TITLE

A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; Expanding the use of Vi polysaccharide vaccine in Southeast China: A cluster-randomized trial

AUTHOR(S)
Jin Yang; Acosta, Camilo J.; Guo-ai Si; Jun Zeng; Cui-yun Li; Da-bin Liang; Ochiai, R. Leon; Page, Anne-Laure; Danovaro-Holliday, M. Carolina; Jie Zhang; Bao-de Zhou; He-zhuang Liao; Ming-liu Wang; Dong-mei Tan; Zhen-zhu Tang; Jian Gong; Jin-Kyung Park; Ali, Mohammad; Ivanoff, Bernard; Gui-chen Liang
PUB. DATE
January 2005
SOURCE
BMC Public Health;2005, Vol. 5, p49
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: One of the goals of this study was to learn the coverage, safety and logistics of a mass vaccination campaign against typhoid fever in children and adults using locally produced typhoid Vi polysaccharide (PS) and group A meningococcal PS vaccines in southern China. Methods: The vaccination campaign targeted 118,588 persons in Hechi, Guangxi Province, aged between 5 to 60 years, in 2003. The study area was divided into 107 geographic clusters, which were randomly allocated to receive one of the single-dose parenteral vaccines. All aspects regarding vaccination logistics, feasibility and safety were documented and systematically recorded. Results of the logistics, feasibility and safety are reported. Results: The campaign lasted 5 weeks and the overall vaccination coverage was 78%. On average, the 30 vaccine teams gave immunizations on 23 days. Vaccine rates were higher in those aged ≤ 15 years (90%) than in adolescents and young adults (70%). Planned mop-up activities increased the coverage by 17%. The overall vaccine wastage was 11%. The cold chain was maintained and documented. 66 individuals reported of adverse events out of all vaccinees, where fever (21%), malaise (19%) and local redness (19%) were the major symptoms; no life-threatening event occurred. Three needle-sharp events were reported. Conclusion: The mass immunization proved feasible and safe, and vaccine coverage was high. Emphasis should be placed on: injection safety measures, community involvement and incorporation of mop-up strategies into any vaccination campaign. School-based and all-age Vi mass immunizations programs are potentially important public health strategies for prevention of typhoid fever in high-risk populations in southern China.
ACCESSION #
29361811

 

Related Articles

  • Immunization Against Typhoid.  // Annals of Internal Medicine;Dec66, Vol. 65 Issue 6, p1300 

    Presents the recommendations of the Advisory Committee on Immunization Practices of the U.S. Public Health Service on immunization against typhoid. Status of typhoid vaccine; Dosage and schedule of administration; Alternative routes and dosages of booster immunization.

  • Typhoid Vaccination.  // Clinical Pediatrics;Jul1967, Vol. 6 Issue 7, p10A 

    The article discusses recommendations on immunization practices for typhoid vaccination. Routine typhoid immunization is not recommended in the United States. Selective immunization is indicated in the following situations: (1) Intimate exposure to a known typhoid carrier as would occur with...

  • TRAVEL ADVICE IMMUNISATIONS.  // GP: General Practitioner;2/18/2002, p84 

    Presents chart depicting on travel advice of immunization. Status of hepatitis A and typhoid vaccination in several countries; Diseases requiring vaccination; Vaccine courses and doses.

  • Travel Vaccines and Elderly Persons: Review of Vaccines Available in the United States. Leder, Karin; Weller, Peter F.; Wilson, Mary E. // Clinical Infectious Diseases;11/1/2001, Vol. 33 Issue 9, p1553 

    Provides information on several travel vaccines administered to elderly persons in the United States and the effect of age on their effectiveness. Indications for hepatitis A vaccines; Types of typhoid fever vaccine; Systemic and local reactions associated with yellow fever vaccines.

  • TIP OF THE MONTH: Typhoid.  // Pulse;5/17/2007, Vol. 67 Issue 19, p76 

    The article provides information on the 70 changes to typhoid recommendations in May 2007, following a review of data by Health Protection Scotland published on the UK Travax website. One alteration is that typhoid immunization is no longer recommended for most of the countries that previously...

  • The Use of Typhoid Vaccines in Asia: The DOMI Experience. Ochiai, R. Leon; Acosta, Camilo J.; Agtini, Magdarina; Bhattacharya, Sujit K.; Bhutta, Zulfiqar A.; Canh Gia Do; Baiqing Dong; Xinguang Chen; Stanton, Bonita; Kaljee, Linda; Nyamete, Andrew; Galindo, Claudia M.; von Seidlein, Lorenz; DeRoeck, Denise; Jodar, Luis; Clemens, John D. // Clinical Infectious Diseases;7/15/2007 Supplement, Vol. 45, pS34 

    Background. Two currently licensed typhoid vaccines have been evaluated in Asia, yet few Asian countries have considered including typhoid vaccines in their vaccination programs. The Diseases of the Most Impoverished (DOMI) Program was initiated to provide evidence to decide on the introduction...

  • TIP OF THE MONTH: Typhoid.  // Pulse;5/10/2007, Vol. 67 Issue 18, p77 

    The article reports on the changes to typhoid immunization recommendations by the Health Protection Scotland. The vaccination is no longer advisable for most of the countries that previously had an S for sometimes indication, including Europe, South America and the U.S. Furthermore, most central...

  • ACIP revises typhoid immunization recommendations.  // American Family Physician;3/1/1995, Vol. 51 Issue 4, p969 

    Presents the recommendations on typhoid immunization, as released by the Advisory Committee on Immunization Practices. Three types of typhoid vaccines; Use of the Vi capsular polysaccharide vaccine, which was approved by the Food and Drug Administration for the prevention of typhoid fever;...

  • Safety, Immunogenicity and Dose Ranging of a New Vi-CRM197 Conjugate Vaccine against Typhoid Fever: Randomized Clinical Testing in Healthy Adults. van Damme, Pierre; Kafeja, Froukje; Anemona, Alessandra; Basile, Venere; Hilbert, Anne Katrin; De Coster, Ilse; Rondini, Simona; Micoli, Francesca; Khan, Rana M. Qasim; Marchetti, Elisa; Di Cioccio, Vito; Saul, Allan; Martin, Laura B.; Podda, Audino // PLoS ONE;2011, Vol. 6 Issue 9, p1 

    Background: Typhoid fever causes more than 21 million cases of disease and 200,000 deaths yearly worldwide, with more than 90% of the disease burden being reported from Asia. Epidemiological data show high disease incidence in young children and suggest that immunization programs should target...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics