TITLE

Association of MTRR 66A>G Polymorphism With Superoxide Dismutase and Disease Activity in Patients With Crohn's Disease

AUTHOR(S)
Peyrin-Biroulet, Laurent; Guéant-Rodriguez, Rosa-Maria; Chen, Min; Bronowicki, Jean-Pierre; Bigard, Marc-Andr; Guéant, Jean-Louis
PUB. DATE
February 2008
SOURCE
American Journal of Gastroenterology;Feb2008, Vol. 103 Issue 2, p399
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES: The aim of this study was to evaluate the association of nutritional (folate, vitamin B12) and genetic ( MTHFR, MTR, MTRR, TCN) determinants of homocysteine metabolism and of superoxide dismutase with Crohn's disease (CD). METHODS: One hundred forty patients with CD were compared with 248 matched healthy controls. RESULTS: Plasma homocysteine levels were higher in CD patients than controls (11.8 vs 10.4 μmol/L, P= 0.0004). Vitamin B12 and folate levels were lower in CD subjects compared to controls (207 vs 255 pmol/L, P= 0.0082, and 8.6 vs 11 nmol/L, P= 0036, respectively). Patients with a personal history of ileal resection, ileitis, or colectomy had significantly lower vitamin B12 levels. In multivariate analysis, vitamin B12 and MTHFR 677 TT carriers were the two significant independent factors of plasma homocysteine >15 μmol/L in CD patients ( P= 0.0187 and 0.0048, respectively). The significant association between homocysteine and vitamin B12 levels remained significant only in patients with the highest superoxide dismutase values ( P < 0.0001). The MTRR AA genotype was a significant independent predictor of CD risk (odds ratio 3.7, 95% CI 1.218–11.649, P= 0.0213). The level of superoxide dismutase was significantly higher ( P= 0.0143) and was correlated with Crohn's Disease Activity Index (CDAI) scores (P for trend = 0.0276) in patients carrying MTRR AA genotype. CONCLUSIONS: Vitamin B12 and MTHFR 677 TT genotype are the main determinants of hyperhomocysteinemia in CD patients. The association of MTRR 66A>G polymorphism with oxidant stress and disease activity provides rationale for screening vitamin deficiencies in these patients.
ACCESSION #
29383677

 

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