The protocols for the 10/66 dementia research group population-based research programme

Prince, Martin; Ferri, Cleusa P.; Acosta, Daisy; Albanese, Emiliano; Arizaga, Raul; Dewey, Michael; Gavrilova, Svetlana I.; Guerra, Mariella; Yueqin Huang; Jacob, K. S.; Krishnamoorthy, E. S.; McKeigue, Paul; Rodriguez, Juan Llibre; Salas, Aquiles; Sosa, Ana Luisa; Sousa, Renata M. M.; Stewart, Robert; Uwakwe, Richard
January 2007
BMC Public Health;2007, Vol. 7 Issue 1, p165
Academic Journal
Background: Latin America, China and India are experiencing unprecedentedly rapid demographic ageing with an increasing number of people with dementia. The 10/66 Dementia Research Group's title refers to the 66% of people with dementia that live in developing countries and the less than one tenth of population-based research carried out in those settings. This paper describes the protocols for the 10/66 population-based and intervention studies that aim to redress this imbalance. Methods/design: Cross-sectional comprehensive one phase surveys have been conducted of all residents aged 65 and over of geographically defined catchment areas in ten low and middle income countries (India, China, Nigeria, Cuba, Dominican Republic, Brazil, Venezuela, Mexico, Peru and Argentina), with a sample size of between 1000 and 3000 (generally 2000). Each of the studies uses the same core minimum data set with cross-culturally validated assessments (dementia diagnosis and subtypes, mental disorders, physical health, anthropometry, demographics, extensive non communicable disease risk factor questionnaires, disability/functioning, health service utilisation, care arrangements and caregiver strain). Nested within the population based studies is a randomised controlled trial of a caregiver intervention for people with dementia and their families (ISRCTN41039907; ISRCTN41062011; ISRCTN95135433; ISRCTN66355402; ISRCTN93378627; ISRCTN94921815). A follow up of 2.5 to 3.5 years will be conducted in 7 countries (China, Cuba, Dominican Republic, Venezuela, Mexico, Peru and Argentina) to assess risk factors for incident dementia, stroke and all cause and cause-specific mortality; verbal autopsy will be used to identify causes of death. Discussion: The 10/66 DRG baseline population-based studies are nearly complete. The incidence phase will be completed in 2009. All investigators are committed to establish an anonymised file sharing archive with monitored public access. Our aim is to create an evidence base to empower advocacy, raise awareness about dementia, and ensure that the health and social care needs of older people are anticipated and met.


Related Articles

  • THE STAGE IS SET. Manthorpe, Jill; Iliffe, Steve // Community Care;3/6/2003, Issue 1462, p42 

    Reveals that the use of stages to describe the progress of dementia is helpful when identifying the support needs of people with the condition. Different meanings of stages in medical discussion; Stages of dementia.

  • Comprehensive Behavioral Testing in the R6/2 Mouse Model of Huntington's Disease Shows No Benefit from CoQ10 or Minocycline. Menalled, Liliana B.; Patry, Monica; Ragland, Natalie; Lowden, Phillip A. S.; Goodman, Jennifer; Minnich, Jennie; Zahasky, Benjamin; Park, Larry; Leeds, Janet; Howland, David; Signer, Ethan; Tobin, Allan J.; Brunner, Daniela // PLoS ONE;2010, Vol. 5 Issue 3, p1 

    Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington's disease have produced conflicting results regarding their efficacy in behavioral tests. Using our recently published best practices for husbandry and testing for mouse models of Huntington's disease,...

  • The Ekman 60 Faces Test as a diagnostic instrument in frontotemporal dementia. Diehl-Schmid, Janine; Pohl, Corina; Ruprecht, Carolin; Wagenpfeil, Stefan; Foerstl, Hans; Kurz, Alexander // Archives of Clinical Neuropsychology;May2007, Vol. 22 Issue 4, p459 

    Abstract: Frontotemporal dementia (FTD) is characterized by dramatic changes of personality and behaviour. Impaired ability of emotional processing could contribute to these symptoms, as it may lead to misinterpretation of emotional cues that would normally guide behaviour. The aim of the...

  • Dementia in Malta: new prevalence estimates and projected trends. Scerri, Anthony; Scerri, Charles // Malta Medical Journal;2012, Vol. 24 Issue 3, p21 

    Previous estimates have indicated that in 2005, there were 4,072 individuals with dementia (IWD) in the Maltese islands and that this number would almost double by the year 2050. These figures were based on the EURODEM project that analysed the results of a population-based systematic review of...

  • Dementia Is a Death Sentence. Wilke, Allan J. // Internal Medicine Alert;3/15/2008, Vol. 30 Issue 5, p34 

    The article presents a study based on Great Britain's Medical Research Council's Cognitive Function and Ageing Study (MRC CFAS) regarding people with dementia, which shows that there were 438 incident cases of dementia and 81% died that occurred at a median age of 90 for women and 87 for men.

  • Lipid Peroxidation and Antioxidant Enzyme Activities in Vascular and Alzheimer Dementias. Ãngela Casado; Mª Encarnación López-Fernández; Mª Concepción Casado; Rosario de La Torre // Neurochemical Research;Mar2008, Vol. 33 Issue 3, p450 

    Abstract  It has been reported that oxidative stress may play a role in the pathogenesis of dementia of the Alzheimer type (AD) and the cerebral ischemia which causes vascular dementia (VD). We measured malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT),...

  • Dementia.  // Current Medical Literature: Neurology;2008, Vol. 24 Issue 1, p12 

    Several abstracts of studies on dementia are presented including the link between smoking and risk of dementia and Alzheimer's disease, the necessity of a functional decline in the diagnosis of Alzheimer's disease, and the effects of cholinesterase inhibitors and memantine in vascular dementia.

  • Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease. Van Raamsdonk, Jeremy M.; Pearson, Jacqueline; Murphy, Zoe; Hayden, Michael R.; Leavitt, Blair R. // BMC Neuroscience;2006, Vol. 7, p80 

    Background: Huntington disease (HD) is an adult onset neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (htt) protein. Htt function is essential for embryonic survival as well as normal function during the postnatal period. In addition to having roles in...

  • Overcoming Educational Barriers for Advance Care Planning in Latinos with Video Images. Volandes, Angelo E.; Ariza, Miguel; Abbo, Elmer D.; Paasche-Orlow, Michael // Journal of Palliative Medicine;Jun2008, Vol. 11 Issue 5, p700 

    Background: Studies of end-of-life care have shown that Latino patients want more aggressive care compared to white patients. While this has been attributed to aspects of ethnicity, national origin, and religion, it is possible that limited education might obscure the true relationship between...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics