TITLE

Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country

AUTHOR(S)
Conen, D.; Wietlisbach, V.; Bovet, P.; Shamlaye, C.; Riesen, W.; Paccaud, F.; Burnier, M.
PUB. DATE
January 2004
SOURCE
BMC Public Health;2004, Vol. 4, p9
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The prevalence of hyperuricemia has rarely been investigated in developing countries. The purpose of the present study was to investigate the prevalence of hyperuricemia and the association between uric acid levels and the various cardiovascular risk factors in a developing country with high average blood pressures (the Seychelles, Indian Ocean, population mainly of African origin). Methods: This cross-sectional health examination survey was based on a population random sample from the Seychelles. It included 1011 subjects aged 25 to 64 years. Blood pressure (BP), body mass index (BMI), waist circumference, waist-to-hip ratio, total and HDL cholesterol, serum triglycerides and serum uric acid were measured. Data were analyzed using scatterplot smoothing techniques and gender-specific linear regression models. Results: The prevalence of a serum uric acid level >420 µmol/L in men was 35.2% and the prevalence of a serum uric acid level >360 µmol/L was 8.7% in women. Serum uric acid was strongly related to serum triglycerides in men as well as in women (r = 0.73 in men and r = 0.59 in women, p < 0.001). Uric acid levels were also significantly associated but to a lesser degree with age, BMI, blood pressure, alcohol and the use of antihypertensive therapy. In a regression model, triglycerides, age, BMI, antihypertensive therapy and alcohol consumption accounted for about 50% (R2) of the serum uric acid variations in men as well as in women. Conclusions: This study shows that the prevalence of hyperuricemia can be high in a developing country such as the Seychelles. Besides alcohol consumption and the use of antihypertensive therapy, mainly diuretics, serum uric acid is markedly associated with parameters of the metabolic syndrome, in particular serum triglycerides. Considering the growing incidence of obesity and metabolic syndrome worldwide and the potential link between hyperuricemia and cardiovascular complications, more emphasis should be put on the evolving prevalence of hyperuricemia in developing countries.
ACCESSION #
29361701

 

Related Articles

  • Continental-Mediterranean and rural-urban differences in cardiovascular risk factors in Croatian population. Bergman Marković, Biserka; Vrdoljak, Davorka; Kranjčević, Ksenija; Vučak, Jasna; Kern, Josipa; Bielen, Ivan; Ivezić Lalić, Dragica; Katić, Milica; Reiner, Željko // Croatian Medical Journal;Aug2011, Vol. 52 Issue 4, p566 

    Aim To compare the distribution of cardiovascular disease (CVD) factors between continental and Mediterranean areas and urban and rural areas of Croatia, as well as to investigate the differences in achieving treatment goals by the general practitioners (GP) in different settings. Methods A...

  • PREECLAMPSIA Y RIESGO CARDIOVASCULAR: ESTUDIO DE SEGUIMIENTO EN LA POBLACIÓN DE GenPE EN COLOMBIA. Cecilia Serrano-Díaz, Norma; Carolina Páez-Leal, María; Andrea Beltrán-Avendaño, Mónica; Carolina Colmenares-Mejía, Claudia; Guio-Mahecha, Elizabeth; Bautista-Niño, Paula // Revista Colombiana de Obstetricia y Ginecologia;jul-sep2012, Vol. 63 Issue 3, p241 

    Introduction: Females having a background of pre-eclampsia (PE) are at greater risk of developing cardiovascular disease. The GenPE study has captured pregnant females with and without PE in Colombia during the last 10 years, making it possible today to evaluate cardiovascular outcomes in this...

  • Serum uric acid and target organ damage in essential hypertension. Ofori, Sandra N.; Odia, Osaretin J. // Vascular Health & Risk Management;2014, Vol. 10, p253 

    Background: Hypertension is a major risk factor for cardiovascular mortality, as it acts through its effects on target organs, such as the heart and kidneys. Hyperuricemia increases cardiovascular risk in patients with hypertension. Objective: To assess the relationship between serum uric acid...

  • Uric acid levels predict future blood pressure and new onset hypertension in the general Japanese population. Takase, H; Kimura, G; Dohi, Y // Journal of Human Hypertension;Sep2014, Vol. 28 Issue 9, p529 

    We tested the hypothesis that uric acid levels predict new-onset hypertension in the Japanese general population. Normotensive individuals who visited our hospital for a yearly health checkup (n=8157, men=61.0% and age=50.7±12.2 years) were enrolled in the present study. After baseline...

  • Should you pay closer attention to serum uric acid levels? Lucas, Beverly D. // Patient Care;9/15/1999, Vol. 33 Issue 14, p18 

    Discusses the association of elevated serum uric acid levels with an increased risk of cardiovascular disease in hypertensive and normotensive patients in three studies presented during the 14th meeting of the American Society for Hypertension. Independent risk factor among elders in a...

  • The cumulative effect of core lifestyle behaviours on the prevalence of hypertension and dyslipidemia. Villegas, Raquel; Kearney, Patricia M; Perry, Ivan J // BMC Public Health;2008, Vol. 8 Issue 1, p210 

    Background: Most cardiovascular disease (CVD) occurs in the presence of traditional risk factors, including hypertension and dyslipidemia, and these in turn are influenced by behavioural factors such as diet and lifestyle. Previous research has identified a group at low risk of CVD based on a...

  • Association of Uric Acid With Vascular Stiffness in the Framingham Heart Study. Mehta, Tapan; Nuccio, Eugene; McFann, Kim; Madero, Magdalena; Sarnak, Mark J.; Jalal, Diana // American Journal of Hypertension;Jul2015, Vol. 28 Issue 7, p877 

    BACKGROUND Uric acid is associated with increased risk of cardiovascular disease and arterial stiffness in patients with hypertension or stroke. It remains unknown if uric acid is associated with arterial stiffness in the general population. METHODS We analyzed the association between serum uric...

  • Blood fat levels are linked to CHD risk.  // Independent Nurse;5/14/2010, p1 

    The article reports on a study which found that people predisposed to have higher levels of blood fat had higher risk of developing coronary heart disease (CHD).

  • Endothelial dysfunction in arterial hypertension. Contreras, F; Rivera, M; Vasquez, J; De la Parte, M A; Velasco, M // Journal of Human Hypertension;Apr2000 Supplement, Vol. 14 Issue 4, pS20 

    Systemic arterial pressure is a dynamic and reactive physiological parameter depending on a great many factors. The endothelial cells of the vascular system are responsible for many biochemical reactions maintaining vascular homeostasis and therefore arterial pressure. Arterial hypertension,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics