Macrofilaricides and onchocerciasis control, mathematical modelling of the prospects for elimination

Alley, William Soumbey; Van Oortmarssen, Gerrit G. J.; Boatin, Boakye B. A.; Nagelkerke, Nico N. J. D.; Plaisier, Anton Ap.; Remme, Hans J.; Lazdins, Janis; Borsboom, Gerard J. J. M.; Habbema, J. Dik F.; Alley, W S; van Oortmarssen, G J; Boatin, B A; Nagelkerke, N J; Plaisier, A P; Remme, J H; Lazdins, J; Borsboom, G J; Habbema, J D
January 2001
BMC Public Health;2001, Vol. 1 Issue 1, p12
Academic Journal
journal article
Background: In most endemic parts of the world, onchocerciasis (river blindness) control relies, or will soon rely, exclusively on mass treatment with the microfilaricide ivermectin. Worldwide eradication of the parasite by means of this drug is unlikely. Macrofilaricidal drugs are currently being developed for human use.Methods: We used ONCHOSIM, a microsimulation mathematical model of the dynamics of onchocerciasis transmission, to explore the potentials of a hypothetical macrofilaricidal drug for the elimination of onchocerciasis under different epidemiological conditions, as characterized by previous intervention strategies, vectorial capacity and levels of coverage.Results: With a high vector biting rate and poor coverage, a very effective macrofilaricide would appear to have a substantially higher potential for achieving elimination of the parasite than does ivermectin.Conclusions: Macrofilaricides have a substantially higher potential for achieving onchocerciasis elimination than ivermectin, but high coverage levels are still key. When these drugs become available, onchocerciasis elimination strategies should be reconsidered. In view of the impact of control efforts preceding the introduction of macrofilaricides on the success of elimination, it is important to sustain current control efforts.


Related Articles

  • Macrofilaricidal Activity after Doxycycline Only Treatment of Onchocerca volvulus in an Area of Loa loa Co-Endemicity: A Randomized Controlled Trial. Turner, Joseph D.; Tendongfor, Nicholas; Esum, Mathias; Johnston, Kelly L.; Langley, R. Stuart; Ford, Louise; Faragher, Brian; Specht, Sabine; Mand, Sabine; Hoerauf, Achim; Enyong, Peter; Wanj, Samuel; Taylor, Mark J. // PLoS Neglected Tropical Diseases;Apr2010, Vol. 4 Issue 4, p1 

    Background: The risk of severe adverse events following treatment of onchocerciasis with ivermectin in areas co-endemic with loiasis currently compromises the development of control programmes and the treatment of co-infected individuals. We therefore assessed whether doxycycline treatment could...

  • Eye disease beaten. Heaven, Douglas // New Scientist;8/10/2013, Vol. 219 Issue 2929, p6 

    The article reports that Colombia has become the first country to eradicate river blindness, a disease caused by a parasitic filarial worm, Onchocerca volvulus, that affects people living in 30 countries in Africa and South America.

  • Can ivermectin mass treatments eliminate onchocerciasis in Africa? Winnen, M.; Plaisier, A.P.; Alley, E.S.; Nagelkerke, N.J.D.; van Oortmarssen, G.; Boatin, B.A.; Habbema, J.D.F. // Bulletin of the World Health Organization;2002, Vol. 80 Issue 5, p384 

    Objective To elucidate the conditions in which mass treatment with ivermectin reduces the transmission of Onchocerca volvulus sufficiently to eliminate infection from an African community. Methods ONCHOSIM, a microsimulation model for onchocerciasis transmission, was used to explore the...

  • Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus. Osei-Atweneboana, Mike Y.; Awadzi, Kwablah; Attah, Simon K.; Boakye, Daniel A.; Gyapong, John O.; Prichard, Roger K. // PLoS Neglected Tropical Diseases;Mar2011, Vol. 5 Issue 3, p1 

    Background: Ivermectin (IVM) has been used in Ghana for over two decades for onchocerciasis control. In recent years there have been reports of persistent microfilaridermias despite multiple treatments. This has necessitated a reexamination of its microfilaricidal and suppressive effects on...

  • Assessment Of The Epidemiology Of Onchocerca Volvulus After Treatment With Ivermectin In The Federal Capital Territory, Abuja, Nigeria. Eze, Jonathan; Malau, Matur Bernard // International Journal of Research & Reviews in Applied Sciences;2011, Vol. 7 Issue 3, p319 

    Study area: The study was conducted in the University of Abuja teaching hospital Gwagwalada, Abuja, from February 2009-June 2010. Methodology: five (5) Skin snips were randomly collected from various parts of the body of volunteered onchocercal patients visiting the hospital and incubated inside...

  • Incidence of blindness during the Onchocerciasis control programme in western Africa, 1971-2002. Little, Mark P.; Basánez, Maria-Gloria; Breitling, Lutz Ph.; Boatin, Boakye A.; Alley, Edoh S.; Basanez, Maria-Gloria // Journal of Infectious Diseases;5/15/2004, Vol. 189 Issue 10, p1932 

    Background: Infection with Onchocerca volvulus is associated with the prevalence of severe visual impairment and blindness. However, longitudinal studies of the incidence of blindness caused by onchocerciasis are scarce. Methods: The relationship, at the individual...

  • Uncertainty Surrounding Projections of the Long-Term Impact of Ivermectin Treatment on Human Onchocerciasis. Turner, Hugo C.; Churcher, Thomas S.; Walker, Martin; Osei-Atweneboana, Mike Y.; Prichard, Roger K.; Basáñez, María-Gloria // PLoS Neglected Tropical Diseases;Apr2013, Vol. 7 Issue 4, p1 

    Background: Recent studies in Mali, Nigeria, and Senegal have indicated that annual (or biannual) ivermectin distribution may lead to local elimination of human onchocerciasis in certain African foci. Modelling-based projections have been used to estimate the required duration of ivermectin...

  • A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca volvulus Infection. Awadzi, Kwablah; Opoku, Nicholas O.; Attah, Simon K.; Lazdins-Helds, Janis; Kuesel, Annette C. // PLoS Neglected Tropical Diseases;Jun2014, Vol. 8 Issue 6, p1 

    Background: Control of onchocerciasis as a public health problem in Africa relies on annual mass ivermectin distribution. New tools are needed to achieve elimination of infection. This study determined in a small number of Onchocerca volvulus infected individuals whether moxidectin, a veterinary...

  • Elimination of Onchocerca volvulus Transmission in the Huehuetenango Focus of Guatemala. Cruz-Ortiz, Nancy; Gonzalez, Rodrigo J.; Lindblade, Kim A.; Richards, Frank O.; Sauerbrey, Mauricio; Zea-Flores, Guillermo; Dominguez, Alfredo; Oliva, Orlando; Catú, Eduardo; Rizzo, Nidia // Journal of Parasitology Research;2012, p1 

    In Latin America, onchocerciasis is targeted for elimination by 2012 through twice-yearly mass treatment of the eligible population with ivermectin. In Guatemala, two of the four historical endemic foci have demonstrated elimination of transmission, following World Health Organization...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics