Psychosis among "healthy" siblings of schizophrenia patients

Arajärvi, Ritva; Ukkola, Jonna; Haukka, Jari; Suvisaari, Jaana; Hintikka, Jukka; Partonen, Timo; Lönnqvist, Jouko
January 2006
BMC Psychiatry;2006, Vol. 6, p6
Academic Journal
Background: Schizophrenia aggregates in families and accurate diagnoses are essential for genetic studies of schizophrenia. In this study, we investigated whether siblings of patients with schizophrenia can be identified as free of any psychotic disorder using only register information. We also analyzed the emergence of psychotic disorders among siblings of patients with schizophrenia during seven to eleven years of follow-up. Methods: A genetically homogenous population isolate in north-eastern Finland having 365 families with 446 patients with a diagnosis of schizophrenia was initially identified in 1991 using four nationwide registers. Between 1998 and 2002, 124 patients and 183 siblings in 110 families were contacted and interviewed using SCID-I, SCID-II and SANS. We also compared the frequency of mental disorders between siblings and a random population comparison group sample. Results: Thirty (16%) siblings received a diagnosis of psychotic disorder in the interview. 14 siblings had had psychotic symptoms already before 1991, while 16 developed psychotic symptoms during the follow-up. Over half of the siblings (n = 99, 54%) had a lifetime diagnosis of any mental disorder in the interview. Conclusion: Register information cannot be used to exclude psychotic disorders among siblings of patients with schizophrenia. The high rate of emergence of new psychotic disorders among initially healthy siblings should be taken into account in genetic analysis.


Related Articles

  • Molecular characterization of deletion breakpoints in adults with 22q11 deletion syndrome. Weksberg, Rosanna; Stachon, Andrea C.; Squire, Jeremy A.; Moldovan, Laura; Bayani, Jane; Meyn, Stephen; Chow, Eva; Bassett, Anne S. // Human Genetics;Jan2007, Vol. 120 Issue 6, p837 

    22q11 Deletion syndrome (22q11DS) is a common microdeletion syndrome with variable expression, including congenital and later onset conditions such as schizophrenia. Most studies indicate that expression does not appear to be related to length of the deletion but there is limited information on...

  • How Prevalent Is Schizophrenia?  // PLoS Medicine;May2005, Vol. 2 Issue 5, p362 

    Presents an abstract of the study "A Systematic Review of the Prevalence of Schizophrenia," by S. Saba, D. Chant, J. Welham and J. McGrath, published in the 2005 issue of "PLoS."

  • Urbanization and traffic related exposures as risk factors for Schizophrenia. Pedersen, Carsten Bøcker; Bo Mortensen, Preben // BMC Psychiatry;2006, Vol. 6, p2 

    Background: Urban birth or upbringing increase schizophrenia risk. Though unknown, the causes of these urban-rural differences have been hypothesized to include, e.g., infections, diet, toxic exposures, social class, or an artefact due to selective migration. Methods: We investigated the...

  • Untreated illness and outcome of psychosis. Clarke, Mary; Whitty, Peter; Browne, Stephen; McTigue, Orfhlaith; Kamali, Moayyad; Gervin, Maurice; Kinsella, Anthony; Waddington, John L.; Larkin, Conal; O'Callaghan, Eadbhard // British Journal of Psychiatry;Sep2006, Vol. 189, p235 

    Background There has been controversy as to whether early intervention in psychosis can improve the outcome of the disorder. Aims To establish if there is an association between duration of untreated psychosis and the 4-year outcome of persons with a first episode of psychosis. Method...

  • Episodic memory-related activation in schizophrenia: meta-analysis. Achim, Amélie M.; Lepage, Martin // British Journal of Psychiatry;Dec2005, Vol. 187, p500 

    Background Numerous studies have examined the neural correlates of episodic memory deficits in schizophrenia, yielding both consistencies and discrepancies in the reported patterns of results. Aims To identify in schizophrenia the brain regions in which activity is consistently abnormal across...

  • Family history, place and season of birth as risk factors for schizophrenia in Denmark: a replication and reanalysis. Pedersen, Carsten Bøcker; Mortensen, Preben Bo // British Journal of Psychiatry;Jul2001, Vol. 179, p46 

    Background Although a family history of schizophrenia is the strongest individual risk factor for schizophrenia, environmental factors related to urbanicity may contribute to a substantial proportion of the population occurrence of the disease. Aims This study replicates previous findings in...

  • Double Bind: Much More Than Just a Step 'Toward a Theory of Schizophrenia'. Cullin, Joel // Australian & New Zealand Journal of Family Therapy;Sep2006, Vol. 27 Issue 3, p135 

    In 1956, Bateson, Jackson, Haley, and Weakland published ‘Toward a Theory of Schizophrenia’. This paper was an early milestone in family therapy's development, signifying the importance that communications theory and cybernetics would hold for the evolution of the field over the...

  • Mapping the pathophysiology of schizophrenia: interactions between multiple cellular pathways. Chao Deng; Dean, Brian // Frontiers in Cellular Neuroscience;Nov2013, Vol. 7, p80 

    An introduction is presented in which the editor discusses various reports within the issue on topics including the search for biomarkers for psychosis and schizophrenia, the features of polysialic acid, and the animal model for schizophrania.

  • Review: lifetime prevalence of schizophrenia and related disorders is about 5.5 per 1000, but there is significant variation between regions. Goldner, E. M. // Evidence Based Mental Health;Aug2003, Vol. 6 Issue 3, p74 

    This article presents a review of lifetime prevalence of schizophrenia and related disorders. It is about 5.5 per 1000, but there is significant variation between region. Authors restricted this review to studies using rigorous and relatively homogeneous methods. Despite this, there was...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics