TITLE

3-Drug Synergistic Interactions of Small Molecular Inhibitors of Hepatitis C Virus Replication

AUTHOR(S)
Grünberger, Christian; Wyles, David L.; Kaihara, Kelly A.; Schooley, Robert T.
PUB. DATE
January 2008
SOURCE
Journal of Infectious Diseases;1/1/2008, Vol. 197 Issue 1, p42
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Small molecular inhibitors of hepatitis C virus (HCV) replication provide remarkable potency, but the rapid selection of resistance mutations will require that these agents be used in combination for clinical treatment. Using a model HCV replicon system, we have extended prior in vitro studies of double combinations of candidate small molecular inhibitors to studies evaluating the simultaneous use of 3 agents. This was done in an effort to anticipate conditions that might ultimately be required clinically. We formally demonstrate synergistic anti-viral activity with 3-drug combinations in this model, further supporting the concept of clinical investigations of combination therapy for HCV infection.
ACCESSION #
29338299

 

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