Allergic conditions and risk of hematological malignancies in adults: a cohort study

Söderberg, Karin C.; Hagmar, Lars; Schwartzbaum, Judith; Feychting, Maria
January 2004
BMC Public Health;2004, Vol. 4, p51
Academic Journal
Background: Two contradictory hypotheses have been proposed to explain the relationship between allergic conditions and malignancies, the immune surveillance hypothesis and the antigenic stimulation hypothesis. The former advocates that allergic conditions may be protective against development of cancer, whereas the latter proposes an increased risk. This relationship has been studied in several case-control studies, but only in a few cohort studies. Methods: The association between allergic conditions and risk of developing leukemia, Hodgkin's disease, non-Hodgkin's lymphoma and myeloma was investigated in a cohort of 16,539 Swedish twins born 1886-1925. Prospectively collected, self-reported information about allergic conditions such as asthma, hay fever or eczema was obtained through questionnaires administered in 1967. The cohort was followed 1969-99 and cancer incidence was ascertained from the Swedish Cancer Registry. Results: Hives and asthma tended to increase the risk of leukemia (relative risk [RR] = 2.1, 95% Confidence Interval [CI] 1.0-4.5 and RR = 1.6, 95% CI 0.8-3.5, respectively). There was also an indication of an increased risk of non-Hodgkin's lymphoma associated with eczema during childhood (RR = 2.3, 95% CI 1.0-5.3). Conclusion: In contrast to most previous studies, our results do not indicate a protective effect of allergic conditions on the risk of developing hematological malignancies. Rather, they suggest that allergic conditions might increase the risk of some hematological malignancies.


Related Articles

  • An epidemiological study of cancer in adult twins born in Norway 1905–1945. Iversen, T; Tretli, S; Kringlen, E // British Journal of Cancer;6/1/2001, Vol. 84 Issue 11, p1463 

    We have identified 23 334 individuals (40%) of twins born in Norway 1905-45 where both twins were alive in 1960 without malignant disease. These were linked to the Cancer Registry of Norway. A reduced risk of malignant disease was demonstrated among twins for all tumour sites combined;...

  • Heritability of self-reported asthma and allergy: a study in adult Dutch twins, siblings and parents. Willemsen, Gonneke; Van Beijsterveldt, Toos C. E. M.; Van Baal, Caroline G. C. M.; Postma, Dirkje; Boomsma, Dorret I. // Twin Research & Human Genetics;Apr2008, Vol. 11 Issue 2, p132 

    The present study assessed the prevalence of asthma and allergy, and estimated the importance of genetic and environmental influences on asthma and allergy liability and their association. Longitudinal data on self-reported, doctor-diagnosed asthma and allergy were collected in over 14,000...

  • Announcement: The Sixteenth International Workshop on Methodology of Twin and Family Studies: The Advanced Course March 3th–March 7th, 2003.  // Behavior Genetics;Nov2002, Vol. 32 Issue 6, p499 

    Focuses on the Sixteenth International Workshop on Methodology of Twin and Family Studies in Boulder, Colorado on March 3 to 7, 2003. Local host of the event; Application programming; Registration fee; Provisional faculty roster.

  • Twins may protect against breast cancer. Westall, Jessica // BMJ: British Medical Journal (International Edition);03/22/97, Vol. 314 Issue 7084, p845 

    Reports on the possible role of twin births to protecting a women from breast cancer. Reduction of risk of breast cancer in women who had given birth to twins; Clarification of the role of estrogen and other steroid hormones in the etiology of breast cancer.

  • Heritable breast cancer in twins. Mack, T.M.; Hamilton, A.S.; Press, M.F.; Diep, A.; Rappaport, E.B. // British Journal of Cancer;7/29/2002, Vol. 87 Issue 3, p294 

    Known major mutations such as BRCA1/2 and TP53 only cause a small proportion of heritable breast cancers. Co-dominant genes of lower penetrance that regulate hormones have been thought responsible for most others. Incident breast cancer cases in the identical (monozygotic) twins of...

  • Bilateral retinoblastoma presenting at retinopathy of prematurity screening. Self, J.; Bush, K.; Baral, V. R.; Puvanachandra, N.; Puddy, V. F.; Hodgkins, P. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Apr2010, Vol. 95 Issue 4, pF288 

    The article focuses on bilateral posterior pole retinoblastoma in one of diamniotic, dichorionic, male in vitro fertilisation (IVF) twins at 34 weeks of gestation.

  • Twinship and risk of postmenopausal breast cancer. Cerhan, James R.; Kushi, Lawrence H.; Olson, Janet E.; Rich, Stephen S.; Zheng, Wei; Folsom, Aaron R.; Sellers, Thomas A.; Cerhan, J R; Kushi, L H; Olson, J E; Rich, S S; Zheng, W; Folsom, A R; Sellers, T A // JNCI: Journal of the National Cancer Institute;02/02/2000, Vol. 92 Issue 3, p261 

    Background: Intrauterine exposure to high levels of endogenous estrogens has been hypothesized to increase the risk of breast cancer. Because estrogens and other pregnancy hormones are substantially elevated in twin pregnancies, and possibly more so in dizygotic twin pregnancies, we...

  • Multigene Molecular Profiling in Nasopharyngeal Carcinoma: A Case of Monozygotic Twins. Leo, Qi Jie Nicholas; Lum, Christopher; Loui, William // Hawaii Journal of Medicine & Public Health;2015 Supplement, Vol. 74, p52 

    Introduction: Nasopharyngeal carcinoma (NPC) is an epithelial tumor with high incidence in southern China and Southeast Asia. Oncogene mutation patterns in NPC have yet to be fully elucidated. It is also unclear if the inheritance of oncogene mutations contribute to the development of NPC. Using...

  • Food allergy. Denman, A.M. // British Medical Journal (Clinical Research Edition);4/9/1983, Vol. 286 Issue 6372, p1164 

    Reports the workshop on food allergy organized by Fisons in Harrogate, England. Details on the clinical evidence for food intolerance; Contribution of food intolerance to gastrointestinal disease; Production of long term remission by dietary exclusion in patients with Crohn's disease.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics