TITLE

Add-on topiramate reduces weight in overweight patients with affective disorders: a clinical case series

AUTHOR(S)
Kirov, George; Tredget, John
PUB. DATE
January 2005
SOURCE
BMC Psychiatry;2005, Vol. 5, p19
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The weight-gain caused by many psychotropic drugs is a major cause for poor compliance with such medications and could also increase cardio-vascular morbidity among psychiatric patients. Recent reports have shown that the anticonvulsant topiramate causes weight loss in various patient groups. The drug has also shown effectiveness in open trials as a mood stabilizer in patients with affective disorders, but not in controlled trials in the acute treatment of mania. We used topiramate to treat 12 patients with affective disorders who had a body-mass index >30 kg/m². Methods: Topiramate was prescribed as part of our routine clinical practice, as an add-on medication, or as a replacement of a mood stabilizer. Patients' weight was recorded in 1 to 2 monthly intervals. Patients were followed up for between 6 and 12 months. The final dose of topiramate varied from 200 to 600 mg/day. Results: Topiramate was effective in reducing the weight in 10 out of the 12 patients. At six months the 12 patients had lost a mean of 7.75 kg (SD = 6.9 kg, p < 0.001) and at 12 months 9 patients had lost a mean of 9.61 kg (SD = 6.7 kg, p = 0.003). Three patients stopped the treatment: one due to side effects, one due to possible side effects, and one suffered a manic relapse and showed no sustained weight loss. There were no other clear changes in the course of illness of the patients. Conclusion: The evidence of a strong weight-reducing potential of topiramate is indisputable and clinically significant. Topiramate could be considered in the treatment of bipolar patients who are overweight, or whose concerns about weight gain compromise their compliance with long-term prophylactic medication. So far there is no evidence that topiramate has anti-manic effect and it should not be used as monotherapy.
ACCESSION #
29323702

 

Related Articles

  • Weighty matters. Herkes, Geoffrey K. // Journal of Neurology, Neurosurgery & Psychiatry;Jul2013, Vol. 84 Issue 7, p711 

    The article offers information on the study done by a researcher W.O. Pickrell and colleagues on the enhanced use of antiepileptic drug therapy for epilepsy and mood disorders. It mentions that use of antiepileptic drugs leads to increase in the weight of the patients which results in poor...

  • Psychiatric Drugs And Weight Gain in Children.  // Nutrition Health Review: The Consumer's Medical Journal;2010, Issue 102, p17 

    The article reports that according to recent research, some children and adolescents, who take psychiatric medications gain substantial amounts of weight. Christoph Correll and his team at Zucker Hillside Hospital in Glen Oaks, New York, have monitored 257 such children between the ages of 4 and...

  • OBESITY. TATUM IV, WILLIAM O.; KAPLAN, PETER W.; JALLON, PIERRE // Epilepsy A to Z: A Concise Encyclopedia;2009, p238 

    An encyclopedia entry for "Obesity" is presented. It offers clinical information on obesity in relation to epilepsy. Obesity is said to be prevalent in the U.S. and is associated with various medical conditions such as hypertension, diabetes and cancer. Drugs that were found to promote weight...

  • Antidepressant Weight Gain.  // Mayo Clinic Women's Health Source;Dec2005, Vol. 9 Issue 12, p10 

    Reports that weight gain can be a side effect of antidepressants. Causes of weight gain; Ways of coping with increased appetite.

  • Topiramate.  // Reactions Weekly;Oct2015, Vol. 1572 Issue 1, p196 

    The article presents a case study of a 44-year-old man who developed hyperammonaemic encephalopathy leading to encephalopathy after being treated with topiramate for mood disorder.

  • Comparative efficacy of antiepileptic drugs and lacosamide in patients with epilepsy due to an underlying brain lesion. Yadav, Jai Singh; Tripathi, Maheshwar Nath; Kaur, Samiksha; Singh, Tej Bali // Dysphrenia;2013, Vol. 4 Issue 2, p127 

    Aim: We aimed to compare the efficacy of other antiepileptic drugs (AEDs) to lacosamide (LCM) in patients with epilepsy due to an underlying brain lesion. Methods: Total fifty patients were screened for the study. The sociodemographic data, side effects, frequency of seizures recorded and...

  • Topiramate.  // Reactions Weekly;6/26/2004, Issue 1007, p17 

    Presents a case study of a boy who has developed a hypersensitivity reaction to topiramate. Side effects of the drug; Drugs that were added in the therapy to improve seizure control.

  • Current Literature Antiepileptic Drugs: Don't Sweat It! French, Jacqueline A. // Epilepsy Currents;Jan2004, Vol. 4 Issue 1, p33 

    Ben-Zeev B, Watemberg N, Augarten A, Brand N, Yahav Y, Efrati O, Topper L, Blatt I J Child Neurol 2003;18:254–257 In a 6-year-old boy with partial complex seizures, recurrent episodes of hyperthermia developed 2 months after topiramate (TPM) was introduced into his antiepilepsy drug...

  • Topiramate.  // Reactions Weekly;8/11/2007, Issue 1164, p23 

    The article describes the cases of two patients who developed facial myclonus during treatment with topiramate. It references a study by E. Kutluay and colleagues published in the July 25, 2007 issue of the journal "Epilepsia." An overview of the patients' medical history is provided. The...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics