Insight dimensions and cognitive function in psychosis: a longitudinal study

Cuesta, Manuel J.; Peralta, Victor; Zarzuela, Amalia; Zandio, Maria
January 2006
BMC Psychiatry;2006, Vol. 6, p26
Academic Journal
Background: It has been reported that lack of insight is significantly associated with cognitive disturbance in schizophrenia. This study examines the longitudinal relationships between insight dimensions and cognitive performance in psychosis. Methods: Participants were 75 consecutively admitted inpatients with schizophrenia, affective disorder with psychotic symptoms or schizoaffective disorder. Assessments were conducted at two time points during the study: at the time of hospital discharge after an acute psychotic episode and at a follow-up time that occurred more than 6 months after discharge. A multidimensional approach of insight was chosen and three instruments for its assessment were used: the Scale to Assess Unawareness of Mental Disorder (SUMD), three items concerning insight on the Assessment and Documentation in Psychopathology (AMDP) system and the Insight and Treatment Attitudes Questionnaire. The neuropsychological battery included a wide range of tests that assessed global cognitive function, attention, memory, and executive functions. Results: After conducting adequate statistical correction to avoid Type I bias, insight dimensions and cognitive performance were not found to be significantly associated at cross-sectional and longitudinal assessments. In addition, baseline cognitive performance did not explain changes in insight dimensions at follow-up. Similar results were found in the subset of patients with schizophrenia (n = 37). The possibility of a Type II error might have increased due to sample attrition at follow-up. Conclusion: These results suggest that lack of insight dimensions and cognitive functioning may be unrelated phenomena in psychosis.


Related Articles

  • Resolving schizophrenia's CATCH22. Jablensky, Assen // Nature Genetics;Jul2004, Vol. 36 Issue 7, p674 

    Schizophrenia is a severely disabling disorder with a lifetime risk of ~1%, which accounts for 2.8% of the global burden of disease. A new study provides evidence that a third gene in the 22q11 region is associated with schizophrenia, further confounding an already complicated story.

  • The genetic validation of heterogeneity in schizophrenia.  // Behavioral & Brain Functions;2011, Vol. 7 Issue 1, p43 

    The article focuses on a research study related to genetic validation of heterogeneity in schizophrenia. The study aimed to determine if genetic variants strongly suggested by SZGene are associated with risk of schizophrenia in casecontrol samples of Japanese ancestry. In addition, by employing...

  • Prepulse inhibition of auditory change-related cortical responses. Koji Inui; Aki Tsuruhara; Minori Kodaira; Eishi Motomura; Hisashi Tanii; Makoto Nishihara; Sumru Keceli; Ryusuke Kakigi // BMC Neuroscience;2012, Vol. 13 Issue 1, p135 

    Background: Prepulse inhibition (PPI) of the startle response is an important tool to investigate the biology of schizophrenia. PPI is usually observed by use of a startle reflex such as blinking following an intense sound. A similar phenomenon has not been reported for cortical responses....

  • Influence of diagnostic classification on gender ratio in schizophrenia. Beauchamp, Guy; Gagnon, André // Social Psychiatry & Psychiatric Epidemiology;Dec2004, Vol. 39 Issue 12, p1017 

    Background The research literature on hospital admissions for psychoses in youths was reviewed in order to test whether there was a gender ratio discrepancy in diagnostic subgroups; the effect of the diagnostic criteria classification on this measure was also investigated. Method A meta-analysis...

  • Early-onset schizophrenia. Röpcke, Bernd; Eggers, Christian // European Child & Adolescent Psychiatry;Sep2005, Vol. 14 Issue 6, p341 

    The study describes the psychopathological and social outcome of patients treated for schizophrenia in adolescence (mean age at onset 16.0 years/SD 1.52) after a mean follow-up period of 15.4 years (10.2–21.2 years). Out of 55 patients consecutively admitted to hospital, 47 (85 %) could...

  • Zur Psychopathologie der Ich-Störungen. Bürgy, M. // Der Nervenarzt;Sep2010, Vol. 81 Issue 9, p1097 

    The phenomena which Kurt Schneider grouped together to form the ego disturbances have always been of particular diagnostic relevance for schizophrenia. While little importance was historically attached to accurately describing and distinguishing psychopathological symptoms, Karl Jaspers’...

  • Molecular characterization of deletion breakpoints in adults with 22q11 deletion syndrome. Weksberg, Rosanna; Stachon, Andrea C.; Squire, Jeremy A.; Moldovan, Laura; Bayani, Jane; Meyn, Stephen; Chow, Eva; Bassett, Anne S. // Human Genetics;Jan2007, Vol. 120 Issue 6, p837 

    22q11 Deletion syndrome (22q11DS) is a common microdeletion syndrome with variable expression, including congenital and later onset conditions such as schizophrenia. Most studies indicate that expression does not appear to be related to length of the deletion but there is limited information on...

  • What should be done about schizophrenia? Horrobin, David F. // Journal of the Royal Society of Medicine;Mar1981, Vol. 74 Issue 3, p180 

    The article discusses as to what should be done to effectively managed schizophrenia, a psychiatric diagnosis that describes a mental disorder characterized by impairments in the perception or expression of reality and by significant social or occupational dysfunction. The author stresses that a...

  • The Age-distribution of Schizophrenia and Neurosis: Findings in a National Sample. Hare, E. H.; Price, J. S.; Slater, E. T. O. // British Journal of Psychiatry;Oct71, Vol. 119 Issue 551, p445 

    The article presents a study which examines the similarity in the age-incidence curves of schizophrenia and neurosis when sexes are combined. The similarity in age-distribution between schizophrenia and neurosis and between mania and depression has not been specially noticed before. In any study...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics