TITLE

Hepatoprotective Effect of Methanolic Leaves Extracts of Tylophora asthmatica Against Paracetamol-Induced Liver Damage in Rats

AUTHOR(S)
Malathi, R.; Gomez, M. Patrick
PUB. DATE
November 2007
SOURCE
Journal of Pharmacology & Toxicology;2008, Vol. 2 Issue 8, p737
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of the present study was to evaluate the hepatoprotective and antioxidant properties of methanolic leaves extracts of Tylophora asthmatica (META) on paracetamol-induced (1 g kg-1 body weight, i.p.,) hepatotoxicity in wistar strain of rats. The extract produced significant hepatoprotective effects as evidenced by decreased (p< 0.05) serum enzyme activities, ALT, AST, ALP, LDH and serum bilirubin (200 mg kg-1 body weight orally for 21 days) compared with control group. For antioxidant activity, META exhibited significant (p< 0.05) hepatoprotective effect by increasing the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and reducing lipid peroxidation (LPO). These results suggest that META may have hepatoprotective potential, probably by its antioxidant properties on hepatocytes and also support the use of the plant as a hepatoprotective agent.
ACCESSION #
29414063

 

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