Genetic structure of Indian populations based on fifteen autosomal microsatellite loci

Kashyap, VK; Guha, Saurav; Sitalaximi, T; Bindu, G Hima; Hasnain, Seyed E; Trivedi, R
January 2006
BMC Genetics;2006, Vol. 7, p28
Academic Journal
Background: Indian populations endowed with unparalleled genetic complexity have received a great deal of attention from scientists world over. However, the fundamental question over their ancestry, whether they are all genetically similar or do exhibit differences attributable to ethnicity, language, geography or socio-cultural affiliation is still unresolved. In order to decipher their underlying genetic structure, we undertook a study on 3522 individuals belonging to 54 endogamous Indian populations representing all major ethnic, linguistic and geographic groups and assessed the genetic variation using autosomal microsatellite markers. Results: The distribution of the most frequent allele was uniform across populations, revealing an underlying genetic similarity. Patterns of allele distribution suggestive of ethnic or geographic propinquity were discernible only in a few of the populations and was not applicable to the entire dataset while a number of the populations exhibited distinct identities evident from the occurrence of unique alleles in them. Genetic substructuring was detected among populations originating from northeastern and southern India reflective of their migrational histories and genetic isolation respectively. Conclusion: Our analyses based on autosomal microsatellite markers detected no evidence of general clustering of population groups based on ethnic, linguistic, geographic or socio-cultural affiliations. The existence of substructuring in populations from northeastern and southern India has notable implications for population genetic studies and forensic databases where broad grouping of populations based on such affiliations are frequently employed.


Related Articles

  • Mapping of Rabbit Microsatellite Markers Using Chromosome-Specific Libraries. Korstanje, R.; Gillissen, G.F.; Versteeg, S.A.; van Oost, B.A.; Bosma, A.A.; Rogel-Gaillard, C.; van Zutphen, L.F.M.; van Lith, H.A. // Journal of Heredity;Mar/Apr2003, Vol. 94 Issue 2, p161 

    Presents a study that developed microsatellite markers from chromosome-specific libraries. Position and orientation of the linkage groups on the chromosomes; Molecular characteristics and primer sequences for microsatellite loci; Details on the sequencing of rabbit microsatellite sequences.

  • Y-chromosomal microsatellite mutation rates in a population sample from northwestern Germany. Carsten Hohoff; Ulla Sibbing; Karolin Hoppe; Peter Forster; Bernd Brinkmann // International Journal of Legal Medicine;Sep2007, Vol. 121 Issue 5, p359 

    Abstract  To estimate Y-chromosomal short tandem repeat (Y-STR) mutation rates, 15 loci (i.e., DYS19, DYS389 I/II, DYS390, and DYS393; DYS437, DYS438, DYS439, and DYS385; DYS391, DYS392, YCA II, and DXYS156) were analyzed in a sample of 1,029 father/son pairs from Westphalia,...

  • Genetic Differentiation of Anopheles gambiae s.s. Populations in Mali, West Africa, Using Microsatellite Loci. Carnahan, J.; Zheng, L.; Taylor, C.E.; Toure, Y.T.; Norris, D.E.; Dolo, G.; Diuk-Wasser, M.; Lanzaro, G.C. // Journal of Heredity;Jul/Aug2002, Vol. 93 Issue 4, p249 

    Presents a study that inquired into the question of geographic population genetic structure for microsatellite DNA loci. Chromosomal forms of the genetic structure of Anopheles gambiae sensu stricto in Mali, West Africa; Correlation between the distances of suitable habitat and differences in...

  • Spectrum of Nonramdom Associations Between Microsatellite Loci on Human Chromosome 11p15. Zapata, Carlos; Rodriguez, Santiago; Visedo, Guillermo; Sacristan, Felipe // Genetics;Jul2001, Vol. 158 Issue 3, p1235 

    Examines the frequency and strength of overall and interallelic disequilibrium between pairs of 12 microsatellite loci spanning 19 cM on human chromosome 11p15 from a large sample of Galician population in northwest Spain. Relationship of disequilibrium with frequency of recombination and...

  • Analysis of FMR1 and flanking microsatellite markers in normal and fragile X chromosomes in Portugal: evidence for a “protector” haplotype. Peixoto, Ana; Santos, MR dos; Seruca, Raquel; Amorim, António; Castedo, Sérgio // European Journal of Human Genetics;Sep98, Vol. 6 Issue 5, p518 

    In order to look for linkage disequilibrium between the fragile X locus and its flanking markers, we analysed the FRAXAC1 and DXS548 microsatellites in normal and fragile X individuals of Portuguese origin. We observed differences in allele and haplotype frequencies between these two samples....

  • A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. Zhou, Bing; Westaway, Shawn K.; Levinson, Barbara; Johnson, Monique A.; Gitschier, Jane; Hayflick, Susan J. // Nature Genetics;Aug2001, Vol. 28 Issue 4, p345 

    Hallervorden-Spatz syndrome (HSS) is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Clinical features include extrapyramidal dysfunction, onset in childhood, and a relentlessly progressive course. Histologic study reveals iron deposits in the...

  • Spoken presentations.  // Journal of Medical Genetics;Sep2002 Supplement, Vol. 39, pS31 

    Discusses the abstract of the research paper entitled 'Satellited Autosomes,' by Lionel Willatt and presented during the British Human Genetics Conference at the University of York in England in September 2002.

  • A search for a 'Genghis Khan' chromosome. Zakharov, I. A. // Russian Journal of Genetics;Sep2010, Vol. 46 Issue 9, p1130 

    Zerial et al. (2003) have shown that a special variant of the Y chromosome, characterized by a set of microsatellite markers occurs at high frequency in the number of human populations of Central Asia. This variant was attributed to the descendants of Genghis Khan and its accumulation, to social...

  • Signatures of selection? Patterns of microsatellite diversity on a chromosome containing a selected locus. Wiener, P; Burton, D; Ajmone-Marsan, P; Dunner, S; Mommens, G; Nijman, I J; Rodellar, C; Valentini, A; Williams, J L // Heredity;May2003, Vol. 90 Issue 5, p350 

    This paper explores patterns of genetic diversity near a locus known to have been under selection. The myostatin gene (GDF-8) has been shown to be associated with double muscling, a phenotype selected for in a number of cattle breeds. We examined population genetic parameters for microsatellite...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics