TITLE

No association between the sigma receptor type 1 gene and schizophrenia: results of analysis and meta-analysis of case-control studies

AUTHOR(S)
Uchida, Naohiko; Ujike, Hiroshi; Nakata, Kenji; Takaki, Manabu; Nomura, Akira; Katsu, Takeshi; Tanaka, Yuji; Imamura, Takaki; Sakai, Ayumu; Kuroda, Shigetoshi
PUB. DATE
January 2003
SOURCE
BMC Psychiatry;2003, Vol. 3, p13
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Several lines of evidence have supported possible roles of the sigma receptors in the etiology of schizophrenia and mechanisms of antipsychotic efficacy. An association study provided genetic evidence that the sigma receptor type 1 gene (SIGMAR1) was a possible susceptibility factor for schizophrenia, however, it was not replicated by a subsequent study. It is necessary to evaluate further the possibility that the SIGMAR1 gene is associated with susceptibility to schizophrenia. Methods: A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies. Results: There was no significant association of any allele or genotype of the polymorphisms with schizophrenia. Neither significant association was observed with hebephrenic or paranoid subtype of schizophrenia. Furthermore, a meta-analysis including the present and previous studies comprising 779 controls and 636 schizophrenics also revealed no significant association between the SIGMAR1 gene and schizophrenia. Conclusion: In view of this evidence, it is likely that the SIGMAR1 gene does not confer susceptibility to schizophrenia.
ACCESSION #
29323633

 

Related Articles

  • Funkcjonalny polimorfizm genów enzymów inaktywujÄ…cych aminy biogenne a deficyty procesów poznawczych w schizofrenii paranoidalnej. Tylec, Aneta; Kucharska-Pietura, Katarzyna; Jeleniewicz, Witold; Cybulski, Marek; Czernikiewicz, Andrzej // Psychiatria Polska;2013, Vol. 47 Issue 2, p197 

    Aim. The aim of the work was to assess relationship between gene polymorphism of enzymes influencing dopaminergic-, serotoninergic, and noradrenergic transfer and cognitive functioning of paranoid schizophrenic inpatients (ICD-10). Method. The following methods have been used in the study: The...

  • A propósito de un caso: colitis isquémica relación con clozapina. Rodriguez-Sosa, Juana T.; Lázaro-Archilla, Jorge; Trujillo-Cubas, Angel // Actas Espanolas de Psiquiatria;nov/dic2014, Vol. 42 Issue 6, p325 

    No abstract available.

  • Antipsychotics.  // Reactions Weekly;3/31/2007, Issue 1145, p6 

    The article discusses two case studies involving two men who developed oculogyric crisis after taking antipsychotics. The first patient was hospitalized with relapsed schizophrenic psychosis while the second patient has a history of paranoid schizophrenia. Quetiapine was used to treat both patients.

  • Padlock in Scrotum in a Patient with Paranoid Schizophrenia. Merino-Salas, Sergio; Arrabal-Polo, Miguel Angel; Pintado, Fernando Lopez-Carmona; Escobar, Jose Luis; Arrabal-Martin, Miguel; Zuluaga-Gomez, Armando // Archives of Sexual Behavior;Jun2011, Vol. 40 Issue 3, p493 

    The article presents a case study of a 44-year-old male patient who was diagnosed with paranoid schizophrenia 23 years ago. He was admitted to hospital on several occasions during the first 10 years of his illness because of non-compliance with pharmacological treatment. Two years before, he...

  • Nasilenie interpersonalnego poczucia winy w schizofrenii paranoidalnej. Britmann, Jonathan; Nasierowski, Tadeusz; Murawiec, Sławomir; Pawlus, Marzena; Fidler, Elżbieta // Psychiatria Polska;2012, Vol. 46 Issue 2, p157 

    Aim. The article presented results of a research designed to compare the feeling of guilt in healthy adults and in persons diagnosed with paranoid schizophrenia. Method. One hundred people diagnosed with paranoid schizophrenia participated in the research and 100 people without diagnosed...

  • Apparent motion perception in patients with paranoid schizophrenia. Sanders, Lia; de Millas, Walter; Heinz, Andreas; Kathmann, Norbert; Sterzer, Philipp // European Archives of Psychiatry & Clinical Neuroscience;Apr2013, Vol. 263 Issue 3, p233 

    Impaired perceptual inference has been suggested to be at the core of positive symptoms in schizophrenia. Apparent motion (AM) is a visual illusion in which perceptual inference gives rise to the experience of a single object moving back and forth when two spatially separated objects are flashed...

  • Clozapine.  // Reactions Weekly;10/20/2007, Issue 1174, p12 

    The article reports findings from a case study on the adverse effect of clozapine on a 55-year-old man diagnosed with paranoid schizophrenia. The man developed leucopenia associated with clozapine use and was hospitalized for controlled discontinuation of clozapine. The drug was stopped and the...

  • The Copenhagen High-Risk Project: The Diagnosis of Maternal Schizophrenia and its Relation to Offspring Diagnosis. Jørgensen, A.; Teasdale, T. W.; Parnas, J.; Schulsinger, F.; Schulsinger, H.; Mednick, S. A. // British Journal of Psychiatry;Dec87, Vol. 151, p573 

    The Copenhagen longitudinal high-risk study of offspring of 129 schizophrenic mothers commenced in 1962. At that time, the mothers were diagnosed according to contemporary Danish criteria. We have re-examined all of the hospital records of these mothers: 108 (84%) fulfil present-day DSM-III...

  • The sensory filter in schizophrenia: a study of habituation, arousal, and the dopamine hypothesis. Horvath, Thomas; Meares, Russell; Horvath, T; Meares, R // British Journal of Psychiatry;Jan79, Vol. 134, p39 

    The possible failure of a notional sensory filter in schizophrenia was studied by means of habituation of the orienting response. Non-paranoid schizophrenics failed to habituate, but paranoids habituated normally. Paranoids, however, showed a different impairment: they responded to a...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics