Male gonadal dose of ionizing radiation delivered during X-ray examinations and monthly probability of pregnancy: a population-based retrospective study

Sinno-Tellier, Sandra; Bouyer, Jean; Ducot, Béatrice; Geoffroy-Perez, Beatrice; Spira, Alfred; Slama, Remy
January 2006
BMC Public Health;2006, Vol. 6 Issue 1, p55
Academic Journal
Background: Male gonadal exposure to ionizing radiation may disrupt spermatogenesis, but its influence on the fecundity of couples has been rarely studied. We aimed to characterize the influence of male gonadal dose of ionizing radiation delivered during radiodiagnostic on the monthly probability of pregnancy. Methods: We recruited a random sample of women who retrospectively described 1110 periods of unprotected intercourse beginning between 1985 and 1999 and leading either to a live birth or to no pregnancy; their duration was censored after 13 months. The male partner answered a telephone questionnaire on radiodiagnostic examinations. We assigned a mean gonadal dose to each type of radiodiagnostic examination. We defined male dose for each period of unprotected intercourse as the sum of the gonadal doses of the X-ray examinations experienced between 18 years of age and the date of discontinuation of contraception. Time to pregnancy was analysed using a discrete Cox model with random effect allowing to estimate hazard ratios of pregnancy. Results: After adjustment for female factors likely to influence fecundity, there was no evidence of an association between male dose and the probability of pregnancy (test of homogeneity, p = 0.55). When compared to couples with a male gonadal dose between 0.01 and 0.20 milligrays (n = 321 periods of unprotected intercourse), couples with a gonadal dose above 10 milligrays had a hazard ratio of pregnancy of 1.44 (95% confidence interval, 0.73-2.86, n = 31). Conclusion: Our study provides no evidence of a long-term detrimental effect of male gonadal dose of ionizing radiation delivered during radiodiagnostic on the monthly probability of pregnancy during the year following discontinuation of contraceptive use. Classification errors due to the retrospective assessment of male gonadal exposure may have limited the statistical power of our study.


Related Articles

  • Why male fertility is about more than just sperm count. Ford, Chris; Gordon, Uma // Pulse;1/26/2004, Vol. 64 Issue 4, p50 

    Focuses on male fertility. Mention of the effectiveness of assisted reproduction in the form of intracytoplasmic sperm injection; Account of lifestyle factors that affect male sub-fertility; Information regarding optimal spermatogenesis.

  • Conference Abstracts . . . February 8, 2010.  // Fertility Weekly;2/8/2010, p12 

    The article presents abstracts on fertility and human development topics which include the empirical oral antibiotic and anti-inflammatory treatment of prostate and seminal vesicles, the exploratory study which assess the effect of daily ejaculation, and the new method in evaluating sperm...

  • Aging, Mitochondria and Male Reproductive Function. Amaral, Sandra; Ramalho-Santos, João // Current Aging Science;Dec2009, Vol. 2 Issue 3, p165 

    The rise in life expectancy over the last century, together with higher maternal and paternal ages and have highlighted the issue of reduced fertility with advancing age. Aging of the male reproductive system is incited by multi-factorial changes at molecular, cellular and regulatory levels, and...

  • Persistent Mullerian Duct Syndrome and Hernia Uteri Inguinalis in a Male With Normal Fertility. Nandedkar, Shirish S.; Mahato, Niladri Kumar; Bhandari, Bhupendra // UroToday International Journal;2010, Vol. 3 Issue 3, p1 

    Nonregression of Mullerian ducts in individuals who are phenotypically male with an XY genotype is a rare occurrence. This condition usually presents as unilateral or bilateral undescended or partially descended testes. Additionally, it is often associated with inguinal swellings. These...

  • Reproductive biology of the endangered percid Zingel asper in captivity: a histological description of the male reproductive cycle. Chevalier, Christine; de Conto, Christine; Exbrayat, Jean-Marie // Folia Histochemica et Cytobiologica;2011, Vol. 49 Issue 3, p486 

    Abstract: The endemic Rhodanian percid Zingel asper (Linnaeus, 1758), is usually found throughout the Rhone basin, but this fish is now in sharp decline. Understanding its reproductive physiology is important so as to be able to artificially control its reproduction with a view to re-introducing...

  • Cloacal Gland Size Significantly Alters Semen Production, Sperm Activities and Fertility in Different Lines of Japanese Quail (Coturnix coturnix japonica). Shit, N.; Singh, R. P.; Sastry, K. V. H.; Mohan, J.; Pandey, N.; Moudgal, R. P. // Asian Journal of Poultry Science;2010, Vol. 4 Issue 4, p190 

    No abstract available.

  • Isolation and characterization of novel testis-specific genes from mouse pachytene spermatocyte-enriched cDNA library. Ijiri, Takashi W.; Nagase, Takahiro; Matsuda, Yoichi // Reproductive Medicine & Biology;Dec2005, Vol. 4 Issue 4, p231 

    Background and Aims: Isolation and analysis of spermatogenesis-specific genes provide important information for elucidating the mechanisms of human infertility. The aim of the present study was to suggest an effective strategy for the comprehensive isolation of novel genes associated with...

  • Coordinated transcriptional regulation patterns associated with infertility phenotypes in men. Ellis, Peter J. I.; Furlong, Robert A.; Conner, Sarah J.; Kirkman-Brown, Jackson; Afnan, Masoud; Barratt, Christopher; Griffin, Darren K; Affara, Nabeel A. // Journal of Medical Genetics;Aug2007, Vol. 44 Issue 8, p498 

    Introduction: Microarray gene-expression profiling is a powerful tool for global analysis of the transcriptional consequences of disease phenotypes. Understanding the genetic correlates of particular pathological states is important for more accurate diagnosis and screening of patients, and thus...

  • Treating Azoospermia with ICSI Not Always Best Option.  // Fertility Weekly;3/14/2011, p2 

    The article presents a study conducted by Herman Tournaye in Belgium on surgical sperm recovery, the method for getting spermatozoa for intracytoplasmic sperm injection (ICSI). The study found that ICSI is the preferred treatment for all azoospermia cases, replacing the classic treatment methods...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics