Alterations of prolyl endopeptidase activity in the plasma of children with autistic spectrum disorders

Momeni, Naghi; Nordström, Berit M.; Horstmann, Vibeke; Avarseji, Hassan; Sivberg, Bengt V.
January 2005
BMC Psychiatry;2005, Vol. 5, p27
Academic Journal
Background: Prolyl Endopeptidase (PEP, EC, a cytosolic endopeptidase, hydrolyses peptide bonds on the carboxyl side of proline residue in proteins with a relatively small molecular weight. It has been shown that altered PEP activity is associated with various psychological diseases such as schizophrenia, mania and depression. Autistic Spectrum Disorders (ASD) are neuropsychiatric and behavioural syndromes affecting social behaviours and communication development. They are classified as developmental disorders. The aim of this study was to examine the hypothesis that PEP activity is also associated with ASDs. Methods: Fluorometric assay was used to measure PEP activity in EDTA plasma in children with ASD (n = 18) aged 4-12 years (mean ± SD: 7.9 ± 2.5). These results were then compared to PEP activity in a control group of non-ASD children (n = 15) aged 2-10 years (mean ± SD: 6.4 ± 2.2). Results: An alteration in PEP activity was found in the children with ASD compared to the control group. There was much greater variation of PEP activity in the group of ASD children when compared to the controls (SD= 39.9 and SD 9.6, respectively). This variation was significant (p < 0.0005), although the mean level of PEP activity in the group of ASD children was slightly higher than in the control group (124.4 and 134.1, respectively). Conclusion: Our preliminary finding suggests a role for PEP enzyme in the pathophysiology of autism but further research should be conducted to establish its role in the aetiology of psychiatric and neurological disorders, including autism and related spectrum disorders.


Related Articles

  • Effectiveness of pivotal response treatment on communicative and behavioral disorder of 8-12 years-old autistic boys. Salemi Khamene, A.; Ghahari, Sh.; Soltanlou, M.; Darabi, J. // Journal of Gorgan University of Medical Sciences;Spring2013, Vol. 15 Issue 1, p6 

    Background and Objective: Autism is one the most disturbing neurodevelopmental disorders associated with any kinds of communicative problems and physical objects. This study was done to evaluate the effectiveness of pivotal response treatment on communicative and behavioral disorder of 8-12...

  • Development problems were common five years after positive screening for language disorders and, or, autism at 2.5 years of age. Miniscalco, Carmela; Fernell, Elisabeth; Thompson, Lucy; Sandberg, Eva; Kadesjö, Björn; Gillberg, Christopher // Acta Paediatrica;Oct2018, Vol. 107 Issue 10, p1739 

    Aim: This study identified whether children who had screened positive for either developmental language disorder (DLD) or autism spectrum disorder (ASD) at the age of 2.5 years had neurodevelopmental assessments five years later.Methods: Our study cohort were 288...

  • Subtle Executive Impairment in Children with Autism and Children with ADHD. Goldberg, M.; Mostofsky, S. H.; Cutting, L. E.; Mahone, E. M.; Astor, B. C.; Denckla, M. B.; Landa, R. J. // Journal of Autism & Developmental Disorders;Jun2005, Vol. 35 Issue 3, p279 

    Background: The executive functions of inhibition, planning, flexible shifting of actions, and working memory are commonly reported to be impaired in neurodevelopmental disorders. Method: We compared these abilities in children (8–12 years) with high functioning autism (HFA, n = 17),...

  • Issues and Trends in Treatment of Children with Autism Spectrum Disorders. Weaver, Betsy; Hersey, Miranda // Exceptional Parent;Apr2002, Vol. 32 Issue 4, p20 

    Provides information on the treatment of children with autism spectrum disorders. Diagnosis; Treatment approaches to use; Shortage of qualified care providers.

  • All About Autism. Klein, Melissa // Current Health 2;Oct2007, Vol. 34 Issue 2, p26 

    The article focuses on the increase in the prevalence of the developmental disorder Autism, which according to the U.S. government statistics is one in 150 8-year-olds.

  • Visually cued instruction for children with autism and pervasive developmental disorders. Quill, Kathleen Ann // Focus on Autistic Behavior;Aug95, Vol. 10 Issue 3, p10 

    Summarizes instructional strategies that take into account the cognitive processes and social-communicative differences that underlie autism and pervasive developmental disorders. Theoretical rationale for visually cued instruction; Intervention issues; Examples of pictographic and written...

  • Can kids be a little autistic? Dreisbach, Shaun // Parenting School Years;Aug2010, Vol. 24 Issue 7, p44 

    The article discusses a research study which shows that for every child who is diagnosed to have autism there is one other who is not found to have the disorder.

  • Journey Into Autism. Collins, Abby Ward; Collins, Sibley J. // Focus on Autism & Other Developmental Disabilities;Spring2001, Vol. 16 Issue 1, p20 

    Discusses a case of autism from a mother's account. Fertility problem and prescribed medicine; Signs of autism that she missed through 18 months; Result of the baby's 24-month checkup and some observations on his abilities; Confirmation of preliminary impression of autism; How the mother coped...

  • The Grief Cycle--One Parent's Trip Around. Boushey, Ann // Focus on Autism & Other Developmental Disabilities;Spring2001, Vol. 16 Issue 1, p27 

    Discusses the experiences of a mother of a boy with high-functioning autism, as she learns to accept her son's differences. Initial reaction upon the discovery of the problem; Understanding the grief cycle of acceptance from the denial stage to bargaining; Acceptance and hope.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics