Poliwczak, Adam Rafał; Sławek, Dariusz; Bała, Agnieszka
December 2007
Problemy Terapii Monitorowanej;dec2007, Vol. 18 Issue 4, p255
Academic Journal
Stable angina is one of the most often occurred disease in the present world. Many studies indicate, that there is a relationship between elevated heart rate and increased risk of cardiovascular events. The treatment of stable angina is leaning on many methods including pharmacological treatment and revascularisation treatments. One of the newest medicines applied in the treatment of coronary heart disease is ivabradine. It is a selective sinus node If channel inhibitor. Studies showed, that ivabradine reduces heart rate without affecting cardiac systolic function and function of peripheral vessels. Moreover previous studies showed that ivabradine prevents myocardial ischemia so same effectively, as beta-blockers and calcium channel blockers without their adverse side effects. At present studies are checked the possibilities of applying it patients with acute coronary syndroms, which intolerate beta-blockers and in treatment patients with hard compromised left ventricular function in association with vasoactive and inotropic agents. These clinical trials are underway, and maybe they will help to evaluate fully the therapeutic potential of If inhibition in patients with coronary artery disease and another diseasey.


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