Effects of chronic inflammatory bowel diseases on left ventricular structure and function: a study protocol

Cioffi, Ugo; Ciulla, Michele M.; De Simone, Matilde; Paliotti, Roberta; Pierini, Alberto; Magrini, Fabio; Botti, Fiorenzo; Contessini-Avesani, Ettore
January 2002
BMC Public Health;2002, Vol. 2 Issue 1, p19
Academic Journal
Background: Experimental evidences suggest an increased collagen deposition in inflammatory bowel diseases (IBD). In particular, large amounts of collagen type I, III and V have been described and correlated to the development of intestinal fibrotic lesions. No information has been available until now about the possible increased collagen deposition far from the main target organ. In the hypothesis that chronic inflammation and increased collagen metabolism are reflected also in the systemic circulation, we aimed this study to evaluate the effects on left ventricular wall structure by assessing splancnic and systemic collagen metabolism (procollagen III assay), deposition (ultrasonic tissue characterization), and cardiac function (echocardiography) in patients with different long standing history of IBD, before and after surgery. Methods: Thirty patients affected by active IBD, 15 with Crohn and 15 with Ulcerative Colitis, submitted to surgery will be enrolled in the study in a double blind fashion. They will be studied before the surgical operation and 6, 12 months after surgery. A control group of 15 healthy age and gender-matched subjects will also be studied. At each interval blood samples will be collected in order to assess the collagen metabolism; a transthoracic echocardiogram will be recorded for the subsequent determination of cardiac function and collagen deposition. Discussion: From this study protocol we expect additional information about the association between IBD and cardiovascular disorders; in particular to address the question if chronic inflammation, through the altered collagen metabolism, could affect left ventricular structure and function in a manner directly related to the estimated duration of the disease.


Related Articles

  • Purinergic Signaling, Dyslipidemia and Inflammatory Disease. Sparks, Daniel L.; Chatterjee, Cynthia // Cellular Physiology & Biochemistry (Karger AG);2012, Vol. 30 Issue 6, p1333 

    Metabolic syndrome is a compound obesity disorder, wherein the abnormal metabolism of glucose and lipid is associated with the development of chronic inflammatory diseases. The prevalence of this disease is increasing in the developed world, but the causative linkage between these metabolic...

  • Response to Raftery and O'Sullivan. Yarur, Andres J; Deshpande, Amar R; Abreu, Maria T; Sussman, Daniel A // American Journal of Gastroenterology;Nov2011, Vol. 106 Issue 11, p2042 

    A response by A. J. Yarur and colleagues to a letter to the editor about their article "Inflammatory bowel disease is associated with an increased incidence of cardiovascular events" in the 2011 issue is presented.

  • Serum laminin and collagen IV in inflammatory bowel disease. Koutroubakis I E; Petinaki E; Dimoulios P; Vardas E; Roussomoustakaki M; Maniatis A N; Kouroumalis E A // Journal of Clinical Pathology;Nov2003, Vol. 56 Issue 11, p817 

    BACKGROUND:/Aims: Laminin and collagen IV have been proposed as extracellular matrix serum markers. Because fibrosis is a major complication of inflammatory bowel disease, serum concentrations of laminin and collagen IV were measured in patients with ulcerative colitis (UC) and Crohn's disease...

  • Intestinal networks in health and disease. Weiss, Ulla // Nature;6/16/2011, Vol. 474 Issue 7351, p297 

    An introduction is presented in which the editor discusses various reports within the issue on topics on chronic inflammatory bowel disease, colorectal cancer and metabolic disease.

  • The Microvacular Thrombi of Colonic Tissue in Ulcerative Colitis. Guobin He; Qin Ouyang; Daiyun Chen; Fengyuan Li; Jingguo Zhou // Digestive Diseases & Sciences;Sep2007, Vol. 52 Issue 9, p2236 

    Abstract  Mucosal microvacular thrombi in rectal biopsies were observed in some ulcerative colitis (UC). Heparin may be effective in steroid resistant UC in some studies, however, the new results of meta-analysis demonstrated a non-significant effect of heparin in controlled...

  • In-vivo assessment of normal T1 values of the right-ventricular myocardium by cardiac MRI. Kawel-Boehm, N.; Dellas Buser, T.; Greiser, A.; Bieri, O.; Bremerich, J.; Santini, F. // International Journal of Cardiovascular Imaging;Feb2014, Vol. 30 Issue 2, p323 

    To test feasibility of myocardial T1 mapping of the right ventricle (RV) at systole when myocardium is more compact and to determine the most appropriate imaging plane. 20 healthy volunteers (11 men; 33 ± 8 years) were imaged on a 1.5T scanner (MAGNETOM Avanto, Siemens AG, Erlangen, Germany)....

  • Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases.  // BMC Immunology;2012, Vol. 13 Issue 1, p16 

    The article presents a study conducted by the authors to develop immunoassay to assess presence of autoantibodies against collagen VII in patients with inflammatory and autoimmune diseases. Enzyme-linked immunosorbent assay (ELISA) was performed with sera from patients with Crohn's disease,...

  • Elevated serum procollagen type III peptide in splanchnic and peripheral circulation of patients with inflammatory bowel disease submitted to surgery. De Simone, Matilde; Cioffi, Ugo; Contessini-Avesani, Ettore; Oreggia, Barbara; Paliotti, Roberta; Pierini, Alberto; Bolla, Gianni; Oggiano, Elide; Ferrero, Stefano; Magrini, Fabio; Ciulla, Michele M. // BMC Gastroenterology;2004, Vol. 4, p29 

    Background: In the hypothesis that the increased collagen metabolism in the intestinal wall of patients affected by inflammatory bowel disease (IBD) is reflected in the systemic circulation, we aimed the study to evaluate serum level of procollagen III peptide (PIIIP) in peripheral and...

  • Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease. Koelink, Pim J.; Overbeek, Saskia A.; Braber, Saskia; Morgan, Mary E.; Henricks, Paul A. J.; Roda, Mojtaba Abdul; Verspaget, Hein W.; Wolfkamp, Simone C.; te Velde, Anje A.; Jones, Caleb W.; Jackson, Patricia L.; Blalock, J. Edwin; Sparidans, Rolf W.; Kruijtzer, John A. W.; Garssen, Johan; Folkerts, Gert; Kraneveld, Aletta D. // Gut;Apr2014, Vol. 63 Issue 4, p578 

    Objective Proline-glycine-proline (PGP) has been shown to have chemotactic effects on neutrophils via CXCR2 in several lung diseases. PGP is derived from collagen by the combined action of matrix metalloproteinase (MMP) 8 and/or MMP9 and prolyl endopeptidase (PE). We investigated the role of PGP...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics