TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243]

Huf, Gisele; Coutinho, Evandro S. F.; Adams, Clive E.
January 2002
BMC Psychiatry;2002, Vol. 2, p11
Academic Journal
Background: Agitated or violent patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians and clinical practice all differ. Systematic reviews show that all relevant studies are small and none are likely to have adequate power to show true differences between treatments. Worldwide, current treatment is not based on evidence from randomised trials. In Brazil, the combination haloperidol-promethazine is frequently used, but no studies involving this mix exist. Methods: TREC-Rio (Tranquilização Rápida-Ensaio Clínico [Translation: Rapid Tranquillisation-Clinical Trial]) will compare midazolam with haloperidol-promethazine mix for treatment of agitated patients in emergency psychiatric rooms of Rio de Janeiro, Brazil. TREC-Rio is a randomised, controlled, pragmatic and open study. Primary measure of outcome is tranquillisation at 20 minutes but effects on other measures of morbidity will also be assessed. TREC-Rio will involve the collaboration of as many health care professionals based in four psychiatric emergency rooms of Rio as possible. Because the design of this trial does not substantially complicate clinical management, and in several aspects simplifies it, the study can be large, and treatments used in everyday practice can be evaluated.


Related Articles

  • An appraisal of the continuing practice of prescribing tranquillizing drugs for long-stay psychiatric patients. Hughes, J. S.; Little, J. Crawford; Little, J C // British Journal of Psychiatry;Aug67, Vol. 113 Issue 501, p867 

    The article presents the study that reviews the related literature concerning the withdrawal of phenothiazine drugs from long-stay hospitalized psychiatric patients in Great Britain. A survey was conducted regarding the conception and practice of using tranquilizing drugs for such patients in...

  • Relapse in Chronic Schizophrenics following Abrupt Withdrawal of Tranquillizing Medication. Prient, Robert F.; Cole, Jonathan O.; Belkin, Naomi F. // British Journal of Psychiatry;Jun69, Vol. 115 Issue 523, p679 

    The article examines the effects of withdrawing ataractic or tranquillizing medication from long stay schizophrenics at a number of hospitals. The study aimed to determine whether hospital setting is a significant variable affecting probability of relapse, and whether probability of relapse is...

  • Current practices in managing acutely disturbed patients at three hospitals in Rio de Janeiro-Brazil: a prevalence study. Huf, Gisele; Coutinho, Evandro da Silva Freire; Fagundes Jr., Hugo M.; Oliveira, Edmar S.; Lopez, Jose Ramon R. A.; Gewandszajder, Marcio; Carvalho, Andreia da Luz; Keusen, Alexandre; Adams, Clive E. // BMC Psychiatry;2002, Vol. 2, p4 

    Background: The medical management of aggressive and violent behaviour is a critical situation for which there is little evidence. In order to prepare for a randomised trial, due to start in the psychiatric emergency rooms of Rio de Janeiro in 2001, a survey of current practice was necessary....

  • Area security unit in a psychiatric hospital. Carney, M.W.P.; Nolan, P.A. // British Medical Journal;1/7/1978, Vol. 1 Issue 6104, p27 

    Since 1974 a psychiatric hospital security unit, designed to serve the whole catchment area, has cared for mentally ill (mostly psychotic) patients with disturbed behaviour that cannot be managed in open wards. There are a few long-term dangerous patients but most stay only briefly. The...

  • Psychiatric outcomes 10 years after treatment with antidepressants or anxiolytics. Colman, Ian; Croudace, Tim J.; Wadsworth, Michael E. J.; Kuh, Diana; Jones, Peter B. // British Journal of Psychiatry;Oct2008, Vol. 193 Issue 4, p327 

    Background: Antidepressants and anxiolytics have demonstrated short-term efficacy; however, little is known about the long-term effectiveness of these drugs.Aims: To investigate long-term psychiatric outcomes following antidepressant and/or anxiolytic use during an...

  • The epidemiological approach to psychotropic medication. Shepherd, Michael // Journal of the Royal Society of Medicine;Apr1982, Vol. 75 Issue 4, p226 

    The author reflects on the efficacy of psychotropic medication towards mental institutions in Europe. Base on the study among those hospitals that has utilized psychotropic drugs such as lithium carbonate for mental illness has brought only little or no improvement in the rate of discharges of...

  • Prevalencia de síndrome metabólico en un hospital psiquiátrico de México. Díaz-Castro, Lina; Cabello-Rangel, Héctor; J. Cuevas-Pineda, Guillermo; Reza-Garduño, Horacio; J. Castañeda-González, Carlos // Actas Espanolas de Psiquiatria;mar2011, Vol. 39 Issue 2, p115 

    Introduction. Metabolic syndrome (MS) consists of elevated blood pressure, hypercholesterolemia, hypertriglyceridemía, hyperglycemia and abdominal obesity. Mexico occupies the second place worldwide in prevalence of obesity. It has been reported that the use of psychopharmaceuticals increases...

  • A survey of prescribing of psychotropic drugs in a Birmingham psychiatric hospital. Edwards, Stephen; Kumar, Vinod; Edwards, S; Kumar, V // British Journal of Psychiatry;Jul84, Vol. 145, p502 

    Of 603 patients receiving in-patient or day-patient psychiatric care, one-sixth were taking no psychotropic drugs, but nearly 50% of those receiving medication had a combination of two or more such drugs. Hypnotics and minor tranquillisers were frequently prescribed together with neuroleptics...

  • The use of sulthiame with disturbed mentally subnormal patients. Moffatt, W. R.; Siddiqui, A. R.; MacKay, D. N. // British Journal of Psychiatry;Dec70, Vol. 117 Issue 541, p673 

    The article presents a study on the effects of sulthiame on 42 severely subnormal patients at a mental hospital in Northern Ireland. Such a trial is said to have been undertaken due to ineffectiveness of widely used tranquilizers such as phenothiazine derivatives. The epileptic patients were...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics