Diet induced weight loss accelerates onset of negative alliesthesia in obese women

Frankham, Patrick; Gosselin, Caroline; Cabanac, Michel
January 2005
BMC Public Health;2005, Vol. 5 Issue 1, p112
Academic Journal
Background: The physiological and behavioral responses to hypocaloric diet are to increase energy intake to defend a steady body weight. We utilized the method of "negative alliesthesia" for measuring the hedonic reponse to sweet stimulus before (Initial session) and 3 months after entering a weight loss program. The negative alliesthesia test is known by physiologists but few clinical data exist. It is based on the observation that repeated pleasant gustatory stimuli turn into unpleasantness in the process of alliesthesia. At first visit participants repeatedly ingested sweet stimuli until they found them unpleasant and rated quantitatively on a linear analogue scale their hedonic experience. This procedure was repeated every 3 min until participants felt displeasure to end the session. The same protocol was followed after three months of following a weight loss diet. Dieting energy intake was from 1400 - 2000 kcal/d for 8 wk. Energy composition was 50% carb:25% prot: 25% lipid. After 8 wk caloric intake increased by 50 kcal/wk, to reach daily intake of 1800 - 2400 kcal/d. Energy composition was 50% carb:22% prot: 27% lipid. We report results on the effect of slow weight loss on negative alliesthesia in ten obese female participants enrolled in a commercial diet program based on Canada's Food Guide (Mincavi®). Results: Results showed that diet lowered the mean BMI (Initial session 36.8 +/- 1.8 vs. 3 mo 34.9 +/- 1.8 kg/m2). At 3 mo the onset of negative alliesthesia, time to abandon experimental session, was shortened (Initial session 33 vs. 3 mo 24 min). The same trend was observed in the time to reach indifference (Initial session 21.9 +/- 3.8 vs. 3 mo 16.2 +/-2.4 min). There was no observed difference in maximum (Initial session +79.5 +/- 11.7; 3 mo +94.5 +/- 9.9 mm) and minimum (Initial session -90.0 +/- 14.4; 3 mo -106 +/- 11.1 mm) hedonic rating. Conclusion: Earlier onset of negative alliesthesia, as seen in our participants, is not consistent with previous hedonic studies that showed delayed or absent negative alliesthesia in participants when below their initial body weight. Therefore, it is hypothesized that the accelerated onset of negative alliesthesia observed in our obese participants after weight loss is suggestive of a lowered body weight set-point. Factors inherent to the weight loss diet studied here, such as mild energetic restriction, lowered palatability, and diet composition, may have played a role in this experimental outcome.


Related Articles

  • Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Laviano, A; Molfino, A; Lacaria, M T; Canelli, A; De Leo, S; Preziosa, I; Rossi Fanelli, F // European Journal of Clinical Nutrition;Nov2014, Vol. 68 Issue 11, p1264 

    Glutamine supplementation improves insulin sensitivity in critically ill patients, and prevents obesity in animals fed a high-fat diet. We hypothesized that glutamine supplementation favors weight loss in humans. Obese and overweight female patients (n=6) were enrolled in a pilot, cross-over...

  • Effect of an energy reduced high protein red meat diet on weight loss and metabolic parameters in obese women. Clifton, P. M.; Noakes, M.; Keogh, J.; Foster, P. // Asia Pacific Journal of Clinical Nutrition;2003 Supplement, Vol. 12, pS10 

    Aim - To determine the effects on weight loss, fat and lean body mass, metabolic parameters and markers of bone turnover of reduced energy intake with increased protein from red meat in overweight and obese women (BMI 27-40). Methods - Twelve week randomised parallel design of two 5600KJ diets:...

  • Atkins wins weight loss 'competition.'.  // Active Living;May2007, Vol. 16 Issue 3, p19 

    The article discusses research published in the "Journal of the American Medical Association," which showed that Atkins Diet works better than most diet strategies. The study involved overweight and obese U.S. women under Atkins diet. Women under other diets such as the Zone, the lifestyle,...

  • ZhorÅ¡ení indexu inzulinové rezistence po třímÄ›síčním užívání „spalovače tuků“.  // Medicina Sportiva Bohemica et Slovaca;2010, Vol. 19 Issue 4, p214 

    No abstract available.

  • A SOCIAL ECOLOGICAL APPROACH TO THE OBESITY EPIDEMIC. P�pin, V�ronique; McMahan, Shari; Swan, Pamela D. // American Journal of Health Studies;2004, Vol. 19 Issue 2, p122 

    The purpose of this preliminary study was to identify environmental factors that impact weight management in midlife women. A questionnaire was developed and distributed to women aged35-65. Forty middle-aged (47.4 � 6.6), Caucasian (82.5%) women returned completed questionnaires. Analyses...

  • Dose–response effect of walking exercise on weight loss. How much is enough? Bond Brill, J; Perry, A C; Parker, L; Robinson, A; Burnett, K // International Journal of Obesity & Related Metabolic Disorders;Nov2002, Vol. 26 Issue 11, p1484 

    OBJECTIVE:: Exercise is the cornerstone of behavioral weight loss programs. The total volume of exercise needed to both promote weight loss and elicit health benefits has not been sufficiently investigated. The aim of this study was to examine the effects of two different volumes of walking...

  • Relationship of a large weight loss to long-term weight change among young and middle-aged US women. Field, A E; Wing, R R; Manson, J E; Spiegelman, D L; Willett, W C // International Journal of Obesity & Related Metabolic Disorders;Aug2001, Vol. 25 Issue 8, p1113 

    OBJECTIVE: To assess the prevalence of clinically significant weight loss among women and whether this is associated with smaller long-term weight gains. DESIGN: Six-year follow-up of young and middle-aged women in the Nurses' Health Study II. SUBJECTS: A total of 47 515 women who did not report...

  • WINDOW FOR WEIGHT LOSS. STROTE, MARY ELLEN // Fit Pregnancy;Oct/Nov2013, Vol. 20 Issue 4, p36 

    The article reports that a research has found that the interval between pregnancies can be the best time for obese women to lose weight.

  • How useful is waist circumference for assessment of abdominal obesity in Korean pre-menopausal women during weight loss? Mi-Ja Hwang; Won-Suk Chung; Gallagher, Dympna; Deog-Yoon Kim; Hyun-Dae Shin; Mi-Yeon Song // Asia Pacific Journal of Clinical Nutrition;Jun2008, Vol. 17 Issue 2, p229 

    Asian women are known to have a larger amount of abdominal fat (AF) for the same level of BMI compared with Caucasian and African-American women. This study was aimed to determine whether waist circumference (WC) could be useful as an index of AF compared with AF measured by dual energy x-ray...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics