of direct anterior screw fixation of dens fractures, however, has shown to be very demanding...

  • Stimulation of Fracture-Healing with Systemic Intermittent Parathyroid Hormone Treatment. Barnes, George L.; Kakar, Sanjeev; Vora, Siddarth; Morgan, Elise F.; Gerstenfeld, Louis C.; Einhorn, Thomas A. // Journal of Bone & Joint Surgery, American Volume;Feb2008 Supplement 1, Vol. 90-A, p120 

    Over the past several years, there has been an increasing interest in the biology of bone repair and potential technologies for enhancing fracture-healing. Part of this interest is derived from the growing age of the population and the recognition that increased age carries an increased risk of...

  • Operative treatment of metacarpal and phalangeal fractures in athletes: early return to play. Kodama, Narihito; Takemura, Yoshinori; Ueba, Hiroaki; Imai, Shinji; Matsusue, Yoshitaka // Journal of Orthopaedic Science;Sep2014, Vol. 19 Issue 5, p729 

    Background: Evaluating the outcomes of operative treatment for metacarpal and phalangeal fractures in athletes returning early to play and discussing the more effective methods that permit rapid early return to athletic activity. Methods: We retrospectively identified a total of 105 metacarpal...

  • Important risk factors and attributable risk of vertebral fractures in the population-based Troms study. Waterloo, Svanhild; Nguyen, Tuan; Ahmed, Luai A.; Center, Jacqueline R.; Morseth, Bente; Nguyen, Nguyen D.; Eisman, John A.; Søgaard, Anne J.; Emaus, Nina // BMC Musculoskeletal Disorders;2012, Vol. 13 Issue 1, p163 

    Background: Vertebral fractures, the most common type of osteoporotic fractures, are associated with increased risk of subsequent fracture, morbidity, and mortality. The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk....

  • Outcome Assessment in Clinical Trials of Fracture-Healing. Morshed, Saam; Corrales, Luis; Genant, Harry; Miclau, III, Theodore // Journal of Bone & Joint Surgery, American Volume;Feb2008 Supplement 1, Vol. 90-A, p62 

    Although there are numerous methods for defining fracture-healing in clinical studies, no consensus exists regarding the most valid and reliable manner for assessing union or for determining which outcomes are most important. This article summarizes and describes methods for the clinical...

  • Critical Analysis of the Evidence for Current Technologies in Bone-Healing and Repair. Novicoff, Wendy M.; Manaswi, Abhijit; Hogan, MaCalus V.; Brubaker, Shawri M.; Mihalko, William M.; Saleh, Khaled J. // Journal of Bone & Joint Surgery, American Volume;Feb2008 Supplement 1, Vol. 90-A, p85 

    Substances that enhance fracture-healing and bone regeneration have valuable clinical application and merit future research. Advances in these technologies will enhance our ability to heal fractures in a more effective and expedient manner. This review provides a brief description of the...

  • Assessment of a newly designed dynamic condylar screw with an angle of 102° in the treatment of unstable intertrochanteric fractures. Othman, A.Y. // European Journal of Orthopaedic Surgery & Traumatology;Dec2004, Vol. 14 Issue 4, p225 

    The aim of the study was to examine the clinical outcome of fixing unstable intertrochanteric fractures using a newly designed 102° dynamic condylar screw (DCS). Twelve unstable low-energy intertrochanteric fractures were fixed using 102° DCS. Patient ages ranged from 79 to 92 years. The...

  • Comparative Study of the Treatment Outcomes of Osteoporotic Compression Fractures without Neurologic Injury Using a Rigid Brace, a Soft Brace, and No Brace. Ho-Joong Kim; Je-Min Yi; Hyeon-Guk Cho; Bong-Soon Chang; Choon-Ki Lee; Jee Hyoung Kim; Yeom, Jin S. // Journal of Bone & Joint Surgery, American Volume;12/3/2014, Vol. 96 Issue 23, p1959 

    Background: The efficacy of brace application for the treatment of osteoporotic compression fractures remains unclear. The purpose of this study was to compare the treatment outcomes in patients with osteoporotic compression fractures with regard to whether the patients had no braces, rigid...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics