TITLE

The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study

AUTHOR(S)
Farmer, Anne; Breen, Gerome; Brewster, Shyama; Craddock, Nick; Gill, Mike; Korszun, Ania; Maier, Wolfgang; Middleton, Lefkos; Mors, Ole; Owen, Mike; Perry, Julia; Preisig, Martin; Rietschel, Marcella; Reich, Theodore; Jones, Lisa; Jones, Ian; McGuffin, Peter
PUB. DATE
January 2004
SOURCE
BMC Psychiatry;2004, Vol. 4, p42
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The Depression Network Study (DeNt) is a multicentre study designed to identify genes and/or loci linked to and/or associated with susceptibility to unipolar depression in Caucasian families. This study presents the method and socio-demographic details of the first 470 affected sibling pairs recruited from 8 different sites in Europe and the United States of America. Methods: Probands fulfilling either the Diagnostic and Statistical Manual 4th edition (DSM-IV) or the International Classification of Diseases 10th edition (ICD-10) criteria for recurrent unipolar depression of moderate or severe degree and who had at least one similarly affected sibling were eligible for the study. Detailed clinical and psychological assessments were undertaken on all subjects including an interview using the Schedules for Clinical Assessment in Neuropsychiatry. Blood samples were collected from all participants to extract DNA for linkage analysis. Results: The different sites used different recruitment strategies depending on local health care organisation but despite this there was remarkable similarity across sites for the subjects recruited. Although the Bonn site had significantly older subjects both for age of onset and age at interview, for the sample as a whole, subjects were interviewed in their mid-40s and had experienced the onset of their recurrent depression in their 20s. Preliminary genome screening was able to include 929 out of the 944 subjects (98.4%) typed at 932 autosomal and 544 X chromosome markers Conclusions: This paper describes the methodology and the characteristics of the subjects from the 414 families included in the first wave of genotyping from the multi-site DeNT study. Ultimately the study aims to collect affected sibling pairs from approximately 1200 families.
ACCESSION #
29323682

 

Related Articles

  • Gene Linked to Depression.  // Journal of Dental Hygiene;Summer2003, Vol. 77 Issue 3, p184 

    Reports a study published in the July 18, 2003, issue of 'Science,' which reveals that people with a specific gene who experienced multiple stressful life events over a five-year period were more likely to develop depression. Identification of the serotonin-transporter gene as a possible risk...

  • Racial differences in blood pressure control: potential explanatory factors. Bosworth, Hayden B.; Powers, Benjamin; Grubber, Janet M.; Thorpe, Carolyn T.; Olsen, Maren K.; Orr, Melinda; Oddone, Eugene Z. // JGIM: Journal of General Internal Medicine;May2008, Vol. 23 Issue 5, p692 

    Objective: The objective of the study was to identify potential explanatory factors for racial differences in blood pressure (BP) control.Design: The design of the study was a cross-sectional studyPatients/participants: The study included 608 patients with...

  • Pass It Along: Genes alone do not explain depression in families. Knaresboro, Tarah // Psychology Today;Mar/Apr2012, Vol. 45 Issue 2, p10 

    The article reports on a study at New York's Mount Sinai Medical School which suggests that there are subtle ways negative parental experience can give rise to depression among offspring. The study exposed a normal male mice to larger, more aggressive mice and then induced a state of social...

  • Güreşçilerin saldırganlık düzeylerinin sosyo-demografik açıdan incelenmesi (Ankara örneÄŸi). Ersoy, Adnan; Tazegül, Ünsal; Sancaklı, Hamdi // International Journal of Human Sciences;Jan-Jun2012, Vol. 9 Issue 1, p386 

    The aim of the study is to survey the level of aggression of young male wrestlers according to socio-demographic features. For this aim Aggression Scale, created by Tuzgöl(1998), used. The obtained data has been resolved by using spss package program 15 and seen that the data is non...

  • Sobering Development: Falling Pubertal Age in Girls. Greenfield, Russell H. // Alternative Medicine Alert;Oct2010, Vol. 13 Issue 10, p117 

    THE AUTHORS OF THIS CROSS-SECTIONAL LONGITUDINAL study sought to describe methods for assessing pubertal stage of development that were effective across multiple sites, and to report the maturation stages of a cohort of girls aged 7-8 years. Data collection occurred at three sites across the...

  • Injuries in Working Populations: Black-white Differences. Wagener, Diane K.; Winn, Deborah W. // American Journal of Public Health;Nov91, Vol. 81 Issue 11, p1408 

    Background. Although "accidents and adverse effects" mortality is higher among Blacks than Whites, annual injury rates reported in the National Health Interview Survey (NHIS) are lower among Black. We evaluated the influence of sociodemographic risk factors on injury rates among working adults....

  • STRUCTURE AND MOTIVES OF VISITORS TO THE EVENT "EVENINGS OF TEÅ NJAR" (SERBIA). Dimitrić, Dragana; Bjeljac, Željko // Journal of the Geographical Institute 'Jovan Cvijic' SASA;2015, Vol. 65 Issue 2, p215 

    This paper is a continuation of the research on the socio-demographic structure, as well as the motives of visitors of tourist events in Serbia. So far, the events with the prevailing music, ethnographic, economic and entertaining tourist contents of the program have been explored. In this...

  • FACTORES PRESENTES EN LA DESERCIÓN UNIVERSITARIA EN LA FACULTAD DE PSICOLOGÍA DE LA UNIVERSIDAD DE SAN BUENAVENTURA, SEDE BOGOTÁ EN EL PERIODO COMPRENDIDO ENTRE 1998-2009. Mateus Rodríguez, María Juliana; Hernández, Consuelo Herrera; Suárez, Catalina Perilla; Quecan, Gilma Parra; Maldonado, Anderssen Vera // Psychologia;2011, Vol. 5 Issue 1, p121 

    The purpose of this study was to describe the categories as well as the socio-demographic aspects of Ethington's psychological model, present in the university dropout. In order to do that, those aspects were assessed using a telephone survey validated by judges. Participants were between 16 and...

  • ÖĞRETÄ°M ELEMANLARININ TÃœKENMÄ°ÅžLÄ°K DÃœZEYLERÄ° Ä°LE SOSYODEMOGRAFÄ°K DEĞİŞKENLERÄ° ARASINDAKÄ° Ä°LÄ°ÅžKÄ°. GEZER, Engin; YENEL, Fatih; ŞAHAN, Hasan // Journal of International Social Research;Feb2009, Vol. 1 Issue 6, p243 

    In this study, it is aimed to determine the burnout levels of academicians of BESYO (high school of physical education and sports) and its relation to personal and vocational features. The sample chosen for the research comprises 365 (285 man, 80 woman) academicians of BESYO. To find out the...

Share

Read the Article

Courtesy of NEW JERSEY STATE LIBRARY

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics