Morphological features in a Xhosa schizophrenia population

Koen, Liezl; Niehaus, Dana J. H.; De Jong, Greetje; Muller, Jacqueline E.; Jordaan, Esme
January 2006
BMC Psychiatry;2006, Vol. 6, p47
Academic Journal
Background: Demonstrating an association between physical malformation and schizophrenia could be considered supportive of a neurodevelopmental origin of schizophrenia and may offer insights into a critical period for the development of this illness. The aim of our study was to investigate whether differences in the presence of minor physical anomalies could be demonstrated between schizophrenia sufferers and normal controls in a Xhosa population with a view to identifying a means of subtyping schizophrenia for use in future genetic studies. Methods: Sixty-three subjects with schizophrenia (21 sibling pairs, 1 sibship of four and a group of probands with an affected non-participating sibling (n = 17)), 81 normal controls (37 singletons and 22 sibling pairs) of Xhosa ethnicity were recruited. Each participant was then examined for minor physical anomalies using the Modified Waldrop scale. The relationship between each of the morphological features and the presence of an affected sib was examined using the Chi-squared test, followed by an intra-pair concordance analysis in the sibling pairs. Results: Gap between first and second toes was significantly more common in the affected sib pair group when compared to the non-affected sib pair group (p = 0.019) and non-affected singleton control group (p = 0.013). Concordance analysis also revealed increased concordance for this item in the affected sib pair group. Conclusion: These findings offer an intriguing possibility that in the Xhosa population, affected sib pair status may be linked to a neurodevelopmental insult during a specific period of the fetal developmental.


Related Articles

  • Schizophrenia and quality of life: a one-year follow-up in four EU countries. Kovess-Masféty, Viviane; Xavier, Miguel; Kustner, Berta Moreno; Suchocka, Agnieszka; Sevilla-Dedieu, Christine; Dubuis, Jacques; Lacalmontie, Elisabeth; Pellet, Jacques; Roelandt, Jean-Luc; Walsh, Dermot // BMC Psychiatry;2006, Vol. 6, p39 

    Background: This article systematically monitors the quality of life (QOL) of patients with schizophrenia from seven different sites across four European countries: France, Ireland, Portugal and Spain. Methods: A one-year prospective cohort study was carried out. Inclusion criteria for patients...

  • Poverty and Ethnicity among Black South Africans. Gradin, Carlos // European Journal of Development Research;Dec2015, Vol. 27 Issue 5, p921 

    This article investigated inequalities across the major black ethnic groups in South Africa, accounting for 80 per cent of the country's population. We have demonstrated that there is an important ethnic gap in the poverty levels and flows of the Xhosa and the Zulu with respect to the...

  • Attitudes to antipsychotic drugs and their side effects: a comparison between general practitioners and the general population. Helbling, Josef; Ajdacic-Gross, Vladeta; Lauber, Christoph; Weyermann, Ruth; Burns, Tom; Rössler, Wulf // BMC Psychiatry;2006, Vol. 6, p42 

    Background: Attitudes towards antipsychotic medication play an important part in the treatment for schizophrenia and related disorders. We aimed measuring general practitioners' attitudes to antipsychotic drugs and their adverse side effects and comparing these with the attitudes of the general...

  • Dysbindin gene ( DTNBP1) and schizophrenia in Korean population. Pae, Chi-Un; Mandelli, Laura; De Ronchi, Diana; Jung-Jin Kim; Tae-Youn Jun; Patkar, Ashwin A.; Serretti, Alessandro // European Archives of Psychiatry & Clinical Neuroscience;Apr2009, Vol. 259 Issue 3, p137 

    Dysbindin gene ( DTNBP1) has been consistently reported to be associated with schizophrenia. However data from East Asian population has been sparse and inconsistent till today. This study tried to replicate the genetic association of DTNBP1 with schizophrenia in a large Korean sample, as well...

  • Subcultural Delusions and Hallucinations. Swartz, L.; Ben-Arie, O.; Teggin, A. F. // British Journal of Psychiatry;Apr85, Vol. 146, p391 

    The challenges presented by the Present State Examination (PSE) in a multi-cultural context are explored. The general approach to the use of this instrument, difficulties with rating items relevant to cultural or subcultural conditions, and particularly the assessment of psychosis are...

  • Support management in schizophrenia: a systematic review of current literature. Pompili, Maurizio; Montebovi, Franco; Forte, Alberto; Palermo, Mario; Stefani, Henry; Telesforo, Ludovica; Campi, Sandra; Giordano, Gloria; Longo, Lucia; Lamis, Dorian A.; Serafini, Gianluca; Girardi, Paolo // Patient Intelligence;2012 Part 2, Vol. 4, p79 

    Background: Schizophrenia is generally considered a chronic disorder characterized by psychotic symptoms and relatively stable neurocognitive and interpersonal deficits. Antipsychotic medication has proven beneficial in reducing psychotic symptoms, but is often not enough to treat cognitive or...

  • Insight dimensions and cognitive function in psychosis: a longitudinal study. Cuesta, Manuel J.; Peralta, Victor; Zarzuela, Amalia; Zandio, Maria // BMC Psychiatry;2006, Vol. 6, p26 

    Background: It has been reported that lack of insight is significantly associated with cognitive disturbance in schizophrenia. This study examines the longitudinal relationships between insight dimensions and cognitive performance in psychosis. Methods: Participants were 75 consecutively...

  • Conceptual and Methodological Issues in the Design of Clinical Trials of Antipsychotics for the Treatment of Schizophrenia. Honer, William G.; Thornton, Allen E.; Sherwood, Megan; MacEwan, G. William; Ehmann, Tom S.; Williams, Richard; Kopala, Lili C.; Procyshyn, Ric; Barr, Alasdair M. // CNS Drugs;2007, Vol. 21 Issue 9, p699 

    Schizophrenia is one of the most severe and disabling psychiatric disorders. Antipsychotic drugs offer considerable benefits in controlling symptoms and preventing relapse. The strategy for the present review of clinical trials was to ask ‘What are the features of schizophrenia and the...

  • Dimensions of Premorbid Functioning in Schizophrenia: A Review of Neuromotor, Cognitive, Social, and Behavioral Domains. Schenkel, Lindsay S.; Silverstein, Steven M. // Genetic, Social & General Psychology Monographs;Aug2004, Vol. 130 Issue 3, p241 

    After a brief discussion of methods for studying the premorbid period in schizophrenia, the authors review relevant experimental literature to assess the validity of current theories. A critical review is provided that includes representative empirical investigations on premorbid functioning in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics