TITLE

No evidence for association between polymorphisms in GRM3 and schizophrenia

AUTHOR(S)
Norton, Nadine; Williams, Hywel J.; Dwyer, Sarah; Ivanov, Dobril; Preece, Anna C.; Gerrish, Amy; Williams, Nigel M.; Yerassimou, Pamela; Zammit, Stanley; O'Donovan, Michael C.; Owen, Michael J.
PUB. DATE
January 2005
SOURCE
BMC Psychiatry;2005, Vol. 5, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3. Methods: In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples. Results: Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns. Conclusion: Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.
ACCESSION #
29323706

 

Related Articles

  • MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese. He, G.; Liu, X.; Qin, W.; Chen, Q.; Wang, X.; Yang, Y.; Zhou, J.; Xu, Y.; Gu, N.; Feng, G.; Sang, H.; Wang, P.; He, L. // Molecular Psychiatry;Aug2006, Vol. 11 Issue 8, p748 

    The MPZL1/PZR gene has been mapped to 1q23.3, located in close proximity to a recognized schizophrenia susceptibility locus. Recently, the MPZL1/PZR gene has been found to be significantly upregulated in schizophrenia brain tissue and to play an important role in cell signaling, thus indicating...

  • Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. O'Donovan, M. C.; Norton, N.; Williams, H.; Peirce, T.; Moskvina, V.; Nikolov, I.; Hamshere, M.; Carroll, L.; Georgieva, L.; Dwyer, S.; Holmans, P.; Marchini, J. L.; Spencer, C. C. A.; Howie, B.; Leung, H.-T.; Giegling, I.; Hartmann, A. M.; M�ller, H.-J.; Morris, D. W.; Shi, Y. // Molecular Psychiatry;Jan2009, Vol. 14 Issue 1, p30 

    We and others have previously reported linkage to schizophrenia on chromosome 10q25�q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25�q26 that had been typed in a genome-wide...

  • Association of DISC1 with autism and Asperger syndrome. Kilpinen, H.; Ylisaukko-oja, T.; Hennah, W.; Palo, O. M.; Varilo, T.; Vanhala, R.; Nieminen-von Wendt, T.; von Wendt, L.; Paunio, T.; Peltonen, L. // Molecular Psychiatry;Feb2008, Vol. 13 Issue 2, p187 

    The DISC1 gene at 1q42 has generated considerable interest in various psychiatric diseases, since a balanced translocation interrupting the gene was found to cosegregate with schizophrenia and related mental illnesses in a large Scottish pedigree. To date, linkage and association findings to...

  • Thought disorder in schizophrenia. Testing models through confirmatory factor analysis. Cuesta, Manuel J.; Peralta, Victor // European Archives of Psychiatry & Clinical Neuroscience;1999, Vol. 249 Issue 2, p55 

    Abstract Theoretical and empirical models of thought disorder (ThD) were tested through Confirmatory factor analysis (CFA). A sample of 253 DSM-III-R acute schizophrenic patients consecutively admitted was studied. A semistructured interview for schizophrenia was used for diagnosis, and ThD was...

  • Predicting schizophrenia: findings from the Edinburgh High-Risk Study. Johnstone, Eve C.; Ebmeier, Klaus P.; Miller, Patrick; Owens, David G. C.; Lawrie, Stephen M. // British Journal of Psychiatry;Jan2005, Vol. 186, p18 

    Background The hypothesis that schizophrenia is neurodevelopmental was investigated in a prospective study of young people with a postulated 10-5% risk for the development of schizophrenia. Aims To determine premorbid variables distinguishing high-risk people who will go on to develop...

  • Family-based association study of Epsin 4 and Schizophrenia. Tang, R. Q.; Zhao, X. Z.; Shi, Y. Y.; Tang, W.; Gu, N. F.; Feng, G. Y.; Xing, Y. L.; Zhu, S. M.; Sang, H.; Liang, P. J.; He, L. // Molecular Psychiatry;Apr2006, Vol. 11 Issue 4, p395 

    Recently, Pimm et al. identified Epsin 4 on chromosome 5q33 as a susceptibility gene for schizophrenia in the British population, based on linkage and association evidence. In Pimm's case-control study, both the single polymorphisms and the individual haplotypes at the 5′ end of the gene...

  • A Recombination Hotspot in a Schizophrenia-Associated Region of GABRB2. Siu-Kin Ng; Wing-Sze Lo; Pun, Frank W.; Cunyou Zhao; Zhiliang Yu; Jianhuan Chen; Ka-Lok Tong; Zhiwen Xu; Shui-Ying Tsang; Qiang Yang; Weichuan Yu; Nimgaonkar, Vishwajit; Stöber, Gerald; Harano, Mutsuo; Hong Xue // PLoS ONE;2010, Vol. 5 Issue 3, p1 

    Background: Schizophrenia is a major disorder with complex genetic mechanisms. Earlier, population genetic studies revealed the occurrence of strong positive selection in the GABRB2 gene encoding the β2 subunit of GABAA receptors, within a segment of 3,551 bp harboring twenty-nine single...

  • A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics. Malhotra, A.K.; Goldman, D.; Mazzanti, C.; Clifton, A.; Breier, A.; Pickar, D. // Molecular Psychiatry;1998, Vol. 3 Issue 4, p328 

    The neurotransmitter serotonin has been implicated in the pathophysiology of psychosis. The serotonin transporter (5-HTT) plays a critical role in regulation of serotonergic function. A recently identified polymorphism in the promoter region of the 5-HTT gene (5-HTTLPR) produces significant...

  • ZDHHC8 as a candidate gene for schizophrenia: Analysis of a putative functional intronic marker in case-control and family-based association studies. Faul, Thomas; Gawlik, Micha; Bauer, Martin; Jung, Sven; Pfuhlmann, Bruno; Jabs, Burkhard; Knapp, Michael; Stöber, Gerald // BMC Psychiatry;2005, Vol. 5, p1 

    Background: The chromosome 22q11 region is proposed as a major candidate locus for susceptibility genes to schizophrenia. Recently, the gene ZDHHC8 encoding a putative palmitoyltransferase at 22q11 was proposed to increase liability to schizophrenia based on both animal models and human...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics