Correlates of HCV seropositivity among familial contacts of HCV positive patients

la Torre, Giuseppe; Miele, Luca; Mannocci, Alice; Chiaradia, Giacomina; Berloco, Filippo; Gabrieli, Maria L.; Gasbarrini, Giovanni; Ficarra, Maria Giovanna; Matera, Antonio; Ricciardi, Gualtiero; Grieco, Antonio
January 2006
BMC Public Health;2006, Vol. 6 Issue 1, p237
Academic Journal
Background: Determinants of intrafamilial HCV transmission are still being debated. The aim of this study is to investigate the correlates of HCV seropositivity among familial contacts of HCV positive patients in Italy. Methods: A cross-sectional study was conducted with 175 HCV positive patients (index cases), recruited from Policlinico Gemelli in Rome as well as other hospitals in Central Italy between 1995 and 2000 (40% female, mean age 57 ± 15.2 years), and 259 familial contacts. Differences in proportions of qualitative variables were tested with non-parametric tests (χ2, Yates correction, Fisher exact test), and a p value < 0.05 was considered significant. A multivariate analysis was conducted using logistic regression in order to verify which variables statistically have an influence on HCV positivity in contact individuals. Results: Seropositivity for HCV was found in 8.9% of the contacts. From the univariate analysis, risk factors significantly associated to HCV positivity in the contacts were: intravenous drug addiction (p = 0.004) and intercourse with drug addicts (p = 0.005). The only variables associated significantly and independently to HCV seropositivity in patients' contacts were intercourse with drug addicts (OR = 19.28; 95% CI: 2.01 - 184.94), the retirement status from work (OR = 3.76; 95% CI: 1.17 - 11.98), the time of the relationship (OR = 1.06; 95% CI: 1.00 - 1.11) and tattoos (OR = 7.68; 95% CI: 1.00 - 60.20). Conclusion: The present study confirms that having intercourse with a drug addict is the most significant risk factor for intrafamilial HCV transmission. The association with retirement status from work could be related to both a long-term relationship with an index case and past exposure to common risk factors.


Related Articles

  • Behavioural predictors of subsequent hepatitis C diagnosis in a UK clinic sample of HIV positive men who have sex with men. Turner, J. M.; Rider, A. T.; Imrie, J.; Copas, A. J.; Edwards, S. G.; Dodds, J. P.; Stephenson, J. M. // Sexually Transmitted Infections;Aug2006, Vol. 82 Issue 4, p298 

    Objective: To explore the associations between self reported high risk sexual behaviours and subsequent diagnosis with hepatitis C virus (HCV) infection. Methods: The Sex, Health and Anti-Retrovirals Project (SHARP) was a cross sectional study of sexual behaviour in HIV positive, men who have...

  • Factors Associated with Oropharyngeal Human Immunodeficiency Virus Shedding. Zuckerman, Richard A.; Whittington, William L.H.; Celum, Connie L.; Collis, Tarquin; Lucchetti, Aldo; Sanchez, Jorge L.; Hughes, James P.; Sanchez, Jose L.; Coombs, Robert W. // Journal of Infectious Diseases;7/1/2003, Vol. 188 Issue 1, p142 

    Orogenital transmission of human immunodeficiency virus (HIV) is considered to be inefficient, and infectious HIV is rarely detected in saliva. To evaluate the posterior oropharynx as a source of HIV shedding, we studied 64 HIV-infected men who have sex with men in Seattle, Washington, and Lima,...

  • Heterosexual transmission of hepatitis C virus in family groups without risk factors. Peano, G.M.; Fenoglio, L.M.; Menardi, G.; Balbo, R.; Marenchino, D.; Fenoglio, S. // BMJ: British Medical Journal (International Edition);12/12/92, Vol. 305 Issue 6867, p1473 

    Examines the risk factors of hepatitis C virus (HCV) transmission. Transmission of HCV by heterosexual intercourse; Effect of anti-HCV positive on the liver condition; Use of polymerase chain reaction.

  • THE BOYZ DOC. WATERS, LAURA // BOYZ;7/23/2015, Issue 1246, p44 

    The article provides an answer to a question on the effects of having sexual intercourse with a person infected with hepatitis C.

  • The Asymptomatic HBs-Ag Carrier: Auto- and Heterologous Perils. Steigmann, Frederick; Dourdourekas, Demetrios; Canlas, Noel // American Journal of Gastroenterology;Jun1976, Vol. 65 Issue 6, p512 

    The asymptomatic carrier--usually discovered on offering to be a blood donor--presents a complex health problem which to date has received only "guarded" attention. These carriers may be dangerous, because they can transmit the HBs-Ag not only by parenteral but also by "nonparenteral" means, due...

  • Increase in HCV Incidence among Men Who Have Sex with Men in Amsterdam Most Likely Caused by Sexual Transmission. van de Laar, Thijs J. W.; van der Bij, Akke K.; Prins, Maria; Bruisten, Sylvia M.; Brinkman, Kees; Ruys, Thomas A.; van der Meer, Jan T. M.; de Vries, Henry J. C.; Mulder, Jan-Willem; van Agtmael, Michiel; Jurriaans, Suzanne; Wolthers, Katja C.; Coutinho, Roel A. // Journal of Infectious Diseases;7/15/2007, Vol. 196 Issue 2, p230 

    We retrospectively screened 1836 men who have sex with men (MSM) participating in the Amsterdam Cohort Studies (1984-2003) for hepatitis C virus (HCV) antibodies. HCV incidence was 0.18/100 person-years (PY) in human immunodeficiency virus (HIV)-positive MSM (8/4408 PY [95% confidence interval...

  • HCV TRANSMISSION BETWEEN SERODISCORDANT COUPLES THROUGH SEXUAL ROUTE. Ali Khan, Rao Saad; Khalid, Shahid Raza; Naseer, Muhammad; Mirza, Rameesa // Pakistan Armed Forces Medical Journal;6/30/2014, Vol. 64 Issue 2, p265 

    Objective: To determine the rate of transmission of HCV between spouses through sexual route. Study Design: Descriptive study. Place and Duration of Study: This study was carried out at Military Hospital, Rawalpindi, Pakistan. It was conducted over a period of 4 years from June 2009 to June...

  • Sex, Drugs, and Hepatitis C Virus. Hahn, Judith A. // Journal of Infectious Diseases;6/1/2007, Vol. 195 Issue 11, p1556 

    The article presents the author's views related to the transmission of Hepatitis C Virus (HCV) with reference to sexual intercourse and drug abuse. The author comments that the conflicting data about sexual transmission given in an article on transmission of Hepatitis C Virus published in the...

  • Factor Differentials in contraceptive use and demographic profile among females who had their first coital activity at most 16 years versus those at 16+ years old in a developing nation. Bourne, Paul A. // International Journal of Collaborative Research on Internal Medi;Nov2010, Vol. 2 Issue 11, p377 

    Background: Previous studies have examined age at first sexual intercourse and factors which determine contraceptive use, but none have explored factors which determined method of contraception use between females whose first coital activity began at 16+ years and those who started < 16 years...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics