TITLE

High vitamin B12 level and good treatment outcome may be associated in major depressive disorder

AUTHOR(S)
Hintikka, Jukka; Tolmunen, Tommi; Tanskanen, Antti; Viinamäki, Heimo
PUB. DATE
January 2003
SOURCE
BMC Psychiatry;2003, Vol. 3, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Despite of an increasing body of research the associations between vitamin B12 and folate levels and the treatment outcome in depressive disorders are still unsolved. We therefore conducted this naturalistic prospective follow-up study. Our aim was to determine whether there were any associations between the vitamin B12 and folate level and the six-month treatment outcome in patients with major depressive disorder. Because vitamin B12 and folate deficiency may result in changes in haematological indices, including mean corpuscular volume, red blood cell count and hematocrit, we also examined whether these indices were associated with the treatment outcome. Methods: Haematological indices, erythrocyte folate and serum vitamin B12 levels were determined in 115 outpatients with DSM-III-R major depressive disorder at baseline and serum vitamin B12 level again on six-month follow-up. The 17-item Hamilton Depression Rating Scale was also compiled, respectively. In the statistical analysis we used chi-squared test, Pearson's correlation coefficient, the Student's t-test, analysis of variance (ANOVA), and univariate and multivariate linear regression analysis. Results: Higher vitamin B12 levels significantly associated with a better outcome. The association between the folate level and treatment outcome was weak and probably not independent. No relationship was found between haematological indices and the six-month outcome. Conclusion: The vitamin B12 level and the probability of recovery from major depression may be positively associated. Nevertheless, further studies are suggested to confirm this finding.
ACCESSION #
29323637

 

Related Articles

  • Folate, vitamin B12, plasma thiols and cognitive function in an elderly population sample. Roach, P. D.; Naumovski, N.; Dufficy, L.; Lucock, M.; Blades, B.; Lewis, P.; Sturm, J.; Veysey, M. // Asia Pacific Journal of Clinical Nutrition;2005 Supplement, Vol. 14, pS49 

    Background -- The plasma thiols, especially homocysteine (HCY), folate and vitamin B12 (VitB12) have been implicated in the aetiology of cognitive impairment, anxiety and depression in the elderly. Objective -- The aim of the study was to determine whether there was a relationship between plasma...

  • Major Depresif BozukluÄŸu Olan Hastalarda Essitaloprama Folik Asit Ekleme Tedavisi Ve Serum Homosistein, Folat, B-12 Vitamini Düzeyleri. Ateş, M. Alpay; Algül, Ayhan; Yılmaz, Onur; Geçici, Ömer; İpçioğlu, Osman Metin; Semiz, Ümit Başar; Basoğlu, Cengiz; Ebrinç, Servet; Özcan, Ömer; Kılıç, Selim; çetin, Mesut // Klinik Psikofarmakoloji Bulteni;Mar2009 Supplement, Vol. 19, pS151 

    Objective: Folate supplementation in Major Depressive Disorder (MDD) has been studied in clinic researchs with promising results. The primary objective of this trial is to estimate the effect of essitalopram and folate augmentation in new treatment of MDD. Secondary objectives are to evaluate...

  • Multiple Vitamin/Mineral Boosts Mental Health in Older Adults. Burke, Cathy // Life Extension;Nov2007, Vol. 13 Issue 11, p18 

    The article reports on the result of the study concerning the benefits offered by multivitamins and minerals towards the mental health of older people. The study was participated by 225 hospitalized old patients where they were administered with folate and vitamin B12 and placebo. A comparison...

  • cobalamin.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p473 

    An encyclopedia entry for "cobalamin," also known as vitamin B12 is presented.

  • Homocysteine, Folate and Vitamin B12 Concentrations in Middle Aged Adults Presenting with Sensorineural Hearing Impairment. Gocer, Celil; Genc, Umut; Eryilmaz, Adil; Islam, Ahmet; Boynuegri, Suleyman; Bakira, Fatih // Journal of International Advanced Otology;2009, Vol. 5 Issue 3, p340 

    Objective: Aim of this study was to investigate a possible association between hearing impairment and homocysteine, folate and vitamin B12 concentrations in subjects presenting with sensorineural hearing loss before the geriatric age, namely before the age of 60. Materials and Methods: Pure tone...

  • Psychotic Disorder and Extrapyramidal Symptoms Associated with Vitamin B12 and Folate Deficiency. Murat Dogan; Osman Ozdemir; Ertan A. Sal; S. Zehra Dogan; Pinar Ozdemir; Yasar Cesur; Hüseyin Caksen // Journal of Tropical Pediatrics;Jun2009, Vol. 55 Issue 3, p205 

    Vitamin B12 and folate deficiency causing neuropsychiatric and thrombotic manifestations, such as peripheral neuropathy, subacute combined degeneration of cord, dementia, ataxia, optic atrophy, catatonia, psychosis, mood disturbances, myocardial infarction and portal vein thrombosis are well...

  • Discussion: Causes of vitamin B12 and folate deficiencies. Carmel, Ralph // Food & Nutrition Bulletin;Jun2008 Supplement, Vol. 29, pS35 

    The article examines the major causes of vitamin B12 and folate deficiencies. It states that vegetarians are more likely prone to the risk of such deficiencies. It also highlights the intrinsic factor that is commonly observed in low intake of food sources rich in vitamins. Malabsorption is also...

  • Discussion: Indicators for assessing folate and vitamin B12 status and for monitoring the efficacy of intervention strategies. Green, Tim // Food & Nutrition Bulletin;Jun2008 Supplement, Vol. 29, pS64 

    The article focuses on the use of fortification and supplements to prevent the widespread deficiencies of folate and vitamin12 which affect morbidity rates in the U.S. It highlights laboratory indicators that reflect metabolic function of the vitamin can be used. It also features the measurement...

  • Potential for Misdiagnosis Due to Lack of Metabolic Derangement in Combined Methylmalonic Aciduria/Hyperhomocysteinemia (cblC) in the Neonate. Harding, Cary O; Pillers, De-Ann M; Steiner, Robert D; Bottiglieri, Teodoro; Rosenblatt, David S; Debley, Jason; Michael Gibson, K // Journal of Perinatology;Jul2003, Vol. 23 Issue 5, p384 

    We report two infants with an inborn error of cobalamin (vitamin B[SUB12]) metabolism whose clinical presentation in the first month of life strongly suggested bacterial or viral sepsis. The absence of any acute metabolic derangement (acidosis, hyperammonemia, hypoglycemia, or ketosis) in...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics